Ms. Barth. 139 - De actibus apostolorum

Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Cause-Specific Long-Term Mortality in Survivors of Childhood Cancer in Switzerland: A Population Based Study.

Survivors of childhood cancer have a higher mortality than the general population. We describe cause-specific long-term mortality in a population-based cohort of childhood cancer survivors. We included all children diagnosed with cancer in Switzerland (1976-2007) at age 0-14 years, who survived ≥5 years after diagnosis and followed survivors until December 31, 2012. We obtained causes of death (COD) from the Swiss mortality statistics and used data from the Swiss general population to calculate age-, calendar year- and sex-standardized mortality ratios (SMR), and absolute excess risks (AER) for different COD, by Poisson regression. We included 3'965 survivors and 49'704 person years at risk. Of these, 246 (6.2%) died, which was 11 times higher than expected (SMR 11.0). Mortality was particularly high for diseases of the respiratory (SMR 14.8) and circulatory system (SMR 12.7), and for second cancers (SMR 11.6). The pattern of cause-specific mortality differed by primary cancer diagnosis, and changed with time since diagnosis. In the first 10 years after 5-year survival, 78.9% of excess deaths were caused by recurrence of the original cancer (AER 46.1). Twenty-five years after diagnosis, only 36.5% (AER 9.1) were caused by recurrence, 21.3% by second cancers (AER 5.3) and 33.3% by circulatory diseases (AER 8.3). Our study confirms an elevated mortality in survivors of childhood cancer for at least 30 years after diagnosis with an increased proportion of deaths caused by late toxicities of the treatment. The results underline the importance of clinical follow-up continuing years after the end of treatment for childhood cancer. This article is protected by copyright. All rights reserved.

Is human herpesvirus 8 infection more common in men than in women? Systematic review and meta-analysis.

All forms of Kaposi sarcoma (KS) are more common in men than in women. It is unknown if this is due to a higher prevalence of human herpesvirus 8 (HHV-8), the underlying cause of KS, in men compared to women. We did a systematic review and meta-analysis to examine the association between HHV-8 seropositivity and gender in the general population. Studies in selected populations like for example, blood donors, hospital patients, and men who have sex with men were excluded. We searched Medline and Embase from January 1994 to February 2015. We included observational studies that recruited participants from the general population and reported HHV-8 seroprevalence for men and women or boys and girls. We used random-effects meta-analysis to pool odds ratios (OR) of the association between HHV-8 and gender. We used meta-regression to identify effect modifiers, including age, geographical region and type of HHV-8 antibody test. We included 22 studies, with 36,175 participants. Men from sub-Saharan Africa (SSA) (OR 1.21, 95% confidence interval [CI] 1.09-1.34), but not men from elsewhere (OR 0.94, 95% CI 0.83-1.06), were more likely to be HHV-8 seropositive than women (p value for interaction=0.010). There was no difference in HHV-8 seroprevalence between boys and girls from SSA (OR 0.90, 95% CI 0.72-1.13). The type of HHV-8 assay did not affect the overall results. A higher HHV-8 seroprevalence in men than women in SSA may partially explain why men have higher KS risk in this region. This article is protected by copyright. All rights reserved.

Record linkage to correct under-ascertainment of cancers in HIV cohorts: the Sinikithemba HIV clinic linkage project.

The surveillance of HIV-related cancers in South Africa is hampered by the lack of systematic collection of cancer diagnoses in HIV cohorts and the absence of HIV status in cancer registries. To improve cancer ascertainment and estimate cancer incidence, we linked records of adults (aged ≥ 16 years) on antiretroviral treatment (ART) enrolled at Sinikithemba HIV clinic, McCord Hospital in KwaZulu-Natal (KZN) with the cancer records of public laboratories in KZN province using probabilistic record linkage methods. We calculated incidence rates for all cancers, Kaposi sarcoma (KS), cervix, non-Hodgkin's lymphoma and non-AIDS defining cancers (NADCs) before and after inclusion of linkage-identified cancers with 95% confidence intervals (CI). A total of 8,721 records of HIV-positive patients were linked with 35,536 cancer records. Between 2004 and 2010 we identified 448 cancers, 82% (n=367) were recorded in the cancer registry only, 10% (n=43) in the HIV cohort only and 8% (n=38) both in the HIV cohort and the cancer registry. The overall cancer incidence rate in patients starting ART increased from 134 (95% CI 91-212) to 877 (95% CI 744-1,041) after inclusion of linkage-identified cancers. Incidence rates were highest for KS (432, 95% CI 341-555), followed by cervix (259, 95% CI 179-390) and NADCs (294, 95% CI 223-395) per 100,000 person-years. Ascertainment of cancer in HIV cohorts is incomplete, probabilistic record linkage is both feasible and essential for cancer ascertainment. This article is protected by copyright. All rights reserved.

