992 resultados para Failure Load


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Es cada vez más frecuente la rehabilitación de patrimonio construido, tanto de obras deterioradas como para la adecuación de obras existentes a nuevos usos o solicitaciones. Se ha considerado el estudio del refuerzo de obras de fábrica ya que constituyen un importante número dentro del patrimonio tanto de edificación como de obra civil (sistemas de muros de carga o en estructuras principales porticadas de acero u hormigón empleándose las fábricas como cerramiento o distribución con elementos autoportantes). A la hora de reparar o reforzar una estructura es importante realizar un análisis de las deficiencias, caracterización mecánica del elemento y solicitaciones presentes o posibles; en el apartado 1.3 del presente trabajo se refieren acciones de rehabilitación cuando lo que se precisa no es refuerzo estructural, así como las técnicas tradicionales más habituales para refuerzo de fábricas que suelen clasificarse según se trate de refuerzos exteriores o interiores. En los últimos años se ha adoptado el sistema de refuerzo de FRP, tecnología con origen en los refuerzos de hormigón tanto de elementos a flexión como de soportes. Estos refuerzos pueden ser de láminas adheridas a la fábrica soporte (SM), o de barras incluidas en rozas lineales (NSM). La elección de un sistema u otro depende de la necesidad de refuerzo y tipo de solicitación predominante, del acceso para colocación y de la exigencia de impacto visual. Una de las mayores limitaciones de los sistemas de refuerzo por FRP es que no suele movilizarse la resistencia del material de refuerzo, produciéndose previamente fallo en la interfase con el soporte con el consecuente despegue o deslaminación; dichos fallos pueden tener un origen local y propagarse a partir de una discontinuidad, por lo que es preciso un tratamiento cuidadoso de la superficie soporte, o bien como consecuencia de una insuficiente longitud de anclaje para la transferencia de los esfuerzos en la interfase. Se considera imprescindible una caracterización mecánica del elemento a reforzar. Es por ello que el trabajo presenta en el capítulo 2 métodos de cálculo de la fábrica soporte de distintas normativas y también una formulación alternativa que tiene en cuenta la fábrica histórica ya que su caracterización suele ser más complicada por la heterogeneidad y falta de clasificación de sus materiales, especialmente de los morteros. Una vez conocidos los parámetros resistentes de la fábrica soporte es posible diseñar el refuerzo; hasta la fecha existe escasa normativa de refuerzos de FRP para muros de fábrica, consistente en un protocolo propuesto por la ACI 440 7R-10 que carece de mejoras por tipo de anclaje y aporta valores muy conservadores de la eficacia del refuerzo. Como se ha indicado, la problemática principal de los refuerzos de FRP en muros es el modo de fallo que impide un aprovechamiento óptimo de las propiedades del material. Recientemente se están realizando estudios con distintos métodos de anclaje para estos refuerzos, con lo que se incremente la capacidad última y se mantenga el soporte ligado al refuerzo tras la rotura. Junto con sistemas de anclajes por prolongación del refuerzo (tanto para láminas como para barras) se han ensayado anclajes con llaves de cortante, barras embebidas, o anclajes mecánicos de acero o incluso de FRP. Este texto resume, en el capítulo 4, algunas de las campañas experimentales llevadas a cabo entre los años 2000 y 2013 con distintos anclajes. Se observan los parámetros fundamentales para medir la eficacia del anclajes como son: el modo de fallo, el incremento de resistencia, y los desplazamientos que permite observar la ductilidad del refuerzo; estos datos se analizan en función de la variación de: tipo de refuerzo incluyéndose el tipo de fibra y sistema de colocación, y tipo de anclaje. Existen también parámetros de diseño de los propios anclajes. En el caso de barras embebidas se resumen en diámetro y material de la barra, acabado superficial, dimensiones y forma de la roza, tipo de adhesivo. En el caso de anclajes de FRP tipo pasador la caracterización incluye: tipo de fibra, sistema de fabricación del anclajes y diámetro del mismo, radio de expansión del abanico, espaciamiento longitudinal de anclajes, número de filas de anclajes, número de láminas del refuerzo, longitud adherida tras el anclaje; es compleja la sistematización de resultados de los autores de las campañas expuestas ya que algunos de estos parámetros varían impidiendo la comparación. El capítulo 5 presenta los ensayos empleados para estas campañas de anclajes, distinguiéndose