The avirulence of the cultivated Y strain of Trypanosoma cruzi: IV. The effect of immunosuppressive agents in mice

Drogas imunossupressoras (Azathioprina e Methotrexato) que se mostraram capazes de agravar infecções experimentais por Trypanosoma cruzi virulento (cepa Y), em camundongos, não conseguiram favorecer o aparecimento de qualquer sinal de infecção em animais vacinados com a cepa avirulenta PF do mesmo tripanosoma. Vinblastine, quando dado 3 dias antes da vacina, não favoreceu parasitemias positivas nem mortalidade significativamente aumentada, mas induziu o aparecimento de hemoculturas positivas. Os tripanosomas dessas culturas foram incapazes de infectar camundongos jovens. Quando o Vinblastine foi usado 15 dias após a vacinação dos animais, todos os testes foram negativos, inclusive as hemoculturas

Studies on Trypanosoma rangeli Tejera 1920. IV - A reconsideration of its systematic position

The systematic positon of Trypanosoma rangeli is reconsidered and the creation of a new subgenus. Tejeraia, is proposed to remove this trypanosome from the subgenus Herptosoma of the section Stercoraria. The characteristics described for the proposed subgenus indicate that it must be located in the section Salivaria rather than in the Stercoraria. The evidence supporting this proposition is discussed in the text.

Task force IV: Clinical use of ambulatory blood pressure monitoring. Participants of the 1999 Consensus Conference on Ambulatory Blood Pressure Monitoring

OBJECTIVE: To reach a consensus on the clinical use of ambulatory blood pressure monitoring (ABPM). METHODS: A task force on the clinical use of ABPM wrote this overview in preparation for the Seventh International Consensus Conference (23-25 September 1999, Leuven, Belgium). This article was amended to account for opinions aired at the conference and to reflect the common ground reached in the discussions. POINTS OF CONSENSUS: The Riva Rocci/Korotkoff technique, although it is prone to error, is easy and cheap to perform and remains worldwide the standard procedure for measuring blood pressure. ABPM should be performed only with properly validated devices as an accessory to conventional measurement of blood pressure. Ambulatory recording of blood pressure requires considerable investment in equipment and training and its use for screening purposes cannot be recommended. ABPM is most useful for identifying patients with white-coat hypertension (WCH), also known as isolated clinic hypertension, which is arbitrarily defined as a clinic blood pressure of more than 140 mmHg systolic or 90 mmHg diastolic in a patient with daytime ambulatory blood pressure below 135 mmHg systolic and 85 mmHg diastolic. Some experts consider a daytime blood pressure below 130 mmHg systolic and 80 mmHg diastolic optimal. Whether WCH predisposes subjects to sustained hypertension remains debated. However, outcome is better correlated to the ambulatory blood pressure than it is to the conventional blood pressure. Antihypertensive drugs lower the clinic blood pressure in patients with WCH but not the ambulatory blood pressure, and also do not improve prognosis. Nevertheless, WCH should not be left unattended. If no previous cardiovascular complications are present, treatment could be limited to follow-up and hygienic measures, which should also account for risk factors other than hypertension. ABPM is superior to conventional measurement of blood pressure not only for selecting patients for antihypertensive drug treatment but also for assessing the effects both of non-pharmacological and of pharmacological therapy. The ambulatory blood pressure should be reduced by treatment to below the thresholds applied for diagnosing sustained hypertension. ABPM makes the diagnosis and treatment of nocturnal hypertension possible and is especially indicated for patients with borderline hypertension, the elderly, pregnant women, patients with treatment-resistant hypertension and patients with symptoms suggestive of hypotension. In centres with sufficient financial resources, ABPM could become part of the routine assessment of patients with clinic hypertension. For patients with WCH, it should be repeated at annual or 6-monthly intervals. Variation of blood pressure throughout the day can be monitored only by ABPM, but several advantages of the latter technique can also be obtained by self-measurement of blood pressure, a less expensive method that is probably better suited to primary practice and use in developing countries. CONCLUSIONS: ABPM or equivalent methods for tracing the white-coat effect should become part of the routine diagnostic and therapeutic procedures applied to treated and untreated patients with elevated clinic blood pressures. Results of long-term outcome trials should better establish the advantage of further integrating ABPM as an accessory to conventional sphygmomanometry into the routine care of hypertensive patients and should provide more definite information on the long-term cost-effectiveness. Because such trials are not likely to be funded by the pharmaceutical industry, governments and health insurance companies should take responsibility in this regard.

