Interleukin 4 signals through two related pathways.

The interleukin 4 (IL-4) signaling pathway involves activation, by tyrosine phosphorylation, of two distinct substrates, a signal-transducing factor (STF-IL4) and the IL-4-induced phosphotyrosine substrate (4PS). It is not known whether the IL-4-mediated activation of these substrates occurs via related or distinct signaling pathways. We report that 32D cells, an IL-3-dependent myeloid progenitor cell line in which no phosphorylated 4PS is found, activate high levels of STF-IL4 in response to IL-4. Consistent with the known requirement for 4PS or insulin receptor substrate 1 (IRS-1) in IL-4-mediated mitogenesis, activation of STF-IL4 in 32D cells is not sufficient for IL-4-inducible c-myc expression. In addition, we have examined the ability of 32D cells transfected with different truncation mutants of the human IL-4 receptor to activate Jak-3 kinase and STF-IL4 in response to human IL-4. As in the case of 4PS/IRS-1, we have found that activation of both Jak-3 and STF-IL4 requires the presence of the IL-4 receptor region comprising aa 437-557. The finding that the same region of the IL-4 receptor is required for the induction of both 4PS/IRS-1 and STF-IL4 suggests that the IL-4-stimulated activation of these two substrates might involve common factors.

Composition of basalts from the north part of the Bougault anomaly, Mid-Atlantic Ridge 15°N

A quantitative model of development of magmatic and ore-magmatic systems under crests of mid-ocean ridges is constructed. Correct physical models of melting zone formation in approximation to active spreading, non-stationary dynamics of magma intrusion from a center of generation, filling of magma chambers of various shapes, feeding of fissure-type volcanoes, and retrograde boiling of melts during solidification of intrusive bodies beneath axial zones of spreading in crests of ridges are proposed. Physicochemical and mathematical theories of disintegration of multi-component solutions, growth of liquational drops of ore melts, and sublimation of components from magmatic gases are elaborated. Methods for constructing physically correct models of heat and mass transfer in heterophase media are devised. Modeling of development of magmatic and ore-magmatic systems on the basis of the Usov-Kuznetsov facies method and the Pospelov system approach are advanced. For quantitative models numerical circuits are developed and numerical experiments are carried out.

The Congressional globe.

Edited by Blair and Rives, 23d-30th Congress; by John C. Rives, 31st-38th Congr., 1st sess.; by F. & J. Rives, 38th Cong., 2d sess.-39th Cong.; by F. & J. Rives & George A. Bailey, 40th-42d Cong.

Report of the Architect of the Capitol for the period ...

Report dated December 23, 1851, issued as Senate Ex. doc. 33, 32d Cong., 1st sess.

Contributions to Canadian biology.

1901, 1902-1905, 1911-1914 (fasc. I-II) 1914-1915-1917-1918 issued in the series of Sessional papers as Sessional papers: 1902, no. 22a; 1907, no. 22a; 1915, no. 39b; 1916, no. 38b; 1917, no. 38a; and 1918, no. 38a, respectively.

Atti del ... Congresso per la storia del Risorgimento italiano tenutosi in ... nel ...

23d-24th (1935-36), 31st-32d (1952-53) issued as its Biblioteca scientifica, ser. 2: Memorie, v. 13-14, 17-18; 33d (1954) etc. issued as its Biblioteca scientifica. Atti dei Congressi, v. 1, etc.

Report of the State Superintendent of Public Instruction.

Title varies slightly.

Queensland geographical journal, including the proceedings of the Royal Geographical Society of Australasia, Queensland.

Issued by the Society under an earlier name: Geographical Society of Australasia.

The Congressional globe ... : [23d Congress to the 42d Congress, Dec. 2, 1833, to March 3, 1873]

Messages of the President and reports of cabinet officers are included in the appendixes to the close of the 39th Cong., also laws passed at the 2d sess., 32d Cong., to the 3d sess., 42d Cong., and a detailed statement of the appropriations made during each session, 32d Cong., 2d sess.-37th Cong., 1st sess., inclusive. The proceedings of the Senate in the trial of Andrew Johnson, forms a supplement to the 40th Cong., 2d sess.

Indian agricultural statistics.

Vols. for 1896/97-1900/01--38/39 in 2 v.: v. 1 contains data for British India; v. 2, for the native states. Vols. for 1939/40-42/43--1943/44-46/47 in 2 v.: v. 1 contains data for the Indian provinces; v. 2, for the Indian states. Vols. for 1947/48-48/49- in 2 v.: v. 1, Summary tables; v. 2, Detailed tables.

Obituary addresses on the occasion of the death of the Hon. Henry Clay, a senator of the United States from the state of Kentucky,

Mode of access: Internet.

Proceedings of the State Historical Society of Wisconsin at its ... annual meeting.

1887-91, annual meeting held in January; 1891- in December.

Official proceedings of the annual convention - American Society of Municipal Engineers

Appendixes to v. 37, 39, 1931, '34, comprise Standard specifications of the American Society of Municipal Engineers

Annual report of the American Institute of the City of New York

1st-<32d> 1841-<1871/72> issued also as Legislative documents.

Report of proceedings

List of places of meeting, etc., 1888-1922: 33d, 1921, p. [10]