Supporting the development of inclusive products : the effects of everyday ambient illumination levels and contrast on older adults' near visual acuity

Current older adult capability data-sets fail to account for the effects of everyday environmental conditions on capability. This article details a study that investigates the effects of everyday ambient illumination conditions (overcast, 6000 lx; in-house lighting, 150 lx and street lighting, 7.5 lx) and contrast (90%, 70%, 50% and 30%) on the near visual acuity (VA) of older adults (n= 38, 65-87 years). VA was measured at a 1-m viewing distance using logarithm of minimum angle of resolution (LogMAR) acuity charts. Results from the study showed that for all contrast levels tested, VA decreased by 0.2 log units between the overcast and street lighting conditions. On average, in overcast conditions, participants could detect detail around 1.6 times smaller on the LogMAR charts compared with street lighting. VA also significantly decreased when contrast was reduced from 70% to 50%, and from 50% to 30% in each of the ambient illumination conditions. Practitioner summary: This article presents an experimental study that investigates the impact of everyday ambient illumination levels and contrast on older adults' VA. Results show that both factors have a significant effect on their VA. Findings suggest that environmental conditions need to be accounted for in older adult capability data-sets/designs.

Probing second harmonic components of pH-sensitive Redox processes in a mesoporous TiO2-Nafion film electrode with Fourier-transformed large-amplitude sinusoidally modulated voltammetry

Electrochemical processes in mesoporous TiO2-Nafion thin films deposited on indium tin oxide (ITO) electrodes are inherently complex and affected by capacitance, Ohmic iR-drop, RC-time constant phenomena, and by potential and pH-dependent conductivity. In this study, large-amplitude sinusoidally modulated voltammetry (LASMV) is employed to provide access to almost purely Faradaic-based current data from second harmonic components, as well as capacitance and potential domain information from the fundamental harmonic for mesoporous TiO2-Nafion film electrodes. The LASMV response has been investigated with and without an immobilized one-electron redox system, ferrocenylmethyltrimethylammonium+. Results clearly demonstrate that the electron transfer associated with the immobilized ferrocene derivative follows two independent pathways i) electron hopping within the Nafion network and ii) conduction through the TiO2 backbone. The pH effect on the voltammetric response for the TiO2 reduction pathway (ii) can be clearly identified in the 2nd harmonic LASMV response with the diffusion controlled ferrocene response (i) acting as a pH independent reference. Application of second harmonic data derived from LASMV measurement, because of the minimal contribution from capacitance currents, may lead to reference-free pH sensing with systems like that found for ferrocene derivatives.

Common genetic variants influence human subcortical brain structures

The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270; P = 1.08×10 -33; 0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability in human brain development, and may help to determine mechanisms of neuropsychiatric dysfunction.

Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group

The pattern of structural brain alterations associated with major depressive disorder (MDD) remains unresolved. This is in part due to small sample sizes of neuroimaging studies resulting in limited statistical power, disease heterogeneity and the complex interactions between clinical characteristics and brain morphology. To address this, we meta-analyzed three-dimensional brain magnetic resonance imaging data from 1728 MDD patients and 7199 controls from 15 research samples worldwide, to identify subcortical brain volumes that robustly discriminate MDD patients from healthy controls. Relative to controls, patients had significantly lower hippocampal volumes (Cohen’s d=−0.14, % difference=−1.24). This effect was driven by patients with recurrent MDD (Cohen’s d=−0.17, % difference=−1.44), and we detected no differences between first episode patients and controls. Age of onset ⩽21 was associated with a smaller hippocampus (Cohen’s d=−0.20, % difference=−1.85) and a trend toward smaller amygdala (Cohen’s d=−0.11, % difference=−1.23) and larger lateral ventricles (Cohen’s d=0.12, % difference=5.11). Symptom severity at study inclusion was not associated with any regional brain volumes. Sample characteristics such as mean age, proportion of antidepressant users and proportion of remitted patients, and methodological characteristics did not significantly moderate alterations in brain volumes in MDD. Samples with a higher proportion of antipsychotic medication users showed larger caudate volumes in MDD patients compared with controls. This currently largest worldwide effort to identify subcortical brain alterations showed robust smaller hippocampal volumes in MDD patients, moderated by age of onset and first episode versus recurrent episode status.

The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

Novel ANKH amino terminus mutation (Pro5Ser) associated with early-onset calcium pyrophosphate disease with associated phosphaturia

This report describes a 32-year-old woman presenting since childhood with progressive calcium pyrophosphate disease (CPPD), characterized by severe arthropathy and chondrocalcinosis involving multiple peripheral joints and intervertebral disks. Because ANKH mutations have been previously described in familial CPPD, the proband's DNA was assessed at this locus by direct sequencing of promoter and coding regions and revealed 3 sequence variants in ANKH. Sequences of exon 1 revealed a novel isolated nonsynonymous mutation (c.13 C>T), altering amino acid in codon 5 from proline to serine (CCG>TCG). Sequencing of parental DNA revealed an identical mutation in the proband's father but not the mother. Subsequent clinical evaluation demonstrated extensive chondrocalcinosis and degenerative arthropathy in the proband's father. In summary, we report a novel mutation, not previously described, in ANKH exon 1, wherein serine replaces proline, in a case of early-onset severe CPPD associated with metabolic abnormalities, with similar findings in the proband's father.

