Effect of addition of pigments and opacifier on the hardness, absorption, solubility and surface degradation of facial silicone after artificial ageing

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Maxillo-mandibular counter-clockwise rotation and mandibular advancement with TMJ Concepts (R) total joint prostheses Part III - Pain and dysfunction outcomes

47 end-stage TMJ patients with high occlusal plane angulation, treated with TMJ custom-fitted total joint prostheses and simultaneous maxillo-mandibular counter-clockwise rotation were evaluated for pain and dysfunction presurgery (T1) and at the longest follow-up (T2). Patients subjectively rated their facial pain/headache, TMJ pain, jaw function, diet and disability. Objective functional changes were determined by measuring maximum interincisal opening (MIO) and laterotrusive movements. Patients were divided according to the number of previous failed TMJ surgeries: Group 1 (0-1), Group 2 (2 or more). Significant subjective pain and dysfunction improvements (37-52%) were observed (<0.001). MIO increased 14% but lateral excursion decreased 60%. The groups presented similar absolute changes, but Group 2 showed more dysfunction at T1 and T2. For patients who did not receive fat grafts around the prostheses and had previous failure of proplast/teflon and or silastic TMJ implants, more than half required surgery for TMJ debridement and removal of foreign body giant cell reaction and heterotopic bone formation. End-stage TMJ patients can be treated in one operation with TMJ custom-made total joint prostheses and maxillo-mandibular counter-clockwise rotation, for correction of dentofacial deformity and improvement in pain and TMJ dysfunction; Group 1 patients had better results than Group 2 patients.

Avaliação dos contatos oclusais em próteses provisórias unitárias implantossuportadas confeccionadas com e sem arco facial

To assess the number of occlusal contacts achieved in temporal prostheses mounted in a semi-adjusted articulator using the facial arch and the Camper plane. Ten patients treated in a private clinic were selected to be rehabilitated with prostheses in previously placed single implants. For each patient two temporal prostheses were designed obtained under different conditions: (1) model mounting using facial arch and (2) Camper plane mounting. Prostheses were made and adjusted in the laboratory and placed only by an operator. The occlusal contacts achieved in each condition were photographed being assessed and quantified by a second professional not involved with the mounting conditions. Results obtained were analyzed by Mann-Whitney test with a 5 % significance level. There was not a statistically difference between the number of occlusal contacts when prostheses were made with facial arch or Camper plane (p= 0.113). The temporal dental prosthesis confection for single implants, semi-adjusted articulator using the Camper plane, not differ very much from the facial arch use, according to the number of resulting occlusal contacts.

An alternate impression technique for ocular prostheses

This article describes an alternative two-step ocular prosthesis impression technique that employs two materials of different consistencies. The method is intended to provide better adaptation to underlying tissues, increased mobility of the prosthesis owing to improvements in facial contours, and improved esthetics, as well as offering the patient greater comfort and security. These advantages and this prosthesis' relative ease of fabrication mean it should be considered as the first step in the management of untreated anophthalmic sockets. © 2012 by the American College of Prosthodontists.

Influência da adição de nanopartículas sobre a dureza, resistência à ruptura e deformação permanente de silicone facial submetido ao envelhecimento acelerado

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Bonding of facial silicon with nanoparticles to an acrylic resin substrate

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

O impacto das próteses implantosuportadas na harmonia facial

Many patients seeking dental care wish to improve facial and smile aesthetics to be accepted in modern day society. In denture wearers, the physiological resorption causes atrophy mainly in the maxilla, being necessary to carry out reconstruction techniques and sometimes orthognathic surgery to improve occlusal stability and facial harmony. The aim of this study is to discuss the features related to the rehabilitation of edentulous patients with indication for reconstruction of the maxilla using bone grafts and orthognathic surgery by means of a clinical case. In the present case, after the prosthetic rehabilitation, the patient was full satisfied with obtained results and dismissed the initially proposed surgical protocol. Therefore, professionals should provide therapeutic options but the patient’s opinion should prevail provided its clinical feasibility.