entre ensayos de modo I, tipo tracción directa o arrancamiento, que servirían para sistemas NSM o para cuantificar la resistencia individual de anclajes tipo pasador; ensayos de modo II, tipo corte simple, que se asemeja más a las condiciones de trabajo de los refuerzos. El presente texto se realiza con objeto de abrir una posible investigación sobre los anclajes tipo pasador, considerándose que junto con los sistemas de barra embebida son los que permiten una mayor versatilidad de diseño para los refuerzos de FRP y siendo su eficacia aún difícil de aislar por el número de parámetros de diseño. Rehabilitation of built heritage is becoming increasingly frequent, including repair of damaged works and conditioning for a new use or higher loads. In this work it has been considered the study of masonry wall reinforcement, as most buildings and civil works have load bearing walls or at least infilled masonry walls in concrete and steel structures. Before repairing or reinforcing an structure, it is important to analyse its deficiencies, its mechanical properties and both existing and potential loads; chapter 1, section 4 includes the most common rehabilitation methods when structural reinforcement is not needed, as well as traditional reinforcement techniques (internal and external reinforcement) In the last years the FRP reinforcement system has been adopted for masonry walls. FRP materials for reinforcement were initially used for concrete pillars and beams. FRP reinforcement includes two main techniques: surface mounted laminates (SM) and near surface mounted bars (NSM); one of them may be more accurate according to the need for reinforcement and main load, accessibility for installation and aesthetic requirements. One of the main constraints of FRP systems is not reaching maximum load for material due to premature debonding failure, which can be caused by surface irregularities so surface preparation is necessary. But debonding (or delamination for SM techniques) can also be a consequence of insufficient anchorage length or stress concentration. In order to provide an accurate mechanical characterisation of walls, chapter 2 summarises the calculation methods included in guidelines as well as alternative formulations for old masonry walls as historic wall properties are more complicated to obtain due to heterogeneity and data gaps (specially for mortars). The next step is designing reinforcement system; to date there are scarce regulations for walls reinforcement with FRP: ACI 440 7R-10 includes a protocol without considering the potential benefits provided by anchorage devices and with conservative values for reinforcement efficiency. As noted above, the main problem of FRP masonry walls reinforcement is failure mode. Recently, some authors have performed studies with different anchorage systems, finding that these systems are able to delay or prevent debonding . Studies include the following anchorage systems: Overlap, embedded bars, shear keys, shear restraint and fiber anchors. Chapter 4 briefly describes several experimental works between years 2000 and 2013, concerning different anchorage systems. The main parameters that measure the anchorage efficiency are: failure mode, failure load increase, displacements (in order to evaluate the ductility of the system); all these data points strongly depend on: reinforcement system, FRP fibers, anchorage system, and also on the specific anchorage parameters. Specific anchorage parameters are a function of the anchorage system used. The embedded bar system have design variables which can be identified as: bar diameter and material, surface finish, groove dimensions, and adhesive. In FRP anchorages (spikes) a complete design characterisation should include: type of fiber, manufacturing process, diameter, fan orientation, anchor splay width, anchor longitudinal spacing and number or rows, number or FRP sheet plies, bonded length beyond anchorage devices,...the parameters considered differ from some authors to others, so the comparison of results is quite complicated. Chapter 5 includes the most common tests used in experimental investigations on bond-behaviour and anchorage characterisation: direct shear tests (with variations single-shear and double-shear), pullout tests and bending tests. Each of them may be used according to the data needed. The purpose of this text is to promote further investigation of anchor spikes, accepting that both FRP anchors and embedded bars are the most versatile anchorage systems of FRP reinforcement and considering that to date its efficiency cannot be evaluated as there are too many design uncertainties.

