The whaling issue: Conservation, confusion, and casuistry

Morishita’s “multiple analysis”of the whaling issue [Morishita J. Multiple analysis of the whaling issue: Understanding the dispute by a matrix. Marine Policy 2006;30:802–8] is essentially a restatement of the Government of Japan’s whaling policy, which confuses the issue through selective use of data, unsubstantiated facts, and the vilification of opposing perspectives. Here, we deconstruct the major problems with Morishita’s article and provide an alternative view of the whaling dispute. For many people in this debate, the issue is not that some whales are not abundant, but that the whaling industry cannot be trusted to regulate itself or to honestly assess the status of potentially exploitable populations. This suspicion has its origin in Japan’s poor use of science, its often implausible stock assessments, its insistence that culling is an appropriate way to manage marine mammal populations, and its relatively recent falsification of whaling and fisheries catch data combined with a refusal to accept true transparency in catch and market monitoring. Japanese policy on whaling cannot be viewed in isolation, but is part of a larger framework involving a perceived right to secure unlimited access to global marine resources. Whaling is inextricably tied to the international fisheries agreements on which Japan is strongly dependent; thus, concessions made at the IWC would have potentially serious ramifications in other fora.

El modelo "productivo con inclusión social" : una modalidad de redistribución de ingresos manteniendo la concentración de la riqueza

La crisis orgánica y la rebelión popular marcaron el final del modelo neoliberal y la génesis del modelo «productivo con inclusión social». El bloque dominante se propuso: 1. Recomponer el poder del Estado. 2. Recuperar el crecimiento económico para garantizar la acumulación capitalista. 3. Dirimir la disputa por la hegemonía entre sectores del bloque dominante y asegurar el control del bloque subalterno. Se realizaron concesiones a los sectores populares sin atenuar la concentración y extranjerización económicas, ni la depredación de recursos naturales no renovables. No existe una real redistribución de la propiedad de la riqueza, sino una distribución de los ingresos entre sectores asalariados.

Brain dynamics of mild cognitive impairment during face encoding

Brain oscillations are closely correlated with human information processing and fundamental aspects of cognition. Previous literature shows that due to the relation between brain oscillations and memory processes, spectral dynamics during such tasks are good candidates to study and characterize memory related pathologies. Mild cognitive impairment (MCI), defined as a clinical condition characterized by memory impairment and/ or deterioration of additional cognitive domains, is considered a preliminary stage in the dementia process. In consequence, the study of its brain patterns could help to achieve an early diagnosis of Alzheimer Disease.

Contribuição à história dos batistas Sul-Mato-grossenses a partir da memória coletiva Um Recorte Biográfico da missionária Ann Mae Louise Wollerman

Esta pesquisa parte do interesse de análise da contribuição da missionária Ana Wollerman para o crescimento da denominação batista no sul de Mato Grosso e Mato Grosso do Sul, no período compreendido entre os anos de 1948 a 1978. A memória religiosa e autobiográfica da missionária apresenta experiências com o sagrado que marcam divisores de fases e temporalidades no seu recorte biográfico e que influenciam decisivamente na postura ministerial adotada. As entrevistas com algumas pessoas que participaram das comunidades afetivas existentes e os registros nas atas lidas constatam em grande parte os dados coletados pela memória. Ana Wollerman, filha de descendentes de alemães nos E.U.A., graduou-se em Artes e pósgraduou- se em Educação Religiosa. Veio para o Brasil inicialmente como missionária sem depender do sustento financeiro de uma Junta Missionária, fundou diversas escolas de ensino primário, trabalhou na implantação de diversas igrejas e dedicou grande parte de seus esforços no ensino ministerial. Foi responsável pela ajuda financeira no sustento de mais de uma dezena de jovens nos Seminários de Curitiba-PR, no IBER-RJ e no Seminário do Sul-RJ. Contribuiu também para que fossem destinadas grandes ofertas para a construção do Seminário Teológico Batista em Dourados. O trabalho procura seguir uma metodologia ainda em construção no que se refere à memória religiosa e utiliza o referencial teórico de Maurice Halbwachs para apresentar as memórias individuais e construção da memória coletiva, bem como tem apoio no próprio Halbwachs ao trabalhar a leitura da formação das comunidades afetivas. Aliado a estas questões se presta como um primeiro tratado sobre a historiografia da denominação batista em Mato Grosso e Mato Grosso do Sul, reunindo aspectos da sua gênese e do seu desenvolvimento. O resgate e a valorização da memória do sujeito-objeto em questão, ainda em vida constitui também no reconhecimento que a academia pode prestar às pessoas e às comunidades que se dedicam à construção de um mundo melhor.(AU)

