Estudo dos fatores de virulência e resistência à oxacilina em Staphylococcus spp. isolados de aspirado traqueal de pacientes em ventilação mecânica internados em UTI

Patients that are mechanically ventilated in ICUs are constantly exposed to different pathogens, which present multiantibiotic resistance. Among these microorganisms, is MRSA (Meticillin-Resistant Staphylococcus aureus) considered to be a therapeutic challenge due to its resistance to β-lactam antibiotics. Therefore, this study proposed to identify species of Staphylococcus spp. isolated from mechanically ventilated patients in ICU, the gene mecA detection and the genes of the enterotoxins A (sea), B (seb), C (sec-1) and D (sed) in samples of S. aureus, as well as the phenotypic resistance determination to oxacillin using the disc-diffusion method with discs of oxacillin and cefoxitin. The samples collection occurred during in a period of 19 months, obtaining samples from 232 patients. A percentage of 39% (70) of Gram-positive cocci were found; which 82,8% (58) were identified as Staphylococcus spp,. among these, 75,8% (44) corresponded to S. aureus species and 47,7% were identified as MRSA. It was found resistance to both drugs in 31,8% of the S. aureus samples, 16 (36,3%) had the gene sea and 11 (25%) had the sec-1 gene. Among the coagulase-negative staphylococci obtained, the species most found was S. epidermidis, corresponding to 43% (6). The results revealed that one of the most important etiologic agents of VAP amid the Gram-positive cocci is the species S. aureus, with special attention to MRSA. The presence of enterotoxins genes in S. aureus did not showed determinant role in VAP, but the presence of these superantigens can contribute worsening the patient’s prognosis, since they are associated with intense inflammatory response

José Feliciano de Castilho e a tradição clássica do séc. XIX: memória sobre a segunda égloga de Virgílio

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

O setor de venture capital, as startups e o empreendedorismo em Israel, nos anos recentes

Some of the factors that help to explain the Israeli success case on promoting high-tech start-ups backed by venture capital funds can be found in the risk-taking culture of the country, the vast technological know-how associated with the huge military development, the high offer of human intellectual capital due to the immigration processes, and finally also the FDI inflows, mainly from the United States. Even though, these factors would not have the same effects in the economy unless the right structures were founded by the public-private sectors partnerships for the high-tech industry development and the adaptation of the investment industry surpasses two of the deepest global financial crisis: the dot-com bubble in the 2000’s and the subprime in 2008

O FMI e o Sistema Financeiro Internacional: uma análise das mudanças estratégicas nas décadas de 1980 e 1990

The current study has aimed to analyze changes in strategies at the International Monetary Fund that occurred during the 1980s and 1990s. The analysis is done through the the recovery of the 1980s international economic scene, amid the global recession and debt crisis, and shows how the course of the decade and influenced changes under recommendations provided by the IMF to countries with balance of payments crisis. Furthermore, the paper also describes the changes in the international financial system, in some countries which have adopted them and also to the International Monetary Fund itself

Effects of lithium on the proliferation and migration of neuroblasts in the rostral migratory stream in adult mice

The discovery of neurogenesis in adult brains opened the possibility of cellular therapy strategies for the treatment of neurodegenerative diseases, such as Alzheimer’s disease. Neurogenesis in the adult brain occurs in two areas: subgranular zone of the hippocampus and subventricular zone (SVZ) of the lateral ventricles. Neurons that originate from the SVZ migrate to the olfactory bulb (OB) through the rostral migratory stream (RMS). In Alzheimer’s disease, there is a progressive neuronal dysfunction and degeneration, resulting in brain atrophy and cognitive impairments including olfactory dysfunction. Several studies have demonstrated that pharmacological treatment with lithium exerts positive effects on adult neurogenesis, and one pathway seems to be the modulation of factors that regulate the migration of neuroblasts. The objective of this study was to investigate whether treatment with lithium promotes the increase of migratory neuroblasts using as parameter the RMS. Adult male C57BL/6 mice were divided into control and lithium-treated groups. The animals were treated for 6 weeks and, at four different time points, i.e., 10 days, 7 days, 3 days and 1 day before the end of treatments, they received an injection of BrdU (cell proliferation marker). The animals were sacrificed by perfusion fixation and the brains were immunohistochemically labeled for BrdU for analysis of migrating neuroblasts in the RMS. The results showed that the number of BrdU+ cells in the RMS was not significantly different between the two groups, suggesting that lithium, alone, is not capable of increasing the number of neuroblasts migrating from the SVZ to the OB

Métodos econométricos para a análise do índice de inflação no Brasil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Gestão do ouro azul no contexto globalizado Neoliberal: bem econômico ou bem social?

