El problema de la condición de persona aplicada a los animales no humanos : Antropocentrismo especista, subjetividad y derecho

En este trabajo de tesis de grado buscaremos indagar, desde una perspectiva no-antropocéntrica, una temática contemporánea y de plena actualidad, que se está produciendo en las sociedades occidentales. Se trata del problema de la condición de persona aplicada a animales no humanos, enfocándonos principalmente en tres ejes de análisis: como hemos dicho, la noción de persona, el antropocentrismo especista, y la noción de sujeto. El marco general para pensar estas cuestiones es el cambio de perspectiva en la filosofía y en la ciencia, que comienza a darse con mayor ímpetu desde el último tercio del s. XX. Este cambio en el marco conceptual general, puede entenderse como una crisis en la forma de pensar al ser humano y su relación con el mundo no humano. Este cambio, a su vez, repercute en la sociedad en términos de la emergencia de nuevas reivindicaciones, entre ellas, la de los animales como sujetos de derecho y la plausibilidad de adscribir a algunos de ellos la condición de persona a partir de una serie de características que comparten con los seres humanos. ;Antes de proseguir, consideremos lo siguiente. Tal como señaló Niko Tinbergen con su "¿Qué pregunta, preguntas?" (Stamp Dawkins, 2007) resulta fundamental formular claramente la pregunta que guía nuestras hipótesis de trabajo, para dar cuenta de su sentido. De esta manera, explicitaremos la pregunta desde la que partimos, a saber, ¿Qué pone en juego o en duda la hipótesis de antropocentrismo especista y la de sujeto y persona aplicada a animales no humanos? Claramente es una cuestión compleja. No la abordaremos en la infinidad de sus aristas y derivaciones. Aun así, buscaremos un recorrido temático para pensar las dificultades que se imponen en este tópico contemporáneo

El problema de la condición de persona aplicada a los animales no humanos : Antropocentrismo especista, subjetividad y derecho

En este trabajo de tesis de grado buscaremos indagar, desde una perspectiva no-antropocéntrica, una temática contemporánea y de plena actualidad, que se está produciendo en las sociedades occidentales. Se trata del problema de la condición de persona aplicada a animales no humanos, enfocándonos principalmente en tres ejes de análisis: como hemos dicho, la noción de persona, el antropocentrismo especista, y la noción de sujeto. El marco general para pensar estas cuestiones es el cambio de perspectiva en la filosofía y en la ciencia, que comienza a darse con mayor ímpetu desde el último tercio del s. XX. Este cambio en el marco conceptual general, puede entenderse como una crisis en la forma de pensar al ser humano y su relación con el mundo no humano. Este cambio, a su vez, repercute en la sociedad en términos de la emergencia de nuevas reivindicaciones, entre ellas, la de los animales como sujetos de derecho y la plausibilidad de adscribir a algunos de ellos la condición de persona a partir de una serie de características que comparten con los seres humanos. ;Antes de proseguir, consideremos lo siguiente. Tal como señaló Niko Tinbergen con su "¿Qué pregunta, preguntas?" (Stamp Dawkins, 2007) resulta fundamental formular claramente la pregunta que guía nuestras hipótesis de trabajo, para dar cuenta de su sentido. De esta manera, explicitaremos la pregunta desde la que partimos, a saber, ¿Qué pone en juego o en duda la hipótesis de antropocentrismo especista y la de sujeto y persona aplicada a animales no humanos? Claramente es una cuestión compleja. No la abordaremos en la infinidad de sus aristas y derivaciones. Aun así, buscaremos un recorrido temático para pensar las dificultades que se imponen en este tópico contemporáneo

