[Lettre autographe signée d'Henri Montan Berton, 25 mars 1838]

Destinataire non identifié

[Lettre autographe signée d'Henri Montan Berton aux Académiciens, Paris, 17 mars 1838]

Communication à l'Académie : "proposition tendant à améliorer le sort des élèves musiciens à leur retour de Rome dans la capitale". - Signé : Berton, Halévy, Paer, Meyerbeer, Carafa, Cherubini

Polyphyly of the hawk genera Leucopternis and Buteogallus (Aves, Accipitridae): multiple habitat shifts during the Neotropical buteonine diversification

Abstract Background The family Accipitridae (hawks, eagles and Old World vultures) represents a large radiation of predatory birds with an almost global distribution, although most species of this family occur in the Neotropics. Despite great morphological and ecological diversity, the evolutionary relationships in the family have been poorly explored at all taxonomic levels. Using sequences from four mitochondrial genes (12S, ATP8, ATP6, and ND6), we reconstructed the phylogeny of the Neotropical forest hawk genus Leucopternis and most of the allied genera of Neotropical buteonines. Our goals were to infer the evolutionary relationships among species of Leucopternis, estimate their relationships to other buteonine genera, evaluate the phylogenetic significance of the white and black plumage patterns common to most Leucopternis species, and assess general patterns of diversification of the group with respect to species' affiliations with Neotropical regions and habitats. Results Our molecular phylogeny for the genus Leucopternis and its allies disagrees sharply with traditional taxonomic arrangements for the group, and we present new hypotheses of relationships for a number of species. The mtDNA phylogenetic trees derived from analysis of the combined data posit a polyphyletic relationship among species of Leucopternis, Buteogallus and Buteo. Three highly supported clades containing Leucopternis species were recovered in our phylogenetic reconstructions. The first clade consisted of the sister pairs L. lacernulatus and Buteogallus meridionalis, and Buteogallus urubitinga and Harpyhaliaetus coronatus, in addition to L. schistaceus and L. plumbeus. The second clade included the sister pair Leucopternis albicollis and L. occidentalis as well as L. polionotus. The third lineage comprised the sister pair L. melanops and L. kuhli, in addition to L. semiplumbeus and Buteo buteo. According to our results, the white and black plumage patterns have evolved at least twice in the group. Furthermore, species found to the east and west of the Andes (cis-Andean and trans-Andean, respectively) are not reciprocally monophyletic, nor are forest and non-forest species. Conclusion The polyphyly of Leucopternis, Buteogallus and Buteo establishes a lack of concordance of current Accipitridae taxonomy with the mtDNA phylogeny for the group, and points to the need for further phylogenetic analysis at all taxonomic levels in the family as also suggested by other recent analyses. Habitat shifts, as well as cis- and trans-Andean disjunctions, took place more than once during buteonine diversification in the Neotropical region. Overemphasis of the black and white plumage patterns has led to questionable conclusions regarding the relationships of Leucopternis species, and suggests more generally that plumage characters should be used with considerable caution in the taxonomic evaluation of the Accipitridae.

Reversal of established lupus nephritis and prolonged survival of New Zealand black x New Zealand white mice treated with the topoisomerase I inhibitor irinotecan