A study of the labour market trajectories in the Grand Duchy of Luxembourg

We present an analysis of the register of all unemployment episodes in the Grand Duchy of Luxembourg over a recent period of 55 months. We apply propensity score matching to account forthe systematic differences among the groups of subjects (registrants) and unemployment spells.We devise graphical and tabular summaries for describing the sequences of employment states ofthe members of the labour force who register at Agence pour le d?veloppement de l'emploi, theLuxembourg Public Unemployment Agency. Some employment-related information about themis collected by linking their records to the national register of social security contributions, maintained by Inspection g?n?rale de la s?curit? sociale. A class of univariate indices for characterisingthe sequences of labour force states is defined.

Long-lasting antidiabetic effect of a dipeptidyl peptidase IV-resistant analog of glucagon-like peptide-1.

Glucagon-like peptide-1(7-37) (GLP-1) is the most potent insulinotropic hormone characterized thus far. Because its activity is preserved in non-insulin-dependent diabetes mellitus (NIDDM) patients, it is considered a potential new drug for the treatment of this disease. One limitation in its therapeutic use is a short half-life in vivo (5 minutes), due in part to a fast degradation by the endoprotease dipeptidylpeptidase IV (DPPIV). Recently, it was reported that GLP-1 became resistant to DPPIV when the alanine residue at position 8 was replaced by a glycine (GLP-1-Gly8). We report here that this change slightly decreased the affinity of the peptide for its receptor (IC50, 0.41 +/- 0.14 and 1.39 +/- 0.61 nmol/L for GLP-1 and GLP-1-Gly8, respectively) but did not change the efficiency to stimulate accumulation of intracellular cyclic adenosine monophosphate (cAMP) (EC50, 0.25 +/- 0.05 and 0.36 +/- 0.06 nmol/L for GLP-1 and GLP-1-Gly8, respectively). Second, we demonstrate for the first time that this mutant has an improved insulinotropic activity compared with the wild-type peptide when tested in vivo in an animal model of diabetes. A single injection of 0.1 nmol GLP-1-Gly8 in diabetic mice fed a high-fat diet can correct fasting hyperglycemia and glucose intolerance for several hours, whereas the activity of 1 nmol GLP-1 vanishes a few minutes after injection. These actions were correlated with increased insulin and decreased glucagon levels. Interestingly, normoglycemia was maintained over a period that was longer than the predicted peptide half-life, suggesting a yet undescribed long-term effect of GLP-1-Gly8. GLP-1-Gly8 thus has a markedly improved therapeutic potential compared with GLP-1, since it can be used at much lower doses and with a more flexible schedule of administration.

Fourth Report of the Iowa Library Commission Made to the Governor of Iowa, 1906-1908

1906-1908 Iowa Library Commission Report made to the Governor of Iowa.

Pasquale del Pezzo, Duke of Caianello, Neapolitan mathematician

This article is dedicated to a reconstruction of some events and achievements, both personal and scientific, in the life of the Neapolitan mathematician Pasquale del Pezzo, Duke of Caianello.

Dell'arcano del mare / Robert Dudley (junior) Earl of Warwick and Leicester, Duke of Northumberland

Sir Robert Dudleyn arvokas karttateos Dell´Arcano del Mare, osat I-III, on varhaisin koko maapallon kattava merikartasto. Se on myös ensimmäinen merikartasto, joka on laadittu Mercatorin projektion mukaan. Kartastoon on koottu yhteen kaikki silloinen tietämys merenkulusta. Se sisältää merenkulun ja navigoinnin teoriaa, laivanrakennusta ja astronomiaa käsittelevät tekstiosuudet, 145 merikarttaa sekä 180 kuvaliitettä, joiden tekijänä on tunnettu kaivertaja Antonio Francesco Lucini. Kaiverrukset, joiden tekemiseen Lucini oli käyttänyt 12 vuotta, ovat poikkeuksellisen hienolaatuisia, kuten teoksen muukin painotyö. Dudleyn kartasto kuuluu Kansalliskirjaston A. E. Nordenskiöldin karttojen ja kartografisen kirjallisuuden kokoelmaan, joka on liitetty ainoana suomalaisena kohteena Unescon Memory of the World –rekisteriin.

The dominions of the Czar of Russia Alba or Great Duke of Moscovia in which are the Dukedoms of Moscow, Wolodimer, Rezan, Worotin, Novogorod-Sewierski, Czernihow, Smolensko, Reschow, Twer, Novogorod-Weliki, Biele Jezora, Wologda, .. /

1 kartta :, käsinvär. ;, 57 x 88 cm, lehti 62,5 x 92,5 cm

Suomi "the Land of a Thousand Lakes": a short descriptive account of the Grand Duchy of Finland

Inneh. bl. a. en engelsk öfvers af Runebergs "Vårt land".