A monograph on the antique cameo : the triumph of Constantine, formerly in the cabinet of Catherine II, of Russia /

Mode of access: Internet.

Public laws of the state of Rhode-Island and Providence plantations, as revised by a committee, and finally enacted by the General assembly at the session in January, 1844. To which are prefixed, the Charter of Charles II., Declaration of independence, resolution of General assembly to support the Declaration of independence, resolution of General assembly to support the Declaration of independence, Articles of confederation, Constitution of the United States, proceedings of the Convention on the adoption of the Constitution of the United States by Rhode-Island, President Washington's address of September, 1796, and constitution of the state of Rhode-Island and Providence plantations.

Mode of access: Internet.

Paul the First of Russia, the son of Catherine the Great,

Mode of access: Internet.

Randomized Phase II trial of nintedanib, afatinib and sequential combination in castration-resistant prostate cancer

AIMS: The aim of this article was to evaluate afatinib (BIBW 2992), an ErbB family blocker, and nintedanib (BIBF 1120), a triple angiokinase inhibitor, in castration-resistant prostate cancer patients.

PATIENTS & METHODS: Patients were randomized to receive nintedanib (250 mg twice daily), afatinib (40 mg once daily [q.d.]), or alternating sequential 7-day nintedanib (250 mg twice daily) and afatinib (70 mg q.d. [Combi70]), which was reduced to 40 mg q.d. (Combi40) due to adverse events. The primary end point was progression-free rate at 12 weeks.

RESULTS: Of the 85 patients treated 46, 20, 16 and three received nintedanib, afatinib, Combi40 and Combi70, respectively. At 12 weeks, the progression-free rate was 26% (seven out of 27 patients) for nintedanib, and 0% for afatinib and Combi40 groups. Two patients had a ≥50% decline in PSA (nintedanib and the Combi40 groups). The most common drug-related adverse events were diarrhea, nausea, vomiting and lethargy.

CONCLUSION: Nintedanib and/or afatinib demonstrated limited anti-tumor activity in unselected advanced castration-resistant prostate cancer patients.

Genetic Manipulation of Condensed Tannins in Higher Plants1 : II. Analysis of Birdsfoot Trefoil Plants Harboring Antisense Dihydroflavonol Reductase Constructs

We have produced and analyzed transgenic birdsfoot trefoil (Lotus corniculatus L.) plants harboring antisense dihydroflavonol reductase (AS-DFR) sequences. In initial experiments the effect of introducing three different antisense Antirrhinum majus L. DFR constructs into a single recipient genotype (S50) was assessed. There were no obvious effects on plant biomass, but levels of condensed tannins showed a statistical reduction in leaf, stem, and root tissues of some of the antisense lines. Transformation events were also found, which resulted in increased levels of condensed tannins. In subsequent experiments a detailed study of AS-DFR phenotypes was carried out in genotype S33 using pMAJ2 (an antisense construct comprising the 5′ half of the A. majus cDNA). In this case, reduced tannin levels were found in leaf and stem tissues and in juvenile shoot tissues. Analysis of soluble flavonoids and isoflavonoids in tannin down-regulated shoot tissues indicated few obvious default products. When two S33 AS-DFR lines were outcrossed, there was an underrepresentation of transgene sequences in progeny plants and no examples of inheritance of an antisense phenotype were observed. To our knowledge, this is the first report of the genetic manipulation of condensed tannin biosynthesis in higher plants.

Vie de Catherine II, Impératrice de Russie ... : tome premier.

Mode of access: Internet.

Vie de Catherine II Impératrice de Russie ... : tome second.

Mode of access: Internet.

Les plans et les statuts, des différents établissements ordonnés par sa Majésté Impériale Catherine II, pour l'éducation de la jeunesse et l'utilité générale de son empire /

Mode of access: Internet.

Les plans et les statuts, des différents établissements ordonnés par sa Majésté Impériale Catherine II, pour l'éducation de la jeunesse et l'utilité générale de son empire /

Mode of access: Internet.

Oeuvres mathématiques de Jean Dolbnia, publiées sous les auspices de l'École supérieure des mines de l'impératrice Catherine II à St.-Pétersbourg;

"Liste des mémoires de Jean Dolbnia publiés en langue russe et qui ne sont pas contenus dans la présente édition": p. [xiii]-xiv.

Les épistoliers du XVIIIe siècle: Mme de Staal--Président de Brosses--Voltaire--Mirabeau--Mme du Deffand--Mlle de Lespinasse--Mme d'Epinay--Frédéric II--Mme Roland--Catherine II--Le prince de Ligne; extraits.

Includes bibliographical references.

Œuvres mathématiques de Jean Dolbnia, publiées sous les auspices de l'École supérieure des mines de l'impératrice catherine II à St.-Pétersbourg;

Available on demand as hard copy or computer file from Cornell University Library.

Posthumous works of Frederic II, King of Prussia.

"Translated from the French by Thomas Holcroft."

Recollections of a Russian diplomat; the suicide of monarchies (William II and Nicholas II)

Preface signed: L. W. Makovski.