Systemic lupus erythematosus is a chronic autoimmune disorder that predominantly affects women of childbearing age. Lupus-associated glomerulonephritis is a major cause of mortality in these patients. Current treatment protocols for systemic lupus erythematosus include cyclophosphamide, prednisolone, azathioprine, and mycophenolate mofetil. However, in mice none of these agents alone or in combination were shown to reverse established proteinuria. Using New Zealand Black x New Zealand White F1 mice, we report that administration of the topoisomerase I inhibitor irinotecan from week 13 completely prevented the onset of proteinuria and prolonged survival up to at least 90 wk without detectable side effects. Furthermore, application of irinotecan to mice with established lupus nephritis, as indicated by grade 3+ (> or =300 mg/dl) and grade 4+ (> or =2000 mg/dl) proteinuria and, according to a median age of 35 wk, resulted in remission rates of 75% and 55%, respectively. Survival was significantly prolonged with 73 wk (grade 3+ and 4+ combined) versus 40 wk for control animals. Although total IgG and anti-dsDNA Abs in the serum and mesangial IgG deposits in the kidneys were not reduced in irinotecan-treated mice, subendothelial immune deposits were considerably diminished, suggesting a prevention of glomerular basement membrane disruption. This effect was accompanied by increased rates of ssDNA breaks and inhibition of renal cell apoptosis being different to what is known about irinotecan in anticancer therapy. In conclusion, our data provide evidence that irinotecan might represent an entirely new strategy for the treatment of systemic lupus erythematosus.

Manuscript copy of the book of Harvard, 1767

The pamphlet-sized manuscript includes "The Book of Harvard" signed "Joseph Cummings, scriptis, Janr 7th 1767," an untitled two-page essay beginning, "Wisdom is ye Crown of life" and ending "Draught of Knowledge, let us with a laudable ambition, strive to excel each other in an ardent pursuit of Learning, then shall we raise to ourselves a monument of honest fame, which shall perish only in ye general wreak of nature," and on the last page, "An Accrostick" beginning "Jangling & Discord are thy Souls delight" and spelling out JAMES MITCHEL VARNUM dated July 3, 1767 and signed "The 3d edition revised & improved by Gove & Fogg."

Manuscript copy of the book of Harvard, 1767

Handwritten copy of the Book of Harvard written on one large sheet of paper and signed Boston, January 10th, 1767.

Lower Manhattan, New York, N.Y. 1767 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: To His Excellency Sr. Henry Moore, Bart., captain general and governour in chief in & over the province of New York & the territories depending thereon in America, chancellor & vice admiral of the same, this plan of the city of New York is most humbly inscribed, by His Excellency's most obedient servant, Bern'd Ratzen [sic], lieut't in the 60th Reg't ; T. Kitchin, sculp't. It was published ca. 1769. Scale [ca. 1:4,800]. Covers Manhattan below 14th St. and a portion of Brooklyn. "Survey'd in 1767." The image inside the map neatline is georeferenced to the surface of the earth and fit to the Universal Transverse Mercator (UTM) Zone 18N NAD83 projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, ground cover, city wards, selected public buildings and names of property owners, city wards, and more. Relief is shown by hachures and shading. Includes index of "References" and coat-of-arms. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Hikayat Raja Kulawandu : manuscript, 1838

Title from f. 1r.

Baḥr al-jawāhir : manuscript, 1767

بسم الله الرحمن الرحيم وبه ثقتي حمد العلام اجدي ذوي الافهام بتحقيق دقايق اللغات ... :Incipit

Commonplace book : manuscript, 1820-1841

Written in several hands, some in red and black. Texts nos. 1, 2, 3, 7, 8, 9 are in the hand of Abdullah bin Abdulkadir.

Hikayat Darma Taʻsia : manuscript, 1838

According to the colophon (f. 68r), copy completed in Dhū al-Ḥijjah 1253 [February 1838] in the hand of Muhammad Ali bin Abdul Latif Munsyi.

Letter from John Ross, the principal chief of the Cherokee nation, to a gentleman of Philadelphia [i.e. Job R. Tyson]

The letter is dated May 6, 1837; Prefatory remarks by Tyson (?) dated Dec. 26, 1837.

Memoirs of Andrew Jackson : late major general and commander in chief of the Southern division of the army of the United States /

Avery Classics (Offsite) copy: Seymour B. Durst Old York Library Collection, Avery Architectural & Fine Arts Library, Columbia University.

An account of the manufacture of the black tea, as now practised at Suddeya in Upper Assaam, by the Chinamen sent thither for that purpose. With some observations on the culture of the plant in China, and its growth in Assam /

Mode of access: Internet.