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En el presente trabajo se estudia la sensibilidad a las entallas suaves de alambres de acero inoxidable dúplex fuertemente trefilado. Las entallas consideradas son reducciones de la sección transversal del alambre no simétricas respecto al eje de revolución. Tras constatar experimentalmente que los alambres con este tipo de daño fallan por agotamiento plástico, se ha determinado numéricamente la carga de agotamiento plástico en función de la profundidad de entalla empleando un mode-lo computacional de elementos finitos. Los resultados numéricos indican que la mayor deformabilidad del alambre debida a la entalla actúa en favor de su tolerancia al daño y permite que ésta alcance el límite superior dado por la carga de agotamiento a tracción simple del ligamento resistente.This research deals with the sensitivity to blunt notches of highly cold-drawn wires made of dúplex stainless steel. The analyzed notches are actually reductions of the wire cross section, asymmetrically mechanized with respect to the longitudinal wire axis. Once experimentally verified that the notched wires fail by plástic collapse, the failure load was found as a function of notch depth by means of a finite element model. The numerical results show that the higher compliance of the wires provided by the notch increases their damage tolerance up to the upper bound given by the tensile plástic failure load of the notch ligament.

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Entre los requisitos que deben cumplir las estructuras se debe garantizar que estas posean la durabilidad necesaria para permanecer en servicio a lo largo de todo el periodo de vida útil para el que han sido proyectadas. Para conseguir este objetivo las normativas han ido incorporando prescripciones para el diseño del hormigón, en base a distintas clases de exposición dependiendo del origen y magnitud de la agresividad exterior. En ambientes con una elevada agresividad, una de las comprobaciones que debe cumplir el hormigón es que tenga una permeabilidad inferior a los valores máximos fijados según la clase de exposición, y que en caso de considerar como ensayo de referencia el de penetración de agua, analiza el frente de penetración limitando las profundidades de penetración media y máxima. Adicionalmente a las condiciones de diseño según el tipo de ambiente, principalmente basadas en la dosificación del hormigón en términos de la relación agua/cemento y el mínimo contenido de cemento y el recubrimiento de las armaduras, durante la vida en servicio las estructuras pueden están solicitadas por distintas acciones imprevistas que pueden provocar cambios en la microestructura interna del hormigón que modifican su permeabilidad y resistencia, y por tanto pueden alterar la durabilidad inicialmente prevista. Es conocido el efecto de cansancio del hormigón cuando está solicitado por cargas de compresión mantenidas en el tiempo, provocando bajas en su resistencia debido al incremento de la microfisuración. Dada la relación entre la permeabilidad y la microfisuración del hormigón, es previsible el aumento de la permeabilidad en hormigones que han sido precomprimidos durante un periodo largo de tiempo. Los estudios de la permeabilidad en hormigones previamente comprimidos se han realizado analizando periodos de tiempo de compresión cortos que no permiten evaluar el efecto del cansancio sobre la permeabilidad. La presente tesis doctoral investiga la permeabilidad y resistencia a tracción en hormigones que previamente han sido comprimidos en carga mantenida durante distintos plazos de tiempo, al objeto de conocer su evolución en base al tiempo de precompresión. La investigación se apoya en el estudio de otras dos variables como son el tipo de hormigón de acuerdo a su dosificación según el tipo de ambiente considerando una agresividad baja, media o alta, y el grado de compresión aplicado respecto de su carga última de rotura. En los resultados del plan experimental desarrollado se ha obtenido que la permeabilidad presenta un incremento significante con el tiempo de precompresión, que dependiendo del valor inicial de la permeabilidad que tiene el hormigón puede provocar que hormigones que previamente satisfacen las limitaciones de permeabilidad pasen a incumplirlas, pudiendo afectar a su durabilidad. También se confirma la influencia del tiempo de precompresión sobre la resistencia a tracción obteniendo bajas de resistencia importantes en los casos pésimos ensayados, que deben ser tenidas en consideración en tanto afectan a la capacidad resistente del hormigón como a otros aspectos fundamentales como el anclaje de las armaduras en el hormigón armado y pretensado. One of the requirements that structures must meet is to guarantee their durability to remain in service throughout all the working life period for which they have been designed. To achieve this goal, building standards and codes have included specifications for the design of concrete structures, based on different exposure classes depending on the environmental conditions and their origin and magnitude. In severe aggressive environments, one of the specifications the concrete must meet is to have a permeability lower than the maximum values set for a certain exposure class. If this parameter is referenced to water penetration on specimens, then the average and maximum depths of front penetration are analyzed. In addition to the design conditions depending on the exposure class, which regulate the dosage of concrete in terms of the water/cement ratio, minimum samples that have been pre-compressed for a long period of time. Previous studies on permeability have been carried on pre-compressed concrete elements analyzing short periods of time. However, they have not studied the effects of compression forces on concrete in the long term. This Thesis investigates permeability and tensile strength of concrete samples that have been previously compressed under loads applied for different periods of time. The goal is to understand its evolution based on the time exposed to compression. The research variables also include the type of concrete according to the dosage used - depending on the environmental exposure it will have low, medium or high aggressiveness-, and the amount of compression applied in relation to its failure load. Results of the experimental tests showed that permeability increases significantly over the time of pre-compression. Depending on the initial value of permeability, this change could make the concrete not meet the original permeability restrictions and therefore affect its durability. These investigations also confirmed the influence of time of pre-compression in tensile strength, where some cases showed a significant decrease of resistance. These issues must be taken into consideration as they affect the bearing capacity of the material and other key features such as the anchoring of steel bars in reinforced and pre-stressed concrete. amount of cement content and the minimum concrete cover of the steel bars, during their working life structures may be subject to various unforeseen actions. As a result, the concrete’s internal microstructure might be affected, changing its permeability and resistance, and possibly altering the original specified durability. It is a known fact that when concrete is loaded in compression maintained over a long time, its resistance to compression forces is diminished due to the increase in micro-cracking. Considering the relationship between permeability and microcracking of concrete, an increase in permeability may be expected in concrete