DE UMA CRISE A OUTRA, DE UM DARWINISMO A OUTRO: A IMPLANTAÇÃO DA PROGRESSÃO CONTINUADA NO ESTADO DE SÃO PAULO

O presente trabalho investiga a implantação do regime de progressão continuada nas escolas públicas do estado de São Paulo em 1998, de modo que tem como eixo de pesquisa e reflexões a política pública progressão continuada e seu processo de implantação e implementação. Houve o uso de duas linhas de pesquisa: pesquisa bibliográfica e pesquisa e análise do discurso oficial, não somente aquele que implanta o regime citado, mas também a gradação das leis e suas características. O suporte central de pesquisa apoia-se em duas consagradas obras: “A estrutura das revoluções científicas” e “A origem das espécies”, de Thomas Kuhn e Charles Darwin, respectivamente. As obras citadas farão jus ao título desse trabalho, a qual utiliza das discussões propostas por Kuhn sobre ‘crise’, tendo esta como uma das linhas mestras para analisar os períodos pré e pós implantação do regime combinado ao darwinismo, que aqui se denomina darwinismo pedagógico. Para estabelecer uma conexão entre o objeto central de pesquisa e as obras acima citadas, houve a necessidade de pesquisar e discutir temáticas diretamente relacionadas, como ‘um rio e seus afluentes’. Os ‘afluentes’ pesquisados e discutidos foram: pedagogia e ciência, regime de seriação, darwinismo, metáfora, políticas públicas, gradação das leis, identidade, resistência e desistência. Os ‘afluentes’ não ficaram restritos a pesquisa bibliográfica, houve a necessidade de também no discurso oficial realizar esta linha metodológica. A pesquisa revelou que a partir das contribuições de Kuhn, a implantação do regime de progressão continuada nas escolas públicas do estado de São Paulo apenas fez com que a educação no estado saísse de uma crise e entrasse em outra. Além disso, revelou também que o darwinismo pedagógico que imperava no regime de seriação, muda de face no regime de progressão continuada, porém continua ativo, agora afetando diretamente os docentes, que resistem ativamente ou em oposição, ou desistem, seja de forma anunciada ou velada.

La nécessité d'une multiplicité de concepts de gène en biologie

Le concept de gène est central en biologie. Certains ont avancé (Ruse (1971, 1976)) que la génétique classique pouvait être réduite à la génétique moléculaire. Dans le même ordre d'idée, Richard Dawkins, dans The Extended Phenotype, offre une double définition de son concept de gène qui présuppose qu'il soit possible d'opérer cette réduction. Nous comptons montrer que la génétique moléculaire et la génétique des populations ont chacune leurs problématiques propres en reconstituant l'histoire de la génétique depuis Darwin. Ensuite, nous expliciterons la position de Dawkins et soulignerons les contradictions auxquelles il parvient en raison de cette réduction infondée. À la suite de quoi, nous nous attarderons aux nouvelles découvertes moléculaires qui montrent qu'il n'est pas possible d'opérer la réduction d'un des concepts à l'autre. Nous terminerons en soulignant que la thèse génocentriste de Dawkins n'est pas mise en péril par l'abandon de la réduction, mais qu'il est nécessaire de tempérer ces prétentions. La conclusion globale de ce mémoire est qu'il est possible d'admettre le concept de Dawkins, mais pas la manière dont il l'utilise. Le concept est bon, il n'est tout simplement pas dans le bon cadre théorique.

La nécessité d'une multiplicité de concepts de gène en biologie

Le concept de gène est central en biologie. Certains ont avancé (Ruse (1971, 1976)) que la génétique classique pouvait être réduite à la génétique moléculaire. Dans le même ordre d'idée, Richard Dawkins, dans The Extended Phenotype, offre une double définition de son concept de gène qui présuppose qu'il soit possible d'opérer cette réduction. Nous comptons montrer que la génétique moléculaire et la génétique des populations ont chacune leurs problématiques propres en reconstituant l'histoire de la génétique depuis Darwin. Ensuite, nous expliciterons la position de Dawkins et soulignerons les contradictions auxquelles il parvient en raison de cette réduction infondée. À la suite de quoi, nous nous attarderons aux nouvelles découvertes moléculaires qui montrent qu'il n'est pas possible d'opérer la réduction d'un des concepts à l'autre. Nous terminerons en soulignant que la thèse génocentriste de Dawkins n'est pas mise en péril par l'abandon de la réduction, mais qu'il est nécessaire de tempérer ces prétentions. La conclusion globale de ce mémoire est qu'il est possible d'admettre le concept de Dawkins, mais pas la manière dont il l'utilise. Le concept est bon, il n'est tout simplement pas dans le bon cadre théorique.

UM Men's Swimming Team, 1983

Front Row: head coach Jon Urbanchek, Antonio Cerezo, Antonio Cohen, Benoit R. Clement, John Albanese, Kip Kimble, Bruce M. Gemmell, Kevin V. Williamson, Dave Mason, Bruce Kimball, Sam Lee, diving coach Dick Kimball.

