Crystal cataracts: Human genetic cataract caused by protein crystallization

Several human genetic cataracts have been linked recently to point mutations in the γD crystallin gene. Here we provide a molecular basis for lens opacity in two genetic cataracts and suggest that the opacity occurs because of the spontaneous crystallization of the mutant proteins. Such crystallization of endogenous proteins leading to pathology is an unusual event. Measurements of the solubility curves of crystals of the Arg-58 to His and Arg-36 to Ser mutants of γD crystallin show that the mutations dramatically lower the solubility of the protein. Furthermore, the crystal nucleation rate of the mutants is enhanced considerably relative to that of the wild-type protein. It should be noted that, although there is a marked difference in phase behavior, there is no significant difference in protein conformation among the three proteins.

Boston & Maine Railroad, 1849 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of the Boston & Maine Railroad : published by order of the Legislature of Massachusetts, showing its relative position & connection with other railroads, prepared by order of the Committee of Investigation ; Wm. P. Parrott, engineer ; George B. Parrott, del. It was published in July 1849 by W.C. Sharp's Lith. Scale [ca. 1:162,925]. Covers area from Portland, Me. to Boston, Mass. and west to Concord, N.H.The image inside the map neatline is georeferenced to the surface of the earth and fit to the USA Contiguous Albers Equal Area Conic projection (Meters). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, state, county and selected town boundaries, and more.This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Manufacturing developments in Argentina.

"Principal sources": p. 25-26.

Annual report /

Commissioners: 1867-1871, George B. Wright.--1871-1872, Richard D. Harrision.--1872-1874, Orlow L. Wolcott.--1874-1876, John G. Thompson.--1876-1878, Lincoln G. Delano.--1878-1880. William Bell, Jr.--1880-1881, James S. Robinson.--1881-1885, Hylas Sabine.--1885-1887, Henry Apthorp.--1887-1890, William S. Cappeller.--1890-1892, James A. Norton.--1892-1897, William Kirkby.--1897-1901, Raymond S. Kayler.--1901-1906, James C. Morris.

Potatoes : acreage, production, value, farm dispositon, Jan. 1 stocks (1866-1950)

Mode of access: Internet.

Supplement to Arthur's Manual of the rusts in United States and Canada.

Mode of access: Internet.

Nutritional physiology of the adult ruminant,

Bibliographical foot-notes.

A plan for regional cooperation: public information and education for highway safety including communication plans and strategies. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Minty and the cavalry. A history of cavalry campaigns in the western armies.

Includes rosters of officers of the 4th Mich., 7th Pa., 4th U.S. and 9th Pa. cavalry. A dozen or more other regiments were, at one time or another attached to the brigade.

Das illustrirte Mississippithal : dargestellt in 80 nach der Natur aufgenommenen Ansichten vom Wasserfalle zu St. Anthony an bis zum Golf von Mexico (eine Entfernung von ungefähr 2300 englischen Meilen) /

Cf. Sabin 40807.

Folk-songs of England,

Pl. no.: 12593, 13678, 12993, 13587, 13652.

TRIPCAL5 documentation manual, revised edition.

Texas Department of Transportation, Austin

Modal cities /

Includes bibliographical references.

Engravings from the works of Sir Joshua Reynolds, P.R.A. /

Mounted mezzotint engravings after portraits by Sir Joshua Reynolds, executed mainly by Samuel William Reynolds and by numerous other engravers: Richard Parkes Bonington, W.A. Rainger, Frederik Bromley, George H. Every, James Scott, George Sanders, A. Sanders, Joseph W. Edwards, John Richardson Jackson, R. José, H.C. Balding, Charles Tomkins, George Salisbury Shury, Richard Josey, Charles Algernon Tomkins, Arthur Turrell, William Henry Egleton, A.N. Sanders, William T. Hulland, T. Hunt, Stephen H. Gimber, H. Davis, Edwin Hunt, Thomas Lewis Atkinson, T. José, A. Scott.

Digest of the decisions of law and practice in the Patent Office from 1880 to 1890 /

Mode of access: Internet.