Contribuição à história dos batistas Sul-Mato-grossenses a partir da memória coletiva Um Recorte Biográfico da missionária Ann Mae Louise Wollerman

Esta pesquisa parte do interesse de análise da contribuição da missionária Ana Wollerman para o crescimento da denominação batista no sul de Mato Grosso e Mato Grosso do Sul, no período compreendido entre os anos de 1948 a 1978. A memória religiosa e autobiográfica da missionária apresenta experiências com o sagrado que marcam divisores de fases e temporalidades no seu recorte biográfico e que influenciam decisivamente na postura ministerial adotada. As entrevistas com algumas pessoas que participaram das comunidades afetivas existentes e os registros nas atas lidas constatam em grande parte os dados coletados pela memória. Ana Wollerman, filha de descendentes de alemães nos E.U.A., graduou-se em Artes e pósgraduou- se em Educação Religiosa. Veio para o Brasil inicialmente como missionária sem depender do sustento financeiro de uma Junta Missionária, fundou diversas escolas de ensino primário, trabalhou na implantação de diversas igrejas e dedicou grande parte de seus esforços no ensino ministerial. Foi responsável pela ajuda financeira no sustento de mais de uma dezena de jovens nos Seminários de Curitiba-PR, no IBER-RJ e no Seminário do Sul-RJ. Contribuiu também para que fossem destinadas grandes ofertas para a construção do Seminário Teológico Batista em Dourados. O trabalho procura seguir uma metodologia ainda em construção no que se refere à memória religiosa e utiliza o referencial teórico de Maurice Halbwachs para apresentar as memórias individuais e construção da memória coletiva, bem como tem apoio no próprio Halbwachs ao trabalhar a leitura da formação das comunidades afetivas. Aliado a estas questões se presta como um primeiro tratado sobre a historiografia da denominação batista em Mato Grosso e Mato Grosso do Sul, reunindo aspectos da sua gênese e do seu desenvolvimento. O resgate e a valorização da memória do sujeito-objeto em questão, ainda em vida constitui também no reconhecimento que a academia pode prestar às pessoas e às comunidades que se dedicam à construção de um mundo melhor.(AU)

Contribuição à história dos batistas Sul-Mato-grossenses a partir da memória coletiva Um Recorte Biográfico da missionária Ann Mae Louise Wollerman

Esta pesquisa parte do interesse de análise da contribuição da missionária Ana Wollerman para o crescimento da denominação batista no sul de Mato Grosso e Mato Grosso do Sul, no período compreendido entre os anos de 1948 a 1978. A memória religiosa e autobiográfica da missionária apresenta experiências com o sagrado que marcam divisores de fases e temporalidades no seu recorte biográfico e que influenciam decisivamente na postura ministerial adotada. As entrevistas com algumas pessoas que participaram das comunidades afetivas existentes e os registros nas atas lidas constatam em grande parte os dados coletados pela memória. Ana Wollerman, filha de descendentes de alemães nos E.U.A., graduou-se em Artes e pósgraduou- se em Educação Religiosa. Veio para o Brasil inicialmente como missionária sem depender do sustento financeiro de uma Junta Missionária, fundou diversas escolas de ensino primário, trabalhou na implantação de diversas igrejas e dedicou grande parte de seus esforços no ensino ministerial. Foi responsável pela ajuda financeira no sustento de mais de uma dezena de jovens nos Seminários de Curitiba-PR, no IBER-RJ e no Seminário do Sul-RJ. Contribuiu também para que fossem destinadas grandes ofertas para a construção do Seminário Teológico Batista em Dourados. O trabalho procura seguir uma metodologia ainda em construção no que se refere à memória religiosa e utiliza o referencial teórico de Maurice Halbwachs para apresentar as memórias individuais e construção da memória coletiva, bem como tem apoio no próprio Halbwachs ao trabalhar a leitura da formação das comunidades afetivas. Aliado a estas questões se presta como um primeiro tratado sobre a historiografia da denominação batista em Mato Grosso e Mato Grosso do Sul, reunindo aspectos da sua gênese e do seu desenvolvimento. O resgate e a valorização da memória do sujeito-objeto em questão, ainda em vida constitui também no reconhecimento que a academia pode prestar às pessoas e às comunidades que se dedicam à construção de um mundo melhor.(AU)