Ms. Praed. 139 - [Sammelband in 10 Teilen: Konvolut aus Handschrift und Inkunabeln]

Vorbesitzer: Kartause St. Johannes Baptista in Zeelhem; Petrus Dorlandus; Dominikanerkloster Frankfurt am Main

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 139 - Kritik an einen Artikel über Schopenhauer in dem Frankfurter Conversions-Blatt

u.a.: Mangelnde Anerkennung Schopenhauers in Frankfurt; Anregung zur Aufnahme weiterer Bibelstellen in "Der Welt als Wille und Vorstellung"; Parerga und Paralipomena; Johann Karl Friedrich Rosenkranz;

Ms.Ff.F.Stoltze 3. 139 - Brief von Otto Hörth an Marie Stoltze

Stoltze, Erlenbad, Wilhelm Rieger

Ms. lat. oct. 139 - Gesta Treverorum

Vorbesitzer: St. Eucharius-Matthias in Trier; Johann von Fichard; Johann Karl von Fichard gen. Baur von Eysseneck; Cronstettenstift; Stadtarchiv Frankfurt am Main

Na 1 Nachlass Max Horkheimer, 673 - Forschungsprojekte über Antisemitismus, Vorurteil, Autorität: Einzeluntersuchungen (p. IX 139 - IX 140.1-14)

Assignements. Anweisungen zu Einzeluntersuchungen des Antisemitismus-Projekts, 1943 und ohne Datum, 15 Blatt; Zum 'Berkeley Projekt on Antisemitism', 1944-1946; Sitzungsprotokolle und Memoranden der 'Los Angeles Branch of the Berkeley Research Project on Social Discrimination', 19.03.1946 - 11.04.1946, Typoskript, 11 Blatt; Frenkel-Brunswik, Else: 1 Brief mit Unterschrift an Max Horkheimer, ohne Ort, 10.01.1944, 6 Blatt; Interview- und Testprotokolle, Typoskript, 33 Blatt; Horkheimer, Max: 1 Brief an Theodor W. Adorno, ohne Ort, 11.10.1945, 5 Blatt; "Traits of the Authoritatian Character", a) Typoskript, 2 Blatt; b) Typoskript, 2 Blatt; c) Typoskript mit eigenhändigen Korrekturen und Ergänzungen, von Max Horkheimer, 2 Blatt; "Hypothese concerning indirect questions of Berkeley Questionaire". Als Typoskript vervielfältigt, 4 Blatt; Frenkel-Brunswik, Else; Sanford, R. Nevitt: "Some Personality Factors in Anti-Semitism", Sonderdruck aus: The Journal of Psychology, 1945, 20, S. 271-291; Levison, Daniel J.; Sanford, R. Nevitt: "A Scale for the Measurement of Anti-Semitism", Sonderdrucke aus: The Journal of Psychology, 1944,17, S.339-370; "'Unconscious' Facism", Excerpt aus: Propaganda Analysis, No. 7, L938, Typoskript 1 Blatt; Löwenthal, Leo: 1 Brief mit Unterschrift an Max Horkheimer, New York, 31.05.1945; Deutsch, Monroe E.: 2 Briefe mit Unterschrift an Max Horkheimer, Berkeley, 1945; 4 Briefe und Beantwortung von Max Horkheimer, Pacific Palisades, 1945; Lundberg, O.: 5 Briefe von Max Horkheimer, Pacific Palisades, 1945-1946; Sanfort, Nevitt: 1 Brief von Samuel H. Flowerman, ohne Ort, 14.06.1947; Statement for Berkeley Public Opinio Study Group Accounts, 19 Blatt;