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The purpose of this study was to examine the differences in knee extensor maximal and endurance strength in elderly. Sixteen healthy elderly served as subjects, eight of them trained , age 61.0±8.9 yrs; height, 170.6±6.8 cm; weight, 71.8±11.7 kg [mean ± standard deviation] and eight untrained 61.4±8.1 yrs, height 174.6±7.4 cm; weight 83.9 ±14.2 kg. Maximal strength in single leg extension exercise was measured unilaterally with the dominant leg until the subjects reached their 1 Repetition Maximum (RM) covering the full Range of Motion (ROM). Muscular endurance was obtained with a load of 75% of 1-RM for 3 consecutive sets, with 2 min rest periods till failure. Load at 1 RM was lower in absolute terms in untrained, but not significant, while the relative 1-RM test was significantly lower in untrained subjects (0.20 vs. 0.25 kg load/kg body weight) (p<0.05). The number of repetitions and amount of weight lifted performed of all 3 sets was higher in trained subjects, but not significant. In the trained group both repetitions and the load managed in the third set was significant lower compared with the first two sets. The result that maximal force output is more affected compared to muscular endurance in these subjects might be due to the habitual use of quadriceps femoris muscles during activity of daily living in both trained and untrained elderly.

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The black tern (Anous minutus) uses a semi-precocial growth strategy. Terrestrial locomotor capacity occurs soon after hatching, but pectoral limb development is delayed and flight is not possible until about post-hatching day 50. A growth series (hatchlings to fledglings) was used to explore how limb musculoskeletal development varied with body mass. In the pelvic limb, bone lengths scaled isometrically or with negative allometry. Gastrocnemius muscle mass and the failure load and stiffness of the tibiotarsus scaled isometrically. In the pectoral limb, pectoralis and supracoracoideus muscle masses increased with strong positive allometry that was mirrored by increases in wing bone strength and stiffness. Bending strength (σult) and modulus (E) remained fairly constant throughout development to fledging for all limb bones. The moment of inertia (I) scaled with negative allometry for the tibiotarsus and with strong positive allometry in the wing bones. Differences in σult and E of the tibiotarsus between pre-fledged chicks and adults was due, primarily, to increases in bone density rather than increases in the moment of inertia of the skeletal elements, whereas σult of wing bones was a function of increases in both bone density and I. Early development of functional pelvic limbs in tree-nesting birds is relatively unusual, and presumably reflects a familial trait that does not appear to compromise breeding success in this species.