The Re-Emergence of Suriname’s Désiré (Desi) Bouterse: Political Acumen and Geopolitical Anxiety

This study examines some concerns that derive from Suriname‘s May-July 2010 elections, which resulted in the re-emergence of erstwhile military ruler and convicted drug trafficker, Désiré (Desi) Bouterse, as President of the Republic. The victory reflects Bouterse‘s political acumen in aggregating disparate political interests and in establishing a viable coalition government. But because of his history and profile, this triumph has generated anxiety in some places internationally. In this respect, the study examines anxieties related to three matters: (a) relations with Guyana, where there is an existing territorial dispute and a recently resolved maritime dispute, (b) illegal drug trafficking operations, and (c) foreign policy engagement with Venezuela. There has been a flurry of bilateral activities—including several presidential summits—with Guyana since President Bouterse‘s inauguration, albeit seemingly more about symbolism than substance. Although the maritime dispute was settled by a Tribunal of the United Nations Convention of the Law of the Sea in 2007, the 15,000 km2 New River Triangle is still unresolved. Indeed, in June 2011 President Bouterse reasserted Suriname‘s claim to the Triangle. Suriname has upped the ante in that dispute by portraying internationally the map of Suriname as inclusive of the disputed area. In all likelihood that self-redefinition slowly will become the country‘s cartographic definition in the eyes of the world if Guyana does not successfully rebuff that move or pursue the definitive settlement of the dispute. A geonarcotics assessment shows Suriname to be still heavily implicated in trafficking, because of geography, law enforcement limitations, corruption, and other factors. But despite Bouterse‘s drug-related history and that of former senior military officers, several reasons suggest the inexpediency of a narco-state being created by Bouterse. As well, as part of Suriname‘s pursuit of increased Caribbean and South American engagement, it has boosted relations with Venezuela, which has included it in PetroCaribe and provided housing and agricultural aid. However, the engagement appears to be driven more by pragmatism and less by any ideological affinity with Hugo Chavez.

HOLDING HANDS WHILE PARTING WAYS: EXAMINING ALLIANCE TREATY RENEGOTIATION

This study investigates the renegotiation of security alliances, specifically the structural conditions surrounding their revision. Although the field of international relations offers a rich discussion of the formation and violation of alliance treaties, few scholars have addressed the reasons why alliance members amend security obligations. After the formation of an alliance, a member may become dissatisfied owing to changes in the external and domestic security environments. A failure to address this discontent increases the risk of alliance breakdown. Members manage their alliance relationship through a negotiation process or intra-alliance bargaining in the search for a new arrangement that can endure. Factors that help to show commitment to the alliance and communicate a set of feasible solutions are crucial if members are to find a mutually acceptable arrangement. By taking these factors into account, allies are more likely to revise an existing treaty. Examining a set of bilateral alliances dating from 1945 to 2001, this research demonstrates that public requests for renegotiation compel allies to change the status quo. It is found that alliance-related fixed assets and the formation of external alliances increase the likelihood of treaty revision, though institutionalization of an alliance does not help to resolve interest divergence. In addition, this study examines the strategy of delay in intra-alliance bargaining. Allies may postpone a dispute by ignoring it while working to maintain the alliance. Tension among allies thus increases, but the alliance endures. I examine three alliances in order to illustrate this renegotiation process. Among these, the Anglo-Japanese alliance demonstrates two successful renegotiations that prolonged a wavering alliance relationship; the Sino-Soviet alliance is an example of failure owing to the lack of substantive cooperation; and the US-Taiwan alliance during the 1970s demonstrates successful use of a strategy of delay that appeases a dissatisfied member.