The neoliberalism based on the Washington Consensus advised privatization as the most effective alternative for the management of natural resources. The question is what is prioritizing efficiency, market or welfare? The growing concern about the water issue has been highlighted in discussions in international policy debates, and what it turns out is the prominence of corporate and economic interests over social and environmental. The water is in crisis, there are several sources of popular conflicts around the world contrary to how this resource is being offered, as the Water War occurred in 2000 in the city of Cochabamba. It is necessary to respect its limitations to ensure their future availability and choose the best development model that favors the effectiveness of their control. The international proliferation of commercial vision concerning water stipulated privatization of their management as ideal rule, which increased rates, concentrated income, has not improved the quality nor promoted the conquest of equal access to water for most systems that provides these services, this is, privatization has not brought positive results that outweigh the harm of its implementation. Water is an essential commodity for life of living beings, in all its stages, basic reason to develop plans, rules and commitments that ensure its conservation and provide, as soon as possible, a valid alternative for the sustainable management in long term

O discurso sobre a concisão na Revista Língua Portuguesa

The objective was to seek positive and negative values that guide the discourse on conciseness and understand how this concept is understood in speeches in the media when taking the theme of text production. The corpus of work consists of two materials of Portuguese Language Magazine on this topic. The analysis of the corpus was made from Bakhtinian discourse studies, especially considering the concepts of dialogue, utterance and speech genres. The research considers mainly as Bakhtin Circle conceives the production of meaning. At the end, we believe it is important to reflect on the definitions that guide the discourse of conciseness, far in practice they are consistent with our reality of writing

Avaliação dos aspectos da dieta alimentar de Pimelodus maculatus em dois importantes tributários do reservatório de Jurumirim, Alto Rio Paranapanema-SP

The species Pimelodus maculatus is one of the most abundant fish in many artificial reservoirs. Shows feeding plasticity and exploits all trophic levels in aquatic ecosystems. This study aimed to analyze and compare aspects of the diet of P. maculatus in two important tributaries (Taquari and Veados rivers) in the upper Paranapanema River system, and also investigate possible differences in the condition factor using its feeding habit as reference. Samplings were carried out every three months during 2011 and 2012 in two tributaries of Jurumirim's dam. After biometric analysis, fish were dissected to remove the stomachs that were fixed in formaldehyde 10% and conserved in alcohol 70%. The stomach content was analyzed under stereomicroscope and the food items were identified until the least possible taxonomic level. The diet was characterized based on the Alimentary Index (IAi). Feeding strategy and aspects of species autoecology were evaluated by the relation between abundance of prey-specific (Pi) and occurrence frequency (Fo) of the prey, and also was calculated the niche width of Levin (B). The condition factor was also established and values obtained in samples of both rivers were compared, correlating them with diet of the species

A crise financeira de 2008: uma reflexão a partir da teoria da fragilidade financeira de Hyman Minsky

This paper aims to use the theoretical framework developed by Hyman P. Minsky for understanding the concept of financial fragility observed in the capitalist system. It is intended to clarify the concept of intrinsic instability to which capitalism is subject, which is responsible for generating more economic cycles - periods of prosperity and crashes that affect global economies - particularly the one initiated in the United States in 2008. Thus, we made theoretical analysis of the theory of economic cycles and financial instability beyond historical reviews on the biggest financial crisis since the Great Depression

Avaliação da Taxa de Exposição em Exames Radiológicos Realizados em Procedimentos Cirúrgicos - Minimização dos Riscos em Indivíduos Ocupacionalmente Expostos

This paper consists in the evaluation of the exposure rate to ionizing radiation to which professionals working in surgical procedures which require radiological examinations are subjected. Were initially performed real-time readings of exposure rate within four distinct operating rooms during the execution of four surgical procedures that made use of fluoroscopy equipment (including three orthopedic surgeries, one in the shoulder, one in the arm, another for deployment of metal pin in the leg region, and a fourth for vascular procedure); in these surgeries were used ionization chamber detector and an electrometer. In order to check the values achieved, was made a re-evaluation of the distribution of the rate of exposure to radiation, from the surgical procedures, now with thermoluminescent dosimeters (TLDs). For this, thirty TLDs were distributed in the operating rooms, arranged in points of interest as occupation by professionals. The TLDs were prepared for thirty consecutive days, after which they were removed and replaced with new dosimeters not exposed yet. The dosimeters were subjected to reading of the rate of exposure; this procedure was repeated for four months without interruption. The quantification of the results sought primarily to convert the rate of exposure for equivalent dose rate, both in measurements with ionization chamber as in measurements with TLDs, in order to highlight the presence of the biological effect of ionizing radiation for comparisons within scientific context. Then, the results were plotted to establish the relationship between the values of equivalent dose and the distance to the central axis of the x -ray source, confirming the inverse square law for distance. Finally, the values were associated with the maximum limit recommended by the legislation for occupationally exposed individuals. The methodology for the analysis and quantification of the data in this work aims at implementing a work plan that meets ...