Middle Row: Michael Gruber, Bill Eagan, Mike Fabian, Mike Hsi, Scott McKean, Kent Ferguson, Neal W. Bond, Harry N. Canales, Kirstan A. Vandersluis, Greg Dawkins, Mark Noetzel, Asst. coach Fernando Canales.

Back Row: Marc C. Parrish, Bruce Douglas, Jeff Wriston, Anthony Wallingford, John M. Andres, Roy Horning, Andrew R. Montague, Timothy P. Sheridan, Gary M. Antonick, Mike Mastic, manager Steve Roeder.

Essays and addresses,

Published in commemoration of the opening of the new college buildings, October 7th, 1873.

El problema de la condición de persona aplicada a los animales no humanos : Antropocentrismo especista, subjetividad y derecho

En este trabajo de tesis de grado buscaremos indagar, desde una perspectiva no-antropocéntrica, una temática contemporánea y de plena actualidad, que se está produciendo en las sociedades occidentales. Se trata del problema de la condición de persona aplicada a animales no humanos, enfocándonos principalmente en tres ejes de análisis: como hemos dicho, la noción de persona, el antropocentrismo especista, y la noción de sujeto. El marco general para pensar estas cuestiones es el cambio de perspectiva en la filosofía y en la ciencia, que comienza a darse con mayor ímpetu desde el último tercio del s. XX. Este cambio en el marco conceptual general, puede entenderse como una crisis en la forma de pensar al ser humano y su relación con el mundo no humano. Este cambio, a su vez, repercute en la sociedad en términos de la emergencia de nuevas reivindicaciones, entre ellas, la de los animales como sujetos de derecho y la plausibilidad de adscribir a algunos de ellos la condición de persona a partir de una serie de características que comparten con los seres humanos. ;Antes de proseguir, consideremos lo siguiente. Tal como señaló Niko Tinbergen con su "¿Qué pregunta, preguntas?" (Stamp Dawkins, 2007) resulta fundamental formular claramente la pregunta que guía nuestras hipótesis de trabajo, para dar cuenta de su sentido. De esta manera, explicitaremos la pregunta desde la que partimos, a saber, ¿Qué pone en juego o en duda la hipótesis de antropocentrismo especista y la de sujeto y persona aplicada a animales no humanos? Claramente es una cuestión compleja. No la abordaremos en la infinidad de sus aristas y derivaciones. Aun así, buscaremos un recorrido temático para pensar las dificultades que se imponen en este tópico contemporáneo

Lead time reduction for new products

The research, which was given the terms of reference, "To cut the lead time for getting new products into volume production", was sponsored by a company which develops and manufactures telecommunications equipment. The research described was based on studies made of the development of two processors which were designed to control telephone exchanges in the public network. It was shown that for each of these products, which were large electronic systems containing both hardware and software, most of their lead time was taken up with development. About half of this time was consumed by activities associated with redesign resulting from changes found to be necessary after the original design had been built. Analysing the causes of design changes showed the most significant to be Design Faults. The reasons why these predominated were investigated by seeking the collective opinion from design staff and their management using a questionnaire. Using the results from these studies to build upon the works of other authors, a model of the development process of large hierarchical systems is derived. An important feature of this model is its representation of iterative loops due to design changes. In order to reduce the development time, two closely related philosophies are proposed: By spending more time at the early stages of development (detecting and remedying faults in the design) even greater savings can be made later on, The collective performance of the development organisation would be improved by increasing the amount and speed of feedback about that performance. A trial was performed to test these philosophies using readily available techniques for design verification. It showed that about an 11 per cent saving would be made on the development time and that the philosophies might be equally successfully applied to other products and techniques.

Antiguas comunidades judías en Macedonia, Tracia y Épiro Superior

Evidencias de carácter literario, epigráfico y arqueológico-arquitectónicas, atestiguan la existencia de comunidades judías en Macedonia, Tracia y Épiro Superior (hoy Albania) durante los períodos romano y bizantino temprano. Los Hechos de los Apostoles mencionan la presencia de comunidades judías, y sus sinagogas, en Filipos, Tesalónica y Verroia, en Macedonia. El descubrimiento de inscripciones griegas en Bizya (Tracia), en Tesalónica y Dión, y en la antigua sinagoga de Stobia, sugieren que dichas comunidades preservaron su independencia religiosa y gozaron de un seguro estatus social, económico y cultural. Una antigua tumba judía encontrada en Tesalónica, decorada con una menorah, la sinagoga de Claudius Tiberius Polycharmos en Stobia y la de Saranda (Épiro Superior), añaden pruebas arqueológico- arquitectónicas a las fuentes literarias. A pesar de que las fuentes literarias, los datos epigráficos y los hallazgos arqueológicos son relativamente escasos, parece que en estas regiones, y en otras de la Península Balcánica, existieron también otras comunidades judías.

