A new system of instruction in the Indian club exercise : containing a simple and accurate explanation of all the graceful motions as practiced by gymnasts, pubilists, etc.

Mode of access: Internet.

Behavior of ten-story reinforced concrete walls subjected to earthquake motions /

Mode of access: Internet.

On the motions of the earth and heavenly bodies, as explainable by electro-magnetic attraction and repulsion, and on the conception, growth, and decay of man, and cause and treatment of his diseases, as referable to galvanic action.

Mode of access: Internet.

The history and proceedings of the House of Lords from the Restoration in 1660 to the present time, containing the most remarkable motions, speeches, debates, orders and resolutions.

Title varies.

An essay on the forces which circulate the blood; being an examination of the difference of the motions of fluids in living and dead vessels.

Mode of access: Internet.

A compendium of astronomy : intended to simplify and illustrate the principles of the science : and give a concise view of the motions and aspects of the great heavenly luminaries : adapted to the use of common schools, as well as higher seminaries /

Includes index.

The history and proceedings of the House of Commons from the Restoration to the present time. Containing the most remarkable motions, speeches, resolves, reports and conferences to be met with in that interval: as also the most exact estimates of the charge of government, state of the public revenue, the rise and growth of the national debt, expence of the war, proceedings on ways and means, speeches and messages from the throne, addresses, and remonstrances, also the numbers pro and con upon every division &c. Many of which curious particulars were never before printed. Collected from the best authorities, compared with the journals of the House, and illustrated with a great variety of historical and explanatory notes. Together with a large appendix, containing exact lists of every Parliament, the names of the speakers, their several posts under the government, and other valuable, supplemental pieces.

Includes indexes.

The proceedings, International Workshop on Ship and Platform Motions, October 26-28, 1983 /

National Science Foundation Grant no. MEA-8310520 and Office of Naval Research Grant no. N00014-83-G-0066.

Les clubs et les clubistes; histoire complète critique et anecdotique des clubs et des comités électoraux fondés à Paris depuis la revolution de 1848: déclarations de principes, règlements, motions et publications des sociétés populaires. Détails inédits sur les principaux clubistes, sur l'esprit, les tendances et les actes des réunions dont ils faisaient partie, etc., etc.

Mode of access: Internet.

The student's assistant in astronomy and astrology : containing observations on the real and apparent motions of the superior planets, the geocentric longitude of the sun and superior planets ... also a discourse on the harmony of phrenology, astrology, and physiognomy /

Mode of access: Internet.

The trial of Aaron Burr for high treason, in the Circuit Court of the United States for the district of Virginia, summer term, 1807 : comprising all the evidence and the opinions of the court upon all motions made in the various stages of the case, with abstracts of arguments of counsel : compiled from authentic reports made during the progess of the trial : to which is added an account of the subsequent proceedings against Burr, Blennerhassett, and Smith, in the same court, with notes by the compiler on the law of treason, as applicable to the existing rebellion : prefaced by a brief historical sketch of Burr's western expedition of 1806 /

Mode of access: Internet.

Interlocutory motions in the United States Patent office; notes to rules 96-97, 109, 122, 123, 130, and 153.

Advertising matter: p. [162]-165

Determination of Biomolecular Interdomain Motions using Nuclear Magnetic Resonance

Biological macromolecules can rearrange interdomain orientations when binding to various partners. Interdomain dynamics serve as a molecular mechanism to guide the transitions between orientations. However, our understanding of interdomain dynamics is limited because a useful description of interdomain motions requires an estimate of the probabilities of interdomain conformations, increasing complexity of the problem.