Tumour islet Foxp3+ T-cell infiltration predicts poor outcome in nonsmall cell lung cancer

The impact of host immunity on outcome in nonsmall cell lung cancer (NSCLC) is controversial. We examined the relationship between lymphoid infiltration patterns in NSCLC and prognosis. Tumour- and stroma-infiltrating CD3+, CD8+ and forkhead box P3 (Foxp3)+ T-lymphocytes were identified using immunohistochemistry and a novel image analysis algorithm to assess total, cytotoxic and regulatory T-lymphocyte counts, respectively, in 196 NSCLC cases. The median cell count was selected as a cut-point to define patient subgroups and the ratio of the corresponding tumour islet:stroma (TI/S) counts was determined. There was a positive association between overall survival and increased CD8+ TI/S ratio (hazard ratio (HR) for death 0.44, p<0.001) but an inverse relationship between Foxp3+ TI/S ratio and overall survival (HR 4.86, p<0.001). Patients with high CD8+ islet (HR 0.48, p<0.001) and Foxp3+ stromal (HR 0.23, p<0.001) counts had better survival, whereas high CD3+ and CD8+ stromal counts and high Foxp3+ islet infiltration conferred a worse survival (HR 1.55, 2.19 and 3.14, respectively). By multivariate analysis, a high CD8+ TI/S ratio conferred an improved survival (HR 0.48, p=0.002) but a high Foxp3+ TI/S ratio was associated with worse survival (HR 3.91, p<0.001). Microlocalisation of infiltrating T-lymphocytes is a powerful predictor of outcome in resected NSCLC.

Sosiaalisen median odotuksia ja käyttötarpeita osana asiantuntijaorganisaation viestintää

Tarkastelen pro gradu -tutkielmassani työyhteisön viestintätapojen muutosta ja sosiaalisen mediai roolia muutoksessa. Tutkimukseni tavoitteena on jäsentää ja ymmärtää sosiaalisen median roolia työyhteisön viestinnässä ja tarkastella miten sosiaalinen media taipuu tietoperustaisen asiantuntiorganisaation tarpeisiin. Tutkimuksen teoreettisessa osuudessa selvitän sitä, miten työn tekemisessä tapahtuneet muutokset ovat muuttaneet työyhteisön tapaa ja tarvetta viestiä. Työn tekemisen uusia muotoja ja verkostoitumista jäsennän tutkimuskirjallisuuden Alvesson (2000), Gruber & Palonen (2007), Kasvio & Tjäder (2007), Sennett (2007) kautta. Työn uusia muotoja voidaan kuvata käsitteillä asiantuntijakeskeisyys, tietointensiivisyys ja tietoperustainen työ. Kuva tutkimuksessani myös sosiaalisen median käsitettä sekä sen tunnusomaisuuksia. Tarkastelen tietoperustaisen asiantuntijaorganisaation odotuksia ja käyttötarpeita sosiaaliselle medialle Elisa Juholinin (2008) määrittelemän työyhteisöviestinnän uuden agendan (agendamalli) viitekehykses Tutkimukseni empiirisessä osuudessa tarkastelen aihetta yhden tietoperustaisen asiantuntijaorganisaation jäsenten kautta. Tavoitteeni on selvittää 1) millaisia odotuksia asiantuntijaorganisaatiossa työskentelevillä on sosiaalisen median käytöstä osana työyhteisön viestintää sekä 2) millaisia käyttötarpeita asiantuntijaorganisaatiossa työskentelevillä on sosiaalis* median käytöstä osana työyhteisön viestintää. Tutkimusotteeni on laadullinen, ja aineiston keruur menetelmänä käytän fokusryhmäkeskustelua sekä teemahaastattelua. Analysoin aineiston teemoittelemalla. Aineiston koodauksessa käytin Atlas.ti -ohjelmaa. Tutkimukseni perusteella voidaan todeta, että tärkeimpänä sosiaalisen median odotuksiin ja käyttötarpeisiin liittyi ajatus käyttäjälähtöisyydestä ja vuorovaikutuksesta. Käyttäjälähtöisyys ja vuorovaikutus näkyivät erityisesti odotuksena viestinnän rutiinien, tiedon ja osaamisen jakamisena entistä avoimempaan ; vuorovaikutteisempaan suuntaan. Tutkimus antaa viitteitä siitä, että sosiaalisen median sovelluksilla on mahdollista tukea vuorovaikutusta juuri niissä työyhteisöviestinnän tehtävissä, joissa vuorovaikutus jää helposti vähäiseksi. Sosiaalisen median sovelluksia tarvitaan myös tietoperustaisen asiantuntijaorganisaation osaamisen ja ns. hiljaisen tiedonjakamiseen. Tutkimuksen perusteella sosiaalinen media osana työyhteisön viestintää taipuu tiedontarpeen tyydyttäjänä, tarjoaa vaihtoehdon viestintäkanaville ja viestinnän toimintamalleille, mahdollistaa osallistumaan ja vaikuttamaan työyhteisön asioihin sekä tarjoaa tavan koota työyhteisössä olevaa osaamista ja hiljaista tietoa.