As representações de Medeia nas Metamorfoses de Ovídio e na Argonáutica de Apolônio de Rodes

This paper focuses on how the ancient roman poet Ovid’s approach on the mythical character Medea in Metamorphoses Book VII relates to the presence of the character in the Hellenistic greek epic poem Argonautica of Apollonius Rhodius, once the Greek author is known to influence the Roman. Although Ovid’s narrative goes further and focuses on events subsequent to the Argonauts travel, the relationship between the two works allows to address two aspects: the inner monologue and the anxieties of Medea which, by their turn, draw a timeline of the historical influence of Euripedes’ tragedy Medea; going through Apollonius and eventually arriving at Ovid; and the description of Medea’s magical practices and powers, used in Argonautica to protect Jason, which are widely described in Metamorphoses when she rejuvenates Aeson, the hero’s father. It is intended not only to point out aspects of character related to these topics, but primarily to address the mechanisms that can identify the direct influence of Apollonius on Ovid

Escoamento da produção de café: uma projeção de logística

This paper seeks to show which impacts there are of the combined use of different modal for the coffee’s outflow. Nowadays is used, almost exclusively, the roadway to transport. How-ever, for this product with low added value, the types of transports best suited, in the litera-ture, are the railway and waterway. For this, is describe the development and spread of coffee throughout Brazil. Subsequently, is calculate the current cost of transporting two producing regions (Minas Gerais and Rondônia), using for that information about the freight, the social cost, and the level of losses along the way. After that is projected costs if utilizes the multi-modal model, when considering the same cost parameters used for the current model. Here-after, an analysis is made of the obtained cost, speed, consistency, capacity, availability and frequency of each transport model. Therefore, note that the multi-modal system is more ef-ficient and economical than current, based on transport by road

Determinantes e indicadores de eco-inovação

This study aimed to gather the determinants and indicators of environmental innovations through a literature review on the topic. But before it was made a presentation of concepts and typology of eco-innovation, with different points of view. The determinant more found by most authors was regulation, followed by market factors, cost reductions and company image. To highlight these determinants were presented some cases studies, including evidence in Brazil. Due to the short bibliography and case studies, there are few indicators of environmental innovation found, highlighting the investment in environmental R&D and patents

Distribuição espacial dos ninhos de Athene cunicularia (coruja-buraqueira) e dinâmica de sua utilização

A coruja-buraqueira (Athene cunicularia) nidififica no chão e, com frequência, ocorre em ambientes bastante urbanizados como no campus universitário da UNESP em Botucatu, SP região centro-oeste paulista. Os objetivos do estudo foram descrever as características físicas das escavações, distribuição espacial, formas de utilização e avaliar que elementos presentes nas áreas urbanas são importantes para a seleção dos sítios de nidificação. Foram monitorados 6 grupos familiares desde 2011, cuja população e o número de ninhos foram contabilizados e a localização, georeferenciados. Os dados comportamentais foram registrados em caderno de campo, fotografados e filmados. A densidade populacional no câmpus foi de 0,03 indivíduos por Km² com os sítios de nidificação vizinhos tendo a distância mínima de 140,0 metros e máxima de 378 metros. As tocas apresentaram 50,6± 5,6cm de diâmetro, a maioria construída em terreno com declive. As corujas selecionaram sítios de nidificação em áreas abertas e gramadas contendo no entorno poleiros naturais (árvores, arvoretas, arbustos) e artificiais (placas, postes, peitoral de janelas, etc) e próximos a bueiros e postes com iluminação artificial. Estes dois últimos constituíram atrativos paras as suas presas (artrópodes e roedores) e a análise de ergagrópilas revelou a ocorrência de 5 grupos taxonômicos de artrópodes: 65,4% de Coleóptera, 27,2% de Orthoptera, 4,6% de Blatodea, 1,4% de Aranae, 0,9% de Hymenoptra e 0,4% de Mantodea. Os resultados obtidos mostraram que as corujas-buraqueiras levaram em consideração características como oferta abundante de alimento, principalmente, de artrópodes que se concentravam nas área iluminadas e nos bueiros. A estabilidade temporal dos sítios de nidificação nestes três anos de monitoramento acompanhada de sucesso reprodutivo de 50% revela que a despeito do intenso tráfego de veículos e transeuntes no campus, o ambiente ...