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In this Thesis, details of a proposed method for the elastic-plastic failure load analysis of complete building structures are given. In order to handle the problem, a computer programme in Atlas Autocode is produced. The structures consist of a number of parallel shear walls and intermediate frames connected by floor slabs. The results of an experimental investigation are given to verify the theoretical results and to demonstrate various factors that may influence the behaviour of these structures. Large full scale practical structures are also analysed by the proposed method and suggestions are made for achieving design economy as well as for extending research in various aspects of this field. The existing programme for elastic-plastic analysis of large frames is modified to allow for the effect of composite action of structural members, i.e. reinforced concrete floor slabs and the supporting steel beams. This modified programme is used to analyse some framed type structures with composite action as well as those which incorporate plates and shear walls. The results obtained are studied to ascertain the influence of composite action and other factors on the load carrying capacity of both bare frames and complete building structures. The theoretical failure load presented in this thesis does not predict the overall failure load of the structure nor does it predict the partial failure load of the shear walls and slabs but it merely predicts the partial failure load of a single frame and assumes that the loss of stiffess of such a frame renders the overall structure unusable. For most structures the analysis proposed in this thesis is likely to break down prematurely due to the failure of the slab and shear wall system and this factor must be taken into account in any future work on such structures. The experimental work reported in this thesis is acknowledged to be unsatisfactory as a verification of the limited theory proposed. In particular perspex was not found to be a suitable material for testing at high loads, micro-concrete may be more suitable.

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This work is concerned with the behaviour of thin webbed rolled steel joists or universal beams when they are subjected to concentrated loads applied to the flanges. The prime concern is the effect of high direct stresses causing web failure in a small region of the beam. The review shows that although many tests have been carried out on rolled steel beams and built up girders, no series of tests has restricted the number of variables involved to enable firm conclusions to be drawn. The results of 100 tests on several different rolled steel universal beam sections having various types of loading conditions are presented. The majority of the beams are tested by loading with two opposite loads, thus eliminating the effects of bending and shear, except for a small number of beams which are tested simply supported on varying spans. The test results are first compared with the present design standard (BS 449) and it is shown that the British Standard is very conservative for most of the loading conditions included in the tests but is unsafe for others. Three possible failure modes are then considered, overall elastic buckling of the web, flexural yielding of the web due to large out of plane deflexions and local crushing of the material at the junction of the web and the root fillets. Each mode is considered theoretically and developed to establish the main variables, thus enabling a comparison to be made with the test results. It is shown that all three failure modes have a particular relevance for individual loading conditions, but that determining the failure load given the beam size and the loading conditions is very difficult in certain instances. Finally it is shown that there are some empirical relationships between the failure loads and the type of loading for various beam serial sizes.

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This thesis is concerned with the experimental and theoretical investigation into the compression bond of column longitudinal reinforcement in the transference of axial load from a reinforced concrete column to a base. Experimental work includes twelve tests with square twisted bars and twenty four tests with ribbed bars. The effects of bar size, anchorage length in the base, plan area of the base, provision of bae tensile reinforcement, links around the column bars in the base, plan area of column and concrete compressive strength were investigated in the tests. The tests indicated that the strength of the compression anchorage of deformed reinforcing steel in the concrete was primarily dependent on the concrete strength and the resistance to bursting, which may be available within the anchorage . It was shown in the tests without concreted columns that due to a large containment over the bars in the foundation, failure occurred due to the breakdown of bond followed by the slip of the column bars along the anchorage length. The experimental work showed that the bar size , the stress in the bar, the anchorage length, provision of the transverse steel and the concrete compressive strength significantly affect the bond stress at failure. The ultimate bond stress decreases as the anchorage length is increased, while the ultimate bond stress increases with increasing each of the remainder parameters. Tests with concreted columns also indicated that a section of the column contributed to the bond length in the foundation by acting as an extra anchorage length. The theoretical work is based on the Mindlin equation( 3), an analytical method used in conjunction with finite difference calculus. The theory is used to plot the distribution of bond stress in the elastic and the elastic-plastic stage of behaviour. The theory is also used to plot the load-vertical displacement relationship of the column bars in the anchorage length, and also to determine the theoretical failure load of foundation. The theoretical solutions are in good agreement with the experimental results and the distribution of bond stress is shown to be significantly influenced by the bar stiffness factor K. A comparison of the experimental results with the current codes shows that the bond stresses currently used are low and in particular, CPIlO(56) specifies very conservative design bond stresses .