Associates of an elevated natriuretic peptide level in stable heart failure patients:implications for targeted management

BACKGROUND: Persistently elevated natriuretic peptide (NP) levels in heart failure (HF) patients are associated with impaired prognosis. Recent work suggests that NP-guided therapy can improve outcome, but the mechanisms behind an elevated BNP remain unclear. Among the potential stimuli for NP in clinically stable patients are persistent occult fluid overload, wall stress, inflammation, fibrosis, and ischemia. The purpose of this study was to identify associates of B-type natriuretic peptide (BNP) in a stable HF population.

METHODS: In a prospective observational study of 179 stable HF patients, the association between BNP and markers of collagen metabolism, inflammation, and Doppler-echocardiographic parameters including left ventricular ejection fraction (LVEF), left atrial volume index (LAVI), and E/e prime (E/e') was measured.

RESULTS: Univariable associates of elevated BNP were age, LVEF, LAVI, E/e', creatinine, and markers of collagen turnover. In a multiple linear regression model, age, creatinine, and LVEF remained significant associates of BNP. E/e' and markers of collagen turnover had a persistent impact on BNP independent of these covariates.

CONCLUSION: Multiple variables are associated with persistently elevated BNP levels in stable HF patients. Clarification of the relative importance of NP stimuli may help refine NP-guided therapy, potentially improving outcome for this at-risk population.

Natriuretic peptide-based screening and collaborative care for heart failure:the STOP-HF randomized trial

IMPORTANCE: Prevention strategies for heart failure are needed.

OBJECTIVE: To determine the efficacy of a screening program using brain-type natriuretic peptide (BNP) and collaborative care in an at-risk population in reducing newly diagnosed heart failure and prevalence of significant left ventricular (LV) systolic and/or diastolic dysfunction.

DESIGN, SETTING, AND PARTICIPANTS: The St Vincent's Screening to Prevent Heart Failure Study, a parallel-group randomized trial involving 1374 participants with cardiovascular risk factors (mean age, 64.8 [SD, 10.2] years) recruited from 39 primary care practices in Ireland between January 2005 and December 2009 and followed up until December 2011 (mean follow-up, 4.2 [SD, 1.2] years).

INTERVENTION: Patients were randomly assigned to receive usual primary care (control condition; n=677) or screening with BNP testing (n=697). Intervention-group participants with BNP levels of 50 pg/mL or higher underwent echocardiography and collaborative care between their primary care physician and specialist cardiovascular service.

MAIN OUTCOMES AND MEASURES: The primary end point was prevalence of asymptomatic LV dysfunction with or without newly diagnosed heart failure. Secondary end points included emergency hospitalization for arrhythmia, transient ischemic attack, stroke, myocardial infarction, peripheral or pulmonary thrombosis/embolus, or heart failure.

RESULTS: A total of 263 patients (41.6%) in the intervention group had at least 1 BNP reading of 50 pg/mL or higher. The intervention group underwent more cardiovascular investigations (control, 496 per 1000 patient-years vs intervention, 850 per 1000 patient-years; incidence rate ratio, 1.71; 95% CI, 1.61-1.83; P<.001) and received more renin-angiotensin-aldosterone system-based therapy at follow-up (control, 49.6%; intervention, 56.5%; P=.01). The primary end point of LV dysfunction with or without heart failure was met in 59 (8.7%) of 677 in the control group and 37 (5.3%) of 697 in the intervention group (odds ratio [OR], 0.55; 95% CI, 0.37-0.82; P = .003). Asymptomatic LV dysfunction was found in 45 (6.6%) of 677 control-group patients and 30 (4.3%) of 697 intervention-group patients (OR, 0.57; 95% CI, 0.37-0.88; P = .01). Heart failure occurred in 14 (2.1%) of 677 control-group patients and 7 (1.0%) of 697 intervention-group patients (OR, 0.48; 95% CI, 0.20-1.20; P = .12). The incidence rates of emergency hospitalization for major cardiovascular events were 40.4 per 1000 patient-years in the control group vs 22.3 per 1000 patient-years in the intervention group (incidence rate ratio, 0.60; 95% CI, 0.45-0.81; P = .002).

