Are invasive marsh frogs (Pelophylax ridibundus) replacing the native P. lessonae /P. esculentus hybridogenetic complex in Western Europe? Genetic evidence from a field study.

The water-frog L-E system, widespread in Western Europe, comprises the pool frog Pelophylax lessonae and the hybridogenetic edible frog P. esculentus, which originated from hybridization between pool frogs and marsh frogs (P. ridibundus). In P. esculentus, the lessonae (L) genome is eliminated during meiosis and has to be gained anew each generation from a P. lessonae partner, while the ridibundus (R') genome is transmitted clonally. It therefore accumulates deleterious mutations, so that R'R' offspring from P. esculentus x P. esculentus crosses are normally unviable. This system is now threatened by invasive P. ridibundus (RR) imported from Eastern Europe and the Balkans. We investigated the genetic interactions between invasive marsh frogs and native water frogs in a Swiss wetland area, and used genetic data collected in the field to validate several components of a recently postulated mechanism of species replacement. We identified neo-ridibundus individuals derived from crosses between invasive ridibundus and native esculentus, as well as newly arisen hybridogenetic esculentus lineages stemming from crosses between invasive ridibundus (RR) and native lessonae (LL). As their ridibundus genomes are likely to carry less deleterious mutations, such lineages are expected to produce viable ridibundus offspring, contributing to species replacement. However, such crosses with invasive ridibundus only occurred at a limited scale; moreover, RR x LL crosses did not induce any introgression from the ridibundus to the lessonae genome. We did not find any ridibundus stemming from crosses between ancient esculentus lineages. Despite several decades of presence on the site, introduced ridibundus individuals only represent 15% of sampled frogs, and their spatial distribution seems shaped by specific ecological requirements rather than history of colonization. We therefore expect the three taxa to coexist stably in this area.

Marsh rainbow arch bridges in Iowa, 1997

The Marsh Rainbow Arch Bridge is a patented bridge design by James Barney Marsh, a graduate of Iowa State College of Agriculture and Mechanic Arts (now Iowa State University). Around the turn of the 20th Century, reinforced concrete was introduced in Iowa as an important new bridge construction material. Marsh used the new technology to encased steel truss arches in concrete to produce a sturdy yet esthetic arch bridge. This booklet touches on the important aspects of Marsh's life, business and industrial contributions.

Role of habitat in the distribution and abundance of marsh birds, 1965

This is Special Report no. 43 that studies habitat changes and the affects on marsh birds. It covers the history of vegetation and birds of two marshes, Little Wall and Goose Lake, in Iowa for a 5-year period beginning in 1958 at the culmination of a series of drought years in central Iowa.

Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data.

BACKGROUND: Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong sub-region and poses a major global public health threat. Slow parasite clearance is a key clinical manifestation of reduced susceptibility to artemisinin. This study was designed to establish the baseline values for clearance in patients from Sub-Saharan African countries with uncomplicated malaria treated with artemisinin-based combination therapies (ACTs). METHODS: A literature review in PubMed was conducted in March 2013 to identify all prospective clinical trials (uncontrolled trials, controlled trials and randomized controlled trials), including ACTs conducted in Sub-Saharan Africa, between 1960 and 2012. Individual patient data from these studies were shared with the WorldWide Antimalarial Resistance Network (WWARN) and pooled using an a priori statistical analytical plan. Factors affecting early parasitological response were investigated using logistic regression with study sites fitted as a random effect. The risk of bias in included studies was evaluated based on study design, methodology and missing data. RESULTS: In total, 29,493 patients from 84 clinical trials were included in the analysis, treated with artemether-lumefantrine (n = 13,664), artesunate-amodiaquine (n = 11,337) and dihydroartemisinin-piperaquine (n = 4,492). The overall parasite clearance rate was rapid. The parasite positivity rate (PPR) decreased from 59.7 % (95 % CI: 54.5-64.9) on day 1 to 6.7 % (95 % CI: 4.8-8.7) on day 2 and 0.9 % (95 % CI: 0.5-1.2) on day 3. The 95th percentile of observed day 3 PPR was 5.3 %. Independent risk factors predictive of day 3 positivity were: high baseline parasitaemia (adjusted odds ratio (AOR) = 1.16 (95 % CI: 1.08-1.25); per 2-fold increase in parasite density, P <0.001); fever (>37.5 °C) (AOR = 1.50 (95 % CI: 1.06-2.13), P = 0.022); severe anaemia (AOR = 2.04 (95 % CI: 1.21-3.44), P = 0.008); areas of low/moderate transmission setting (AOR = 2.71 (95 % CI: 1.38-5.36), P = 0.004); and treatment with the loose formulation of artesunate-amodiaquine (AOR = 2.27 (95 % CI: 1.14-4.51), P = 0.020, compared to dihydroartemisinin-piperaquine). CONCLUSIONS: The three ACTs assessed in this analysis continue to achieve rapid early parasitological clearance across the sites assessed in Sub-Saharan Africa. A threshold of 5 % day 3 parasite positivity from a minimum sample size of 50 patients provides a more sensitive benchmark in Sub-Saharan Africa compared to the current recommended threshold of 10 % to trigger further investigation of artemisinin susceptibility.