Fabrication techniques for ocular prostheses: an overview

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

O impacto das próteses implantossuportadas na harmonia facial

Many patients seeking dental care wish to improve facial and smile aesthetics to be accepted in modern day society. In denture wearers, the physiological resorption causes atrophy mainly in the maxilla, being necessary to carry out reconstruction techniques and sometimes orthognathic surgery to improve occlusal stability and facial harmony. The aim of this study is to discuss the features related to the rehabilitation of edentulous patients with indication for reconstruction of the maxilla using bone grafts and orthognathic surgery by means of a clinical case. In the present case, after the prosthetic rehabilitation, the patient was full satisfied with obtained results and dismissed the initially proposed surgical protocol. Therefore, professionals should provide therapeutic options but the patient’s opinion should prevail provided its clinical feasibility.

BMP-SIGNALING REGULATES A COMMON TRANSCRIPTIONAL PROGRAM TO CONTROL FACIAL FORM AND SKELETAL MORPHOGENESIS

Much of the craniofacial skeleton, such as the skull vault, mandible and midface, develops through direct, intramembranous ossification of the cranial neural crest (CNC) derived progenitor cells. Bmp-signaling plays critical roles in normal craniofacial development, and Bmp4 deficiency results in craniofacial abnormalities, such as cleft lip and palate. We performed an in depth analysis of Bmp4, a critical regulator of development, disease, and evolution, in the CNC. Conditional Bmp4 overexpression, using a tetracycline regulated Bmp4 gain of function allele, resulted in facial form changes that were most dramatic after an E10.5 Bmp4 induction. Expression profiling uncovered a signature of Bmp4 induced genes (BIG) composed predominantly of transcriptional regulators controlling self-renewal, osteoblast differentiation, and negative Bmp autoregulation. The complimentary experiment, CNC inactivation of Bmp2, Bmp4, and Bmp7, resulted in complete or partial loss of multiple CNC derived skeletal elements revealing a critical requirement for Bmp-signaling in membranous bone and cartilage development. Importantly, the BIG signature was reduced in Bmp loss of function mutants indicating similar Bmp-regulated target genes underlying facial form modulation and normal skeletal morphogenesis. Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG signature, including Satb2, Smad6, Hand1, Gadd45g and Gata3 that was bound by Smad1/5 in the developing mandible revealing direct, Smad-mediated regulation. These data indicate that Bmp-signaling regulates craniofacial skeletal development and facial form by balancing self-renewal and differentiation pathways in CNC progenitors.