CONCLUSION AND RELEVANCE: Among patients at risk of heart failure, BNP-based screening and collaborative care reduced the combined rates of LV systolic dysfunction, diastolic dysfunction, and heart failure.

TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00921960.

Progression of left atrial volume index in a population at risk for heart failure:a substudy of the STOP-HF (St Vincent's Screening TO Prevent Heart Failure) trial

AIMS: Limited data are available concerning the evolution of the left atrial volume index (LAVI) in pre-heart failure (HF) patients. The aim of this study was to investigate clinical characteristics and serological biomarkers in a cohort with risk factors for HF and evidence of serial atrial dilatation.

METHODS AND RESULTS: This was a prospective substudy within the framework of the STOP-HF cohort (NCT00921960) involving 518 patients with risk factors for HF electively undergoing serial clinical, echocardiographic, and natriuretic peptide assessment. Mean follow-up time between assessments was 15 ± 6 months. 'Progressors' (n = 39) were defined as those with serial LAVI change ≥3.5 mL/m(2) (and baseline LAVI between 20 and 34 mL/m(2)). This cut-off was derived from a calculated reference change value above the biological, analytical, and observer variability of serial LAVI measurement. Multivariate analysis identified significant baseline clinical associates of LAVI progression as increased age, beta-blocker usage, and left ventricular mass index (all P < 0.05). Serological biomarkers were measured in a randomly selected subcohort of 30 'Progressors' matched to 30 'Non-progressors'. For 'Progressors', relative changes in matrix metalloproteinase 9 (MMP9), tissue inhibitor of metalloproteinase 1 (TIMP1), and the TIMP1/MMP9 ratio, markers of interstitial remodelling, tracked with changes in LAVI over time (all P < 0.05).

CONCLUSION: Accelerated LAVI increase was found to occur in up to 14% of all pre-HF patients undergoing serial echocardiograms over a relatively short follow-up period. In a randomly selected subcohort of 'Progressors', changes in LAVI were closely linked with alterations in MMP9, TIMP1, and the ratio of these enzymes, a potential aid in highlighting this at-risk group.

Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone

OBJECTIVES: This study was designed to evaluate the impact of eplerenone on collagen turnover in preserved systolic function heart failure (HFPSF).

BACKGROUND: Despite growing interest in abnormal collagen metabolism as a feature of HFPSF with diastolic dysfunction, the natural history of markers of collagen turnover and the impact of selective aldosterone antagonism on this natural history remains unknown.

METHODS: We evaluated 44 patients with HFPSF, randomly assigned to control (n = 20) or eplerenone 25 mg daily (n = 24) for 6 months, increased to 50 mg daily from 6 to 12 months. Serum markers of collagen turnover and inflammation were analyzed at baseline and at 6 and 12 months and included pro-collagen type-I and -III aminoterminal peptides, matrix metalloproteinase type-2, interleukin-6 and -8, and tumor necrosis factor-alpha. Doppler-echocardiographic assessment of diastolic filling indexes and tissue Doppler analyses were also obtained.

RESULTS: The mean age of the patients was 80 +/- 7.8 years; 46% were male; 64% were receiving an angiotensin-converting enzyme inhibitor, 34% an angiotensin-II receptor blocker, and 68% were receiving beta-blocker therapy. Pro-collagen type-III and -I aminoterminal peptides, matrix metalloproteinase type-2, interleukin-6 and -8, and tumor necrosis factor-alpha increased with time in the control group. Eplerenone treatment had no significant impact on any biomarker at 6 months but attenuated the increase in pro-collagen type-III aminoterminal peptide at 12 months (p = 0.006). Eplerenone therapy was associated with modest effects on diastolic function without any impact on clinical variables or brain natriuretic peptide.

CONCLUSIONS: This study demonstrates progressive increases in markers of collagen turnover and inflammation in HFPSF with diastolic dysfunction. Despite high background utilization of renin-angiotensin-aldosterone modulators, eplerenone therapy prevents a progressive increase in pro-collagen type-III aminoterminal peptide and may have a role in management of this disease. (The Effect of Eplerenone and Atorvastatin on Markers of Collagen Turnover in Diastolic Heart Failure; NCT00505336).