Estimation of Water Circulation in a Mediterranean Salt Marsh and its Relationship with Flooding Causes

Variations in water volume in small depressions in Mediterranean salt marshes in Girona (Spain) are described and the potential causes for these variations analysed. Although the basins appear to be endorrheic, groundwater circulation is intense, as estimated from the difference between water volume observed and that expected from the balance precipitation / evaporation. The rate of variation in volume (VR = AV / VAt) may be used to estimate groundwater supply ('circulation'), since direct measurements of this parameter are impossible. Volume.conductivity figures can also be used to estimate the quantity of circulation, and to investigate the origin of water supplied to the system. The relationships between variations in the volume of water in the basins and the main causes of flooding are also analysed. Sea storms, rainfall levels and strong, dry northerly winds are suggested as the main causes of the variations in the volumes of basins. The relative importance assigned to these factors has changed, following the recent regulation of freshwater flows entering the system

Haastattelussa : professori, tanssikriitikko, kirjailija Elizabeth Kendall

Haasteltavana professori, tanssikriitikko ja kirjailija Elizabeth Kendall.

« La liste des seigneurs, barons, chevaliers et gentilshommes, envoyez en France par Elizabeth, royne d'Angleterre, pour confirmer la ligue d'entre le très victorieux et très magnanime roy, Charles neufiesme, et ladicte dame, à present regnantz ».

Tel est le titre qu'on lit au r° du feuillet 1 de ce volume. Au bas de ce feuillet on a ajouté, faisant allusion aux membres de cette ambassade : « Arrivez à Paris le 8 juin 1572 ». Les feuillets 2-4 sont occupés par un prologue adressé « au roy » Charles IX, par l'auteur de cette liste, lequel se dit « son très humble serviteur, secretaire et historiographe ès langues angloise, galoise, irlandoise et escossoise », et signe : « JEHAN BENARD ». Les feuillets 5 à 25 donnent des noms des principaux personnages de cette ambassade, à commencer par l'ambassadeur, « le comte de Lyncolne,... Edouard Fines,... admiral d'Angleterre », de courtes notices, précédées pour la plupart de leurs noms et de leurs armoiries peintes. « Les gentilz hommes de moindre degré et condition que les susnommez », sont simplement énumérés ; après quoi l'auteur termine ainsi : «... Oultre les susnommez seigneurs, barons, chevaliers et gentilz-hommes, monsieur l'admiral a à sa suite XXXV gentilzhommes de sa maison » et « ses autres serviteurs, appellez Yemen, par terme du païs, reduitz au nombre de XXXVI », lesquels « ont pareilz manteaux de livrée » que les gentilshommes de sa maison, « mais au lieu de veloux, ilz ont une bande de drap noir sur chasque manteau avec passement rouge ». Lettres ornées, armoiries peintes.

Welland Canal Survey of Lands Widow Elizabeth Ball, 1834

Survey map and description of Widow Elizabeth Ball's land created by The Welland Canal Company. Included is a written description of the land along with a drawing of the land. Noteable features include; locks no. 28, 29, 30, 31, line between Widow Ball and Thomas Ker's land, township line between Grantham and Thorold, waste weir. Surveyor notes are seen in pencil on the map. The land was originally surveyed in 1826(?) and then re-surveyed on November 28th, 1834. The land was used by the Welland Canal Company for canal and hydraulic purposes and was located in lot 9 in the 10th concession of Grantham township.