Comportamiento de la participación electoral y su relación con las dinámicas de violencia política en Norte de Santander (1997-2011)

La investigación analiza el comportamiento de la participación electoral (PE) y su relación con las dinámicas de violencia política en Norte de Santander durante 1997-2011, con el fin de demostrar que la región del Catatumbo ha tenido un comportamiento electoral diferente al resto del departamento dado que tiene una tendencia en porcentajes de participación bajos durante las elecciones locales que se dieron en 1997, 2000 y 2003, lo cual se debe a la presencia y disputa por el control territorial entre los Grupos Armados Ilegales (GAI). Contrario a lo anterior, en las elecciones de 2007 y 2011 se presenta una variación positiva al aumentar la PE en el departamento en general. Se utilizará una combinación del método cuantitativo y cualitativo, el primero mediante un análisis de datos electorales de cinco comicios locales; el segundo, por medio de entre

Metabolic Memory Of ß-cells Controls Insulin Secretion And Is Mediated By Camkii.

Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) functions both in regulation of insulin secretion and neurotransmitter release through common downstream mediators. Therefore, we hypothesized that pancreatic ß-cells acquire and store the information contained in calcium pulses as a form of metabolic memory, just as neurons store cognitive information. To test this hypothesis, we developed a novel paradigm of pulsed exposure of ß-cells to intervals of high glucose, followed by a 24-h consolidation period to eliminate any acute metabolic effects. Strikingly, ß-cells exposed to this high-glucose pulse paradigm exhibited significantly stronger insulin secretion. This metabolic memory was entirely dependent on CaMKII. Metabolic memory was reflected on the protein level by increased expression of proteins involved in glucose sensing and Ca(2+)-dependent vesicle secretion, and by elevated levels of the key ß-cell transcription factor MAFA. In summary, like neurons, human and mouse ß-cells are able to acquire and retrieve information.

Relationship Between Cortisol Levels and Memory Performance may be Modulated by the Presence or Absence of Cognitive Impairment: Evidence from Healthy Elderly, Mild Cognitive Impairment and Alzheimer`s Disease Subjects

An inverted U-shape function between cortisol levels and memory performance has been reported in studies on both young animals and humans. Yet little is known about this relationship in normal aging or in older subjects with cognitive impairment. This issue is particularly significant since increased levels of cortisol have been reported in Alzheimer`s disease (AD). The present study examined the association between cortisol levels and visual memory performance in healthy subjects as well as in individuals presenting mild cognitive impairment (MCI) or AD. Salivary cortisol was measured in 40 healthy elderly subjects, 31 individuals with amnestic MCI, and 40 subjects with mild probable AD. Memory performance was evaluated using the Brief Cognitive Screening Battery. Higher cortisol levels were associated with better memory performance in healthy elderly (p = 0.005), while higher cortisol levels were correlated with poorer memory performance in MCI subjects (p = 0.011). No correlation between cortisol and memory was found in the AD group (p > 0.05). These results suggest that the relationship between cortisol levels and memory performance in the aging process could vary according to the presence or absence of cognitive impairment.

Selective involvement of GABAergic mechanisms of the dorsal periaqueductal gray and inferior colliculus on the memory of the contextual fear as assessed by the fear potentiated startle test