Examining the effects of species richness on community stability: an assembly model approach

We build dynamic models of community assembly by starting with one species in our model ecosystem and adding colonists. We find that the number of species present first increases, then fluctuates about some level. We ask: how large are these fluctuations and how can we characterize them statistically? As in Robert May's work, communities with weaker interspecific interactions permit a greater number of species to coexist on average. We find that as this average increases, however, the relative variation in the number of species and return times to mean community levels decreases. In addition, the relative frequency of large extinction events to small extinction events decreases as mean community size increases. While the model reproduces several of May's results, it also provides theoretical support for Charles Elton's idea that diverse communities such as those found in the tropics should be less variable than depauperate communities such as those found in arctic or agricultural settings.

Deformation-induced grain growth and twinning in nanocrystalline palladium thin films

The microstructure and mechanical properties of nanocrystalline Pd films prepared by magnetron sputtering have been investigated as a function of strain. The films were deposited onto polyimide substrates and tested in tensile mode. In order to follow the deformation processes in the material, several samples were strained to defined straining states, up to a maximum engineering strain of 10%, and prepared for post-mortem analysis. The nanocrystalline structure was investigated by quantitative automated crystal orientation mapping (ACOM) in a transmission electron microscope (TEM), identifying grain growth and twinning/detwinning resulting from dislocation activity as two of the mechanisms contributing to the macroscopic deformation. Depending on the initial twin density, the samples behaved differently. For low initial twin densities, an increasing twin density was found during straining. On the other hand, starting from a higher twin density, the twins were depleted with increasing strain. The findings from ACOM-TEM were confirmed by results from molecular dynamics (MD) simulations and from conventional and in-situ synchrotron X-ray diffraction (CXRD, SXRD) experiments.

First-principles study of the electronic and magnetic properties of defective carbon nanostructures

149 p.: graf.

Diário da Constituinte [gravação de vídeo] : [programa n. 247] 

Na Comissão de Sistematização da Assembleia Nacional Constituinte (ANC) recomeça a votação dos direitos individuais e coletivos, que fazem parte do primeiro capítulo do Título II do substitutivo. Hoje a votação começou pelo §6º que garante a liberdade de culto e a liberdade de consciência e de crença. O parágrafo foi aprovado com a inclusão da emenda do Deputado Artur da Távola (PMDB-RJ) que pediu a retirada da expressão “que não contrariem a ordem pública e os bons costumes”. Aprovado sem nenhuma alteração o § 7º que trata da liberdade de locomoção no território brasileiro em tempo de paz. A seguir foi votado o §8º, no qual se afirma que a tortura e tráfico ilícito de drogas são considerados crimes inafiançáveis, imprescritíveis e insuscetíveis de concessão de anistia. O Deputado José Tavares (PMDB-PR) não concorda com o texto aprovado, que não torna crime inafiançável o tráfico de drogas. Votado também o § 9º, que trata do livre exercício de qualquer trabalho, observadas as qualificações profissionais que a lei exigir. Estudantes de comunicação se manifestaram no Congresso pela obrigatoriedade do diploma para o exercício da profissão de jornalista. O estudante de comunicação Elton Antunes informa que a luta pelo diploma faz parte de uma luta mais ampla, que é a democratização dos meios de comunicação. O Deputado Antônio Brito (PMDB-RS) é favorável à exigência de diploma para o profissional de comunicação, esclarecendo que não se trata de defender apenas o interesse do jornalista, mas de toda a sociedade. A Deputada Beth Azize (PSB-AM) informa que cada um tem que estar perfeitamente habilitado para exercer sua profissão com responsabilidade. O Deputado Rodrigues Palma (PMDB-MT) apresentou uma emenda contra o diploma profissional para jornalista, que foi rejeitada, sendo mantido o texto do substitutivo que garante a qualificação profissional para todas as profissões. O Deputado Joaci Góes(PMDB-BA) discorda do texto aprovado, em relação a exigência de diploma para jornalistas.

Elasmobranchs as living resources: Advances in the biology, ecology, systematics, and the status of the fisheries

This report owes its genesis to the foresight and enthusiam of Dr. Kazuhiro Mizue. By happy circumstance, Professor Mizue contacted me in 1983 with his visionary ideas on cooperative programs. He noted that the time was right because the Japan Society for the Promotion of Science and the National Science Foundation had mutually given priority to cooperative programs in marine biology. I therefore agreed to act as the U.S. coordinator and proposed to NSF, a short trip to Japan to negotiate site visits and timing with ten previously appointed Japanese scientists and, if that trip were successful, to negotiate a joint research project, possibly followed by a joint seminar. (PDF file contains 528 pages.)