The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms.

Salmonella typhimurium can colonize the gut, invade intestinal tissues, and cause enterocolitis. In vitro studies suggest different mechanisms leading to mucosal inflammation, including 1) direct modulation of proinflammatory signaling by bacterial type III effector proteins and 2) disruption or penetration of the intestinal epithelium so that penetrating bacteria or bacterial products can trigger innate immunity (i.e., TLR signaling). We studied these mechanisms in vivo using streptomycin-pretreated wild-type and knockout mice including MyD88(-/-) animals lacking an adaptor molecule required for signaling via most TLRs. The Salmonella SPI-1 and the SPI-2 type III secretion systems (TTSS) contributed to inflammation. Mutants that retain only a functional SPI-1 (M556; sseD::aphT) or a SPI-2 TTSS (SB161; DeltainvG) caused attenuated colitis, which reflected distinct aspects of the colitis caused by wild-type S. typhimurium: M556 caused diffuse cecal inflammation that did not require MyD88 signaling. In contrast, SB161 induced focal mucosal inflammation requiring MyD88. M556 but not SB161 was found in intestinal epithelial cells. In the lamina propria, M556 and SB161 appeared to reside in different leukocyte cell populations as indicated by differential CD11c staining. Only the SPI-2-dependent inflammatory pathway required aroA-dependent intracellular growth. Thus, S. typhimurium can use two independent mechanisms to elicit colitis in vivo: SPI-1-dependent and MyD88-independent signaling to epithelial cells and SPI-2-dependent intracellular proliferation in the lamina propria triggering MyD88-dependent innate immune responses.

Delivery of the p67 sporozoite antigen of Theileria parva by using recombinant Salmonella dublin: secretion of the product enhances specific antibody responses in cattle

The p67 sporozoite antigen of Theileria parva has been fused to the C-terminal secretion signal of Escherichia coli hemolysin and expressed in secreted form by attenuated Salmonella dublin aroA strain SL5631. The recombinant p67 antigen was detected in the supernatant of transformed bacterial cultures. Immunization trials in cattle revealed that SL5631 secreting the antigen provoked a 10-fold-higher antibody response to p67 than recombinant SL5631 expressing but not secreting p67. Immunized calves were challenged with a 80% lethal dose of T. parva sporozoites and monitored for the development of infection. Two of three calves immunized intramuscularly with the p67-secreting SL5631 strain were found to be protected, whereas only one of three animals immunized with the nonsecreting p67-expressing SL5631 strain was protected. This is the first demonstration that complete eukaryotic antigens fused to the C-terminal portion of E. coli hemolysin can be exported from attenuated Salmonella strains and that such exported antigens can protect cattle against subsequent parasite challenge.

Jesus-en Compañiaco A. Sebastian Mendiburuc euscaraz eracusten duen Jesus-en Bihotza-ren devocioa.

Sign.: [calderón]8, A-Z8, 2A-2B8

Aita San Ignacioren egercicioen gañean afectoac : beren egemplo ta dotriñaquin edo Egercicioen IIen partean / Jaincoarren ministro celosoai Jesusen Compañiaco aita Agustin Cardaberaz esquentcen ta dedicatcen diena.

Sign.: A-Z8, 2A-2B8, 2C4

Jaungoicuaren Amar Aguindubeetaco azqueneco bosteen icasiquizunac. II. zatija / Bartolome Santa Teresac predicadoriac aterac.

Dialecto : texto en euskera occidental -- vizcaíno, variedad oriental

Confesioco eta comunioco sacramentuen gañean eracusaldiac : lenbicico Comunioraco prestatu bear diran aurrentzat eta bidez Cristau acientzat-ere bai / esqueintzen diezte euscaldunai Juan Bautista Aguirre, Asteasuco Beneficiadu, eta Guipuzcoaco Arciprestazco nagusian Diputadu Generalac.

Dialecto : texto en euskera central -- guipuzcoano

Ceruraco bide zucena eta segurua / Antonio María Claret Trajanopolisco Arzobispo Jaunac gaztelaniaz ipiñi zuenetic Manuel Antonio Antia Urnietaco Erretoreac euscarara itzulia.

Dialecto : texto en euskera central -- guipuzcoano

Manual de higiene y medicina popular : dedicado a los habitantes del país vascongado = [Errico gendeentzat osasun legueac eta medicantzaco arguibideac : euskal-erritarrai esqueñiac / con un prólogo de Carmelo de Echegaray ; y escrito en castellano y vascuence por los médicos titulares de Deva é Iciar Martín Arámburu y Manuel Bago Aguirre / erderaz eta euskeraz Devaco eta Itziarco medicu Martin Aramburu eta Manuel Bago Aguirrec ipiñiac].

Dialecto : texto en euskera central -- guipuzcoano

Umiaren lenengo aizkidia : Bizkaiko euzkeraz irakurrtzen ikasteko / bizkattarr batek iratzija.

Datos del autor tomados del Jon Bilbao

Guizadiaren eta batez ere ichaz-guizonen izar eder eta laguntza benetakoa dan Ama Virjiña Iziar-coaren condaraichoa : bere bederatziurren eta canta batzuequin / [Pedro José Aldazabal-ec eskribitu] ; Vicente Aizpuruc laburtu eta zucendu ; eta Francisco Maria Gorosteguic euskarara itzulia.

El nombre del autor está sacado del texto

Grammaire bilingue : française et basque / par J.-B. Archu = Bi mihiren gramatika : uskara eta Franzesa / egina J.-B. Archu.

Texto paralelo en francés y euskera

Diccionario basco-español titulado euskeratik erderara biurtzeco itztegia / su autor J. Francisco de Aizquibel.

En el primer tomo no aparece la fecha de publicación

Gramática de los cuatro dialectos literarios de la lengua euskara / por Arturo Campión.

Dialecto : textos en euskera occidental -- vizcaíno, central -- guipuzcoano, labortano y suletino

Lora-sorta espirituala ta propositu santuak bizitza barri bat egiteko / Aita Palacios misionariak misio-ondoan emoten zituanak ; Pedro Antonio Añibarrok bizkaiko euskeran ifini ditu.

Dialecto : texto en euskera occidental -- vizcaíno, variedad occidental-arratia

Diccionario basco-español titulado euskeratik erderara biurtzeko itztegia / su autor J. Francisco de Aizkibel.

Litografía en color de A. Morales de los Ríos e impresa en Barcelona por Vda e Hijos de Labielle