The inferior colliculus (IC) together with the dorsal periaqueductal gray (dPAG), the amygdala and the medial hypothalamus make part of the brain aversion system, which has mainly been related to the organization of unconditioned fear. However, the involvement of the IC and dPAG in the conditioned fear is still unclear. It is certain that GABA has a regulatory role on the aversive states generated and elaborated in these midbrain structures. In this study, we evaluated the effects of injections of the GABA-A receptor agonist muscimol (1.0 and 2.0 nmol/0.2 mu L) into the IC or dPAG on the freezing and fear-potentiated startle (FPS) responses of rats submitted to a context fear conditioning. Intra-IC injections of muscimol did not cause any significant effect on the FPS or conditioned freezing but enhanced the startle reflex in non-conditioned animals. In contrast, intra-dPAG injections of muscimol caused significant reduction in FPS and conditioned freezing without changing the startle reflex in non-conditioned animals. Thus, intra-dPAG injections of muscimol produced the expected inhibitory effects on the anxiety-related responses, the FPS and the freezing whereas these injections into the IC produced quite opposite effects suggesting that descending inhibitory pathways from the IC, probably mediated by GABA-A mechanisms, exert a regulatory role on the lower brainstem circuits responsible for the startle reflex. (C) 2008 Elsevier Inc. All rights reserved.

Provision of 4-1BB ligand enhances effector and memory CTL responses generated by immunization with dendritic cells expressing a human tumor-associated antigen

Up-regulation of receptor-ligand pairs during interaction of an MHC-presented epitope on dendritic cells (DCs) with cognate TCR may amplify, sustain, and drive diversity in the ensuing T cell immune response. Members of the TNF ligand superfamily and the TNFR superfamily contribute to this costimulatory molecule signaling. In this study, we used replication deficient adenoviruses to introduce a model tumor-associated Ag (the E7 oncoprotein of human papillomavirus 16) and the T cell costimulatory molecule 4-IBBL into murine DCs, and monitored the ability of these recombinant DO to elicit E7-directed T cell responses following immunization. Splenocytes from mice immunized with DCs expressing E7 alone elicited E7-directed effector and memory CTL responses. Coexpression of 4-1BBL in these E7-expressing DO increased effector and memory CTL responses when they were used for immunization. 4-1BBL expression up-regulated CD80 and CD86 second signaling molecules in DO. We also report an additive effect of 4-IBBL and receptor activator of NF-kappaB/receptor activator of NF-kappaB ligand coexpression in E7-transduced DC inummogens on E7-directed effector and memory CTL responses and on MHC class II and CD80/86 expression in DCs. Additionally, expression of 4-1BBL in E7-transduced DCs reduced nonspecific T cell activation characteristic of adenovirus vector-associated immunization. The results have generic implications for improved or tumor Ag-expressing DC vaccines by incorporation of exogenous 4-1BBL. There are also specific implications for an improved DC-based vaccine for human papillomavirus 16-associated cervical carcinoma.

Enhanced effector and memory CTL responses generated by incorporation of receptor activator of NF-kappa B(RANK)/RANK ligand costimulatory molecules into dendritic cell immunogens expressing a human tumor-specific antigen

The outcome of dendritic cell (DC) presentation of Ag to T cells via the TCR/MHC synapse is determined by second signaling through CD80/86 and, importantly, by ligation of costimulatory ligands and receptors located at the DC and T cell surfaces. Downstream signaling triggered by costimulatory molecule ligation results in reciprocal DC and T cell activation and survival, which predisposes to enhanced T cell-mediated immune responses. In this study, we used adenoviral vectors to express a model tumor Ag (the E7 oncoprotein of human papillomavirus 16) with or without coexpression of receptor activator of NF-kappaB (RANK)/RANK ligand (RANKL) or CD40/CD40L costimulatory molecules, and used these transgenic DCs to immunize mice for the generation of E7-directed CD8(+) T cell responses. We show that coexpression of RANK/RANKL, but not CD40/CD40L, in E7-expressing DCs augmented E7-specific IFN-gamma-secreting effector and memory T cells and E7-specific CTLs. These responses were also augmented by coexpression of T cell costimulatory molecules (RANKL and CD40L) or DC costimulatory molecules (RANK and CD40) in the E7-expressing DC immunogens. Augmentation of CTL responses correlated with up-regulation of CD80 and CD86 expression in DCs transduced with costimulatory molecules, suggesting a mechanism for enhanced T cell activation/survival. These results have generic implications for improved tumor Ag-expressing DC vaccines, and specific implications for a DC-based vaccine approach for human papillomavirus 16-associated cervical carcinoma.

Speculative execution by using software transactional memory

Dissertação apresentada na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa para a obtenção do Grau de Mestre em Engenharia Informática.