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Objectives - Powdered and granulated particulate materials make up most of the ingredients of pharmaceuticals and are often at risk of undergoing unwanted agglomeration, or caking, during transport or storage. This is particularly acute when bulk powders are exposed to extreme swings in temperature and relative humidity, which is now common as drugs are produced and administered in increasingly hostile climates and are stored for longer periods of time prior to use. This study explores the possibility of using a uniaxial unconfined compression test to compare the strength of caked agglomerates exposed to different temperatures and relative humidities. This is part of a longer-term study to construct a protocol to predict the caking tendency of a new bulk material from individual particle properties. The main challenge is to develop techniques that provide repeatable results yet are presented simply enough to be useful to a wide range of industries. Methods - Powdered sucrose, a major pharmaceutical ingredient, was poured into a split die and exposed to high and low relative humidity cycles at room temperature. The typical ranges were 20–30% for the lower value and 70–80% for the higher value. The outer die casing was then removed and the resultant agglomerate was subjected to an unconfined compression test using a plunger fitted to a Zwick compression tester. The force against displacement was logged so that the dynamics of failure as well as the failure load of the sample could be recorded. The experimental matrix included varying the number of cycles, the amount between the maximum and minimum relative humidity, the height and diameters of the samples, the number of cycles and the particle size. Results - Trends showed that the tensile strength of the agglomerates increased with the number of cycles and also with the more extreme swings in relative humidity. This agrees with previous work on alternative methods of measuring the tensile strength of sugar agglomerates formed from humidity cycling (Leaper et al 2003). Conclusions - The results show that at the very least the uniaxial tester is a good comparative tester to examine the caking tendency of powdered materials, with a simple arrangement and operation that are compatible with the requirements of industry. However, further work is required to continue to optimize the height/ diameter ratio during tests.

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Aim: To investigate the effect of implant-abutment angulation and crown material on stress distribution of central incisors. Finite element method was used to simulate the clinical situation of a maxillary right central incisor restored by two different implant-abutment angulations, 15° and 25°, using two different crown materials (IPS E-Max CAD and zirconia). Methods: Two 3D finite element models were specially prepared for this research simulating the abutment angulations. Commercial engineering CAD/CAM package was used to model crown, implant abutment complex and bone (cortical and spongy) in 3D. Linear static analysis was performed by applying a 178 N oblique load. The obtained results were compared with former experimental results. Results: Implant Von Mises stress level was negligibly changed with increasing abutment angulation. The abutment with higher angulation is mechanically weaker and expected to fail at lower loading in comparison with the steeper one. Similarly, screw used with abutment angulation of 25° will fail at lower (about one-third) load value the failure load of similar screw used with abutment angulated by 15°. Conclusions: Bone (cortical and spongy) is insensitive to crown material. Increasing abutment angulation from 15° to 25°, increases stress on cortical bone by about 20% and reduces it by about 12% on spongy bone. Crown fracture resistance is dramatically reduced by increasing abutment angulation. Zirconia crown showed better performance than E-Max one.

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This paper presents two diagnostic methods for the online detection of broken bars in induction motors with squirrel-cage type rotors. The wavelet representation of a function is a new technique. Wavelet transform of a function is the improved version of Fourier transform. Fourier transform is a powerful tool for analyzing the components of a stationary signal. But it is failed for analyzing the non-stationary signal whereas wavelet transform allows the components of a non-stationary signal to be analyzed. In this paper, our main goal is to find out the advantages of wavelet transform compared to Fourier transform in rotor failure diagnosis of induction motors.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Objectives  To determine the improvement in positive predictive value of immunological failure criteria for identifying virological failure in HIV-infected children on antiretroviral therapy (ART) when a single targeted viral load measurement is performed in children identified as having immunological failure. Methods  Analysis of data from children (<16 years at ART initiation) at South African ART sites at which CD4 count/per cent and HIV-RNA monitoring are performed 6-monthly. Immunological failure was defined according to both WHO 2010 and United States Department of Health and Human Services (DHHS) 2008 criteria. Confirmed virological failure was defined as HIV-RNA >5000 copies/ml on two consecutive occasions <365 days apart in a child on ART for ≥18 months. Results  Among 2798 children on ART for ≥18 months [median (IQR) age 50 (21-84) months at ART initiation], the cumulative probability of confirmed virological failure by 42 months on ART was 6.3%. Using targeted viral load after meeting DHHS immunological failure criteria rather than DHHS immunological failure criteria alone increased positive predictive value from 28% to 82%. Targeted viral load improved the positive predictive value of WHO 2010 criteria for identifying confirmed virological failure from 49% to 82%. Conclusion  The addition of a single viral load measurement in children identified as failing immunologically will prevent most switches to second-line treatment in virologically suppressed children.