Na 1 Nachlass Max Horkheimer, 515 - Korrespondenzen mit Theodor W. Adorno (p. VI 4, 215 - 355)

150 Briefe zwischen Theodor W. Adorno und Gretel Adorno und Max Horkheimer; 1 Brief (Abschrift, Kopie) von Ernst Bloch an Theodor W. Adorno, 14.09.1963; 1 Brief von Leo Löwenthal an Theodor W. Adorno, 06.09.1963; 1 Brief von Theodor W. Adorno an Leo Löwenthal, 18.11.1965; 1 Brief von Ilse Völker and Theodor W. Adorno, 14.06.1963; 1 Brief von Ulrich Beyer an Max Horkeimer, 15.04.1963; 1 Brief von Ulrich Beyer an Dr. Lepsius, 15.04.1963; 1 Brief von Alice Maier an Theodor W. Adorno, 14.02.1963; 2 Briefe von Theodor W. Adorno an Alice Maier, 1963 - 1964; 1 Brief von Felix Weil an Theodor W. Adorno, 11.04.1963; 1 Brief von Regina Pelzer an Theodor W. Adorno, [1963]; 1 Brief von Theodor W. Adorno an Schröder, [1963]; 1 Brief von der Europäischen Verlagsanstalt an Theodor W. Adorno, 17.11.1964; 1 Brief von Ruth Nanda Ashen an Theodor W. Adorno, 21.09.1964;

Ms.Ff.F.Stoltze 3. 355 - Brief von Friedrich Stoltze an Ludwig Knopf

Friedhof, Denkmal für die September-Gefallenen, Eduard Fay, Angebot der Reinigung und Unterhaltung

Safety, pharmacokinetics, and antiretroviral activity of multiple doses of ibalizumab (formerly TNX-355), an anti-CD4 monoclonal antibody in HIV-1 infected adults

Context: Despite tremendous strides in HIV treatment over the past decade, resistance remains a major problem. A growing number of patients develop resistance and require new therapies to suppress viral replication. ^ Objective: To assess the safety of multiple administrations of the anti-CD4 receptor (anti-CD4) monoclonal antibody ibalizumab given as intravenous (IV) infusions, in three dosage regimens, in subjects infected with human immunodeficiency virus (HIV-1). ^ Design: Phase 1, multi-center, open-label, randomized clinical trial comparing the safety, pharmacokinetics and antiviral activity of three dosages of ibalizumab. ^ Setting: Six clinical trial sites in the United States. ^ Participants: A total of twenty-two HIV-positive patients on no anti-retroviral therapy or a stable failing regimen. ^ Intervention: Randomized to one of two treatment groups in Arms A and B followed by non-randomized enrollment in Arm C. Patients randomized to Arm A received 10 mg/kg of ibalizumab every 7 days, for a total of 10 doses; patients randomized to Arm B received a total of six doses of ibalizumab; a single loading dose of 10 mg/kg on Day 1 followed by five maintenance doses of 6 mg/kg every 14 days, starting at Week 1. Patients assigned to Arm C received 25 mg/kg of ibalizumab every 14 days for a total of 5 doses. All patients were followed for safety for an additional 7 to 8 weeks. ^ Main Outcome Measures: Clinical and laboratory assessments of safety and tolerability of multiple administrations of ibalizumab in HIV-infected patients. Secondary measures of efficacy include HIV-1 RNA (viral load) measurements. ^ Results: 21 patients were treatment-experienced and 1 was naïve to HIV therapy. Six patients were failing despite therapy and 15 were on no current HIV treatment. Mean baseline viral load (4.78 log 10; range 3.7-5.9) and CD4+ cell counts (332/μL; range 89-494) were similar across cohorts. Mean peak decreases in viral load from baseline of 0.99 log10(1.11 log10, and 0.96 log 10 occurred by Wk 2 in Cohorts A, B and C, respectively. Viral loads decreased by >1.0 log10 in 64%; 4 patients viral loads were suppressed to < 400 copies/mL. Viral loads returned towards baseline by Week 9 with reduced susceptibility to ibalizumab. CD4+ cell counts rose transiently and returned toward baseline. Maximum median elevations above BL in CD4+ cell counts for Cohorts A, B and C were +257, +198 and +103 cells/μL, respectively and occurred within 3 Wks in 16 of 22 subjects. The half-life of ibalizumab was 3-3.5 days and elimination was characteristic of capacity-limited kinetics. Administration of ibalizumab was well tolerated. Four serious adverse events were reported during the study. None of these events were related to study drug. Headache, nausea and cough were the most frequently reported treatment emergent adverse events and there were no laboratory abnormalities related to study drug. ^ Conclusions: Ibalizumab administered either weekly or bi-weekly was safe, well tolerated, and demonstrated antiviral activity. Further studies with ibalizumab in combination with standard antiretroviral treatments are warranted.^

Sentencia C-355/06

El 10 de mayo de 2006, la Corte Constitucional de Colombia produjo un fallo histórico a favor de los derechos humanos de las mujeres en el país. Mediante la Sentencia C-355/06 del 10 de mayo de 2006, la Sala Plena del Tribunal Constitucional decidió despenalizar la práctica del aborto en tres circunstancias específicas