Mejoramiento del ambiente comp. [por] R. H. García Cázares

UANL

Ciencias sociales primer curso comp. [por] S. Iglesias

UANL

Uno de tantos crímenes antología de cuentos comp. [por] Yuri Vladimir Delgado Santos

UANL

Catecismo de la Sagrada Biblia estractado de varios autores y casi literalmente del Diccionario Teológico del Abate Bergier; comp. por José Mariano Galíndez

UANL

Introduction to Professional Issues COMP 1205

Explains how this module is organised, and the motivation

Movimientos sociales y autonomía colectiva. La política de la esperanza en América Latina, de Dinerstein, A. C. (comp.)

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Paco de Luc??a y otros al comp??s

Resumen basado en el de la publicaci??n

Ribozyme-mediated reduction of wild-type and mutant cartilage oligomeric matrix protein (COMP) mRNA and protein.

Dominant-negative mutations in the homopentameric extracellular matrix glycoprotein cartilage oligomeric matrix protein (COMP) result in inappropriate intracellular retention of misfolded COMP in the rough endoplasmic reticulum of chondrocytes, causing chondrocyte cell death, which leads to two skeletal dysplasias: pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1). COMP null mice show no adverse effects on normal bone development and growth, suggesting a possible therapy involving removal of COMP mRNA. The goal of this study was to assess the ability of a hammerhead ribozyme (Ribo56, designed against the D469del mutation) to reduce COMP mRNA expression. In COS7 cells transfected with plasmids that overexpress wild-type or mutant COMP mRNA and Ribo56, the ribozyme reduced overexpressed normal COMP mRNA by 46% and mutant COMP mRNA by 56% in a dose-dependent manner. Surprisingly, the use of recombinant adenoviruses to deliver wild-type or mutant COMP mRNA and Ribo56 simultaneously into COS7 cells proved problematic for the activity of the ribozyme to reduce COMP expression. However, in normal human costochondral cells (hCCCs) infected only with adenoviruses expressing Ribo56, expression of endogenous wild-type COMP mRNA was reduced in a dose-dependent manner by 50%. In chondrocytes that contain heterozygous COMP mutations (D469del, G427E and D511Y) that cause PSACH, Ribo56 was more effective at reducing COMP mRNA (up to 70%). These results indicate that Ribo56 is effective at reducing mutant and wild-type COMP levels in cells and suggests a possible mode of therapy to reduce the mutant protein load.

Characterization of dermatan sulfate proteoglycan 3 (DSPG3) and cartilage oligomeric matrix protein (COMP)

This dissertation describes the identification and characterization of human dermatan sulfate proteoglycan 3 (DSPG3) and the characterization of the transcriptional regulation of human cartilage oligomeric matrix protein (COMP) in cartilage, ligament, and tendon cells. DSPG3 and COMP are two extracellular matrix proteins. The function of these ECM proteins is unknown.^ DSPG3 was cloned, sequenced, and shown to be expressed in cartilage, ligament, and placenta. DSPG3 was mapped to human chromosome 12q21, and the genomic structure was identified. 1.6 kb of the promoter region has been sequenced, and several putative SOX9 sites were identified as well as 3 TATA sites. Furthermore, an evolutionary tree of the SLRP gene family, which includes DSPG3, is presented.^ The promoter region of COMP was cloned and sequenced. Several putative transcription factor binding sites were identified including multiple AP2 and SP1 sites. Three transcription start sites were found to be located directly downstream of one of the SP1 sites. In addition, the expression of COMP was demonstrated to be higher in tendon than in cartilage and ligament by both Northern and Western blot analysis, and several regions of the COMP promoter were shown to contain cell-specific regulatory elements. Analysis of the proximal 370bp region of the COMP promoter has also identified distinct patterns of nuclear protein binding for the three tissues, and two SP1 sites may play a role in the tissue-specific expression of COMP. ^

5 israelitische Tempelcompositionen für den Sabbath : comp für Chor u. Solo

von A. Dunajewsky

Fragm. lat. III 6 - Notula ad Compilationem III iuris canonici (Comp. III 1.3.7/1.4.1)

Trägerband: Ms. Barth. 28; Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Fernández Nadal, Estela (comp). Itinerarios socialistas en América Latina. Córdoba, Alción, 2001, 230 páginas.

Fil: Molina, Mercedes. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociales

Picotti, Dina V. (comp.). El negro en Argentina : presencia y negación. Buenos Aires, Editores de América Latina, 2001, 513 p.

Fil: Picotti, Dina V..

Quiroga, Hugo; Villavicencio, Susana; Vermeren, Patrice (comp.). Filosofías de la ciudadanía. Sujeto político y democracia. Rosario (Argentina), Homo Sapiens Ediciones, 1999, 260p.

Fil: Muñoz, Marisa Alejandra.