Hebraicorum Bibliorum Veteris Testamenti Latina interpretatio ; Nouum Testamentum Græce, cum vulgata interpretatione Latina Græci contextus lineis inserta ... ; Communes et familiares Hebraicæ linguæ idiotismi ... / opera olim Xantis Pagnini Lucensis ; nunc vero Benedicti Ariae Montani ...studio

Dos Port., una al comienzo que corresponde al Nuevo Testamento en griego; y otra al final correspondiente al Antiguo Testamento en hebreo

Hebraicorum Bibliorum Veteris Testamenti Latina interpretatio ; Nouum Testamentum Græce, cum vulgata interpretatione Latina Græci contextus lineis inserta ... ; Communes et familiares Hebraicæ linguæ idiotismi ... / opera olim Xantis Pagnini Lucensis ; nunc vero Benedicti Ariae Montani ...studio

Dos Port., una al comienzo que corresponde al Nuevo Testamento en griego; y otra al final correspondiente al Antiguo Testamento en hebreo

HG 186.9-187.0 D.E-2

Coarse grained sediment with small patches of a fine grained domain. The domain may contain organic material. Lineations and minor grain stack present throughout the section.

HG 186.15-186.25-2

Major grains crushing towards the top left with two fine grained domains in coarse grained sediment.

HG 186.55-186.75-2

Fine grained sediment, quite structure-less.

Direct support and general support maintenance repair parts and special tools list (including depot repair parts and special tools list) for automatic telephone central offices AN/TTC-38(V)1 (NSN 5805-00-186-0681) and AN/TTC-38(V)2 (NSN 5805-00-186-0640).

"17 September 1982"--[Vol.] 2.

Derivatives of 1,3,5-triamino-1,3,5-trideoxy-cis-inositas versatile pentadentate ligands for protein labeling with Re-186/188. Prelabeling, biodistribution, and X-ray structural studies

The pentadentate H(3)bhci [1,3,5-trideoxy-1,3-bis((2-hydroxybenzyl)amino)-cis-inistol] and its bifunctionalized analogue H(3)bhci-glu-H [1,3,5-trideoxy-1,3-bis((2-hydroxybenzyl)amino)-5-glutaramido-cis-inositol] were synthesized, and their coordination chemistry was investigated with inactive rhenium, with no carrier added Re-188 and with carrier added Re-186. The neutral Re(V) complexes [ReO-(bhci)] and [ReO(bhci-glu-H)] are formed in good yields starting from [ReOCl3(P(C6H5)(3))(2)] or in quantitative yield directly from [(ReO4)-Re-186/188](-) in aqueous solution by reduction with Sn(II) or Sn(0). The X-ray structures of [ReO(bhci)] and [ReO(bhci-glu-H)] were elucidated revealing pentadentate side on coordination of the ligands to the Re=O core. The basic cyclohexane frame adopts a chair form in the case of [ReO(bhci)] and a twisted boat form in the case of [ReO(bhci-glu-H)]. [ReO(bhci)] crystallizes in the monoclinic space group C2/c with a = 27.425(3), b = 14.185(1), c = 19.047(2) Angstrom, and beta = 103.64(2)degrees and [ReO(bhci-glu-H)] in the monoclinic space group P2(1)/c with a = 13.056(3), b = 10.180(1), c = 22.378(5) Angstrom and beta = 98.205(9)degrees Both Re-188 complexes are stable in human serum for at least 3 days without decomposition. After injection into mice, [ReO(bhci-glu)](-) is readily excreted through the intestines, while [ReO(bhci)] is excreted by intestines, liver, and the kidneys. TLC investigations of the urine showed exclusively the complexes [ReO(bhci-glu-H)] and [ReO(bhci)], respectively, and no decomposition products. For derivatization of antibodies, the carboxylic group of [ReO(bhci-glu-H)] was activated with N-hydroxysuccinimide, which required unusually vigorous reaction conditions (heating). The anti colon cancer antibody mAb-35 [IgG and F(ab')(2) fragment] was labeled with [(ReO)-Re-186/188(bhci-glu)] to a specific activity of up to 1.5 mCi/mg (55 MBq/mg) with full retention of immunoreactivity. Labeling yields followed pseudo-first-order kinetics in antibody concentration with the ratio of rates between aminolysis and hydrolysis being about 2. Biodistributions of Re-186-labeled intact mAb-35 as well as of its F(ab')(2) fragment in tumor-bearing nude mice revealed good uptake by the tumor with only low accumulation of radioactivity in normal tissue.