Desarrollo de un sistema de reconocimiento facial

El objetivo principal alrededor del cual se desenvuelve este proyecto es el desarrollo de un sistema de reconocimiento facial. Entre sus objetivos específicos se encuentran: realizar una primera aproximación sobre las técnicas de reconocimiento facial existentes en la actualidad, elegir una aplicación donde pueda ser útil el reconocimiento facial, diseñar y desarrollar un programa en MATLAB que lleve a cabo la función de reconocimiento facial, y evaluar el funcionamiento del sistema desarrollado. Este documento se encuentra dividido en cuatro partes: INTRODUCCIÓN, MARCO TEÓRICO, IMPLEMENTACIÓN, y RESULTADOS, CONCLUSIONES Y LÍNEAS FUTURAS. En la primera parte, se hace una introducción relativa a la actualidad del reconocimiento facial y se comenta brevemente sobre las técnicas existentes para desarrollar un sistema biométrico de este tipo. En ella se justifican también aquellas técnicas que acabaron formando parte de la implementación. En la segunda parte, el marco teórico, se explica la estructura general que tiene un sistema de reconocimiento biométrico, así como sus modos de funcionamiento, y las tasas de error utilizadas para evaluar y comparar su rendimiento. Así mismo, se lleva a cabo una descripción más profunda sobre los conceptos y métodos utilizados para efectuar la detección y reconocimiento facial en la tercera parte del proyecto. La tercera parte abarca una descripción detallada de la solución propuesta. En ella se explica el diseño, características y aplicación de la implementación; que trata de un programa elaborado en MATLAB con interfaz gráfica, y que utiliza cuatro sistemas de reconocimiento facial, basados cada uno en diferentes técnicas: Análisis por componentes principales, análisis lineal discriminante, wavelets de Gabor, y emparejamiento de grafos elásticos. El programa ofrece además la capacidad de crear y editar una propia base de datos con etiquetas, dándole aplicación directa sobre el tema que se trata. Se proponen además una serie de características con el objetivo de ampliar y mejorar las funcionalidades del programa diseñado. Dentro de dichas características destaca la propuesta de un modo de verificación híbrido aplicable a cualquier rama de la biometría y un programa de evaluación capaz de medir, graficar, y comparar las configuraciones de cada uno de los sistemas de reconocimiento implementados. Otra característica destacable es la herramienta programada para la creación de grafos personalizados y generación de modelos, aplicable a reconocimiento de objetos en general. En la cuarta y última parte, se presentan al principio los resultados obtenidos. En ellos se contemplan y analizan las comparaciones entre las distintas configuraciones de los sistemas de reconocimiento implementados para diferentes bases de datos (una de ellas formada con imágenes con condiciones de adquisición no controladas). También se miden las tasas de error del modo de verificación híbrido propuesto. Finalmente, se extraen conclusiones, y se proponen líneas futuras de investigación. ABSTRACT The main goal of this project is to develop a facial recognition system. To meet this end, it was necessary to accomplish a series of specific objectives, which were: researching on the existing face recognition technics nowadays, choosing an application where face recognition might be useful, design and develop a face recognition system using MATLAB, and measure the performance of the implemented system. This document is divided into four parts: INTRODUCTION, THEORTICAL FRAMEWORK, IMPLEMENTATION, and RESULTS, CONCLUSSIONS AND FUTURE RESEARCH STUDIES. In the first part, an introduction is made in relation to facial recognition nowadays, and the techniques used to develop a biometric system of this kind. Furthermore, the techniques chosen to be part of the implementation are justified. In the second part, the general structure and the two basic modes of a biometric system are explained. The error rates used to evaluate and compare the performance of a biometric system are explained as well. Moreover, a description of the concepts and methods used to detect and recognize faces in the third part is made. The design, characteristics, and applications of the systems put into practice are explained in the third part. The implementation consists in developing a program with graphical user interface made in MATLAB. This program uses four face recognition systems, each of them based on a different technique: Principal Component Analysis (PCA), Fisher’s Linear Discriminant (FLD), Gabor wavelets, and Elastic Graph Matching (EGM). In addition, with this implementation it is possible to create and edit one´s tagged database, giving it a direct application. Also, a group of characteristics are proposed to enhance the functionalities of the program designed. Among these characteristics, three of them should be emphasized in this summary: A proposal of an hybrid verification mode of a biometric system; and an evaluation program capable of measuring, plotting curves, and comparing different configurations of each implemented recognition system; and a tool programmed to create personalized graphs and models (tagged graph associated to an image of a person), which can be used generally in object recognition. In the fourth and last part of the project, the results of the comparisons between different configurations of the systems implemented are shown for three databases (One of them created with pictures taken under non-controlled environments). The error rates of the proposed hybrid verification mode are measured as well. Finally, conclusions are extracted and future research studies are proposed.

Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo

The ciliary neurotrophic factor alpha-receptor(CNTFRalpha) is required for motoneuron survival during development, but the relevant ligand(s) has not been determined. One candidate is the heterodimer formed by cardiotrophin-like cytokine (CLC) and cytokine-like factor 1 (CLF). CLC/CLF binds to CNTFRalpha and enhances the survival of developing motoneurons in vitro; whether this novel trophic factor plays a role in neural development in vivo has not been tested. We examined motor and sensory neurons in embryonic chicks treated with CLC and in mice with a targeted deletion of the clf gene. Treatment with CLC increased the number of lumbar spinal cord motoneurons that survived the cell death period in chicks. However, this effect was regionally specific, because brachial and thoracic motoneurons were unaffected. Similarly, newborn clf -/- mice exhibited a significant reduction in lumbar motoneurons, with no change in the brachial or thoracic cord. Clf deletion also affected brainstem motor nuclei in a regionally specific manner; the number of motoneurons in the facial but not hypoglossal nucleus was significantly reduced. Sensory neurons of the dorsal root ganglia were not affected by either CLC treatment or clf gene deletion. Finally, mRNA for both clc and clf was found in skeletal muscle fibers of embryonic mice during the motoneuron cell death period. These findings support the view that CLC/CLF is a target-derived factor required for the survival of specific pools of motoneurons. The in vivo actions of CLC and CLF can account for many of the effects of CNTFRalpha on developing motoneurons.

Identification and analysis of novel genes expressed in the mouse embryonic facial primordia

Craniofacial anomalies are a common feature of human congenital dysmorphology syndromes, suggesting that genes expressed in the developing face are likely to play a wider role in embryonic development. To facilitate the identification of genes involved in embryogenesis, we previously constructed an enriched cDNA library by subtracting adult mouse liver cDNA from that of embryonic day (E)10.5 mouse pharyngeal arch cDNA. From this library, 273 unique clones were sequenced and known proteins binned into functional categories in order to assess enrichment of the library (1). We have now selected 31 novel and poorly characterised genes from this library and present bioinformatic analysis to predict proteins encoded by these genes, and to detect evolutionary conservation. Of these genes 61% (19/31) showed restricted expression in the developing embryo, and a subset of these was chosen for further in silico characterisation as well as experimental determination of subcellular localisation based on transient transfection of predicted full-length coding sequences into mammalian cell lines. Where a human orthologue of these genes was detected, chromosomal localisation was determined relative to known loci for human congenital disease.

Computational methods for the detection of facial palsy

We are developing a telemedicine application which offers automated diagnosis of facial (Bell's) palsy through a Web service. We used a test data set of 43 images of facial palsy patients and 44 normal people to develop the automatic recognition algorithm. Three different image pre-processing methods were used. Machine learning techniques (support vector machine, SVM) were used to examine the difference between the two halves of the face. If there was a sufficient difference, then the SVM recognized facial palsy. Otherwise, if the halves were roughly symmetrical, the SVM classified the image as normal. It was found that the facial palsy images had a greater Hamming Distance than the normal images, indicating greater asymmetry. The median distance in the normal group was 331 (interquartile range 277-435) and the median distance in the facial palsy group was 509 (interquartile range 334-703). This difference was significant (P

Producing facial composite sketches in remote cognitive interviews:a preliminary investigation

Justice systems around the world are increasingly turning to videoconferencing as a means to reduce delays and reduce costs in legal processes. This preliminary research examined whether interviewing a witness remotely - without physical co-presence of the witness and interviewer - could facilitate the production of quality facial composite sketches of suspects. In Study 1, 42 adults briefly viewed a photograph of a face. The next day they participated in Cognitive Interviews with a forensic artist, conducted either face-to-face or remotely via videoconference. In Study 2, 20 adults participated in videoconferenced interviews, and we manipulated the method by which they viewed the developing sketch. In both studies, independent groups of volunteers rated the likeness of the composites to the original photographs. The data suggest that remote interviews elicited effective composites; however, in Study 1 these composites were considered poorer matches to the photographs than were those produced in face-to-face interviews. The differences were small, but significant. Participants perceived several disadvantages to remote interviewing, but also several advantages including less pressure and better concentration. The results of Study 2 suggested that different sketch presentation methods offered different benefits. We propose that remote interviewing could be a useful tool for investigators in certain circumstances. © 2013 Taylor & Francis.