Staphylococcal protein A (SpA) has five tandem protein-binding domains and four interdomain linkers. The domains enable Staphylococcus aureus to evade the host immune system by binding to multiple host proteins including antibodies. Here, I present a study of the interdomain motions of two adjacent domains in SpA. NMR spin relaxation experiments identified a 6-residue flexible interdomain linker and interdomain motions. To quantify the anisotropy of the distribution of interdomain orientations, we measured residual dipolar couplings (RDCs) from the two domains with multiple alignments. The N-terminal domain was directly aligned by a lanthanide ion and not influenced by interdomain motions, so it acted as a reference frame to achieve motional decoupling. We also applied {\it de novo} methods to extract spatial dynamic information from RDCs and represent interdomain motions as a continuous distribution on the 3D rotational space. Significant anisotropy was observed in the distribution, indicating the motion populates some interdomain orientations more than others. Statistical thermodynamic analysis of the observed orientational distribution suggests that it is among the energetically most favorable orientational distributions for binding to antibodies. Thus, the affinity is enhanced by a pre-posed distribution of interdomain orientations while maintaining the flexibility required for function.

The protocol described above can be applied to other biological systems in general. Protein molecule calmodulin and RNA molecule trans-activation response element (TAR) also have intensive interdomain motions with relative small intradomain dynamics. Their interdomain motions were studied using our method based on published RDC data. Our results were consistent with literature results in general. The differences could be due to previous studies' use of physical models, which contain assumptions about potential energy and thus introduced non-experimental information into the interpretations.

A Putative Otu Domain-containing Protein 1 Deubiquitinating Enzyme Is Differentially Expressed In Thyroid Cancer And Identifies Less-aggressive Tumours.

This study aimed to identify novel biomarkers for thyroid carcinoma diagnosis and prognosis. We have constructed a human single-chain variable fragment (scFv) antibody library that was selected against tumour thyroid cells using the BRASIL method (biopanning and rapid analysis of selective interactive ligands) and phage display technology. One highly reactive clone, scFv-C1, with specific binding to papillary thyroid tumour proteins was confirmed by ELISA, which was further tested against a tissue microarray that comprised of 229 thyroid tissues, including: 110 carcinomas (38 papillary thyroid carcinomas (PTCs), 42 follicular carcinomas, 30 follicular variants of PTC), 18 normal thyroid tissues, 49 nodular goitres (NG) and 52 follicular adenomas. The scFv-C1 was able to distinguish carcinomas from benign lesions (P=0.0001) and reacted preferentially against T1 and T2 tumour stages (P=0.0108). We have further identified an OTU domain-containing protein 1, DUBA-7 deubiquitinating enzyme as the scFv-binding antigen using two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. The strategy of screening and identifying a cell-surface-binding antibody against thyroid tissues was highly effective and resulted in a useful biomarker that recognises malignancy among thyroid nodules and may help identify lower-risk cases that can benefit from less-aggressive management.

Applications Of Visual Evoked Potentials And Fourier-domain Optical Coherence Tomography In Parkinson's Disease: A Controlled Study.

The goal of this cross-sectional observational study was to quantify the pattern-shift visual evoked potentials (VEP) and the thickness as well as the volume of retinal layers using optical coherence tomography (OCT) across a cohort of Parkinson's disease (PD) patients and age-matched controls. Forty-three PD patients and 38 controls were enrolled. All participants underwent a detailed neurological and ophthalmologic evaluation. Idiopathic PD cases were included. Cases with glaucoma or increased intra-ocular pressure were excluded. Patients were assessed by VEP and high-resolution Fourier-domain OCT, which quantified the inner and outer thicknesses of the retinal layers. VEP latencies and the thicknesses of the retinal layers were the main outcome measures. The mean age, with standard deviation (SD), of the PD patients and controls were 63.1 (7.5) and 62.4 (7.2) years, respectively. The patients were predominantly in the initial Hoehn-Yahr (HY) disease stages (34.8% in stage 1 or 1.5, and 55.8 % in stage 2). The VEP latencies and the thicknesses as well as the volumes of the retinal inner and outer layers of the groups were similar. A negative correlation between the retinal thickness and the age was noted in both groups. The thickness of the retinal nerve fibre layer (RNFL) was 102.7 μm in PD patients vs. 104.2 μm in controls. The thicknesses of retinal layers, VEP, and RNFL of PD patients were similar to those of the controls. Despite the use of a representative cohort of PD patients and high-resolution OCT in this study, further studies are required to establish the validity of using OCT and VEP measurements as the anatomic and functional biomarkers for the evaluation of retinal and visual pathways in PD patients.