CD10 (Neutral Endopeptidase) expression in myoepithelial cells of salivary neoplasms

CD10 is a cell surface peptidase expressed in a wide variety of normal and neoplastic tissues, including breast myoepithelial cells. In salivary glands, expression of CD10 has only been used to identify neoplastic myoepithelial cells of pleomorphic adenomas and myoepithelial carcinomas. However, its accuracy in other salivary tumors with myoepithelial component has yet to be analyzed. We examined 72 salivary tumors with myoepithelial differentiation using immunohistochemical technique to detect CD10. In salivary glands, CD10 expression was not detected in myoepithelial cells. Only fibrocytes within the intralobular stroma were CD10 positive. In neoplastic myoepithelial cells, CD10 expression was found in 25.71% of benign and 32.43% of malignant neoplasms. When the different groups of tumors were compared, epithelial-myoepithelial carcinomas (EMEC) showed a stark contrast with the others (83.3% of cases with CD10 expression). Surprisingly, adenoid cystic carcinomas and basal cell adenomas were negative in 100% of the cases. Myoepitheliomas, pleomorphic adenomas, and myoepithelial carcinomas were positive in 27.7%, 30.0%, and 40% of the cases, respectively. In conclusion, salivary neoplastic myoepithelial cells gain CD10 expression in relation to their normal counterparts. However, the gain of this protein is not a sensitive marker for detecting myoepithelial cells in the majority of the tumors, except for EMEC. The high expression of CD10 by this carcinoma can be a valuable tool to separate EMEC from the tubular variant of adenoid cystic carcinomas in small incisional biopsies, where the precise diagnosis may be impossible.

Equal Rights Amendment Coalition Records - Accession 1062

The Equal Rights Amendment South Carolina Coalition Records consist of the history of the South Carolina Equal Rights Amendment (ERA), meeting minutes, petitions, votes, polls, and memorabilia from the organization. Also, includes a list of committee members from the House and the Senate leaders, newsletters, correspondence, and calendars of events.

In Silico Analysis and Immunohistochemical Characterization of NaPi2b Protein Expression in Ovarian Carcinoma With Monoclonal Antibody Mx35

Introduction: Ovarian adenocarcinoma is frequently detected at the late stage, when therapy efficacy is limited and death occurs in up to 50% of the cases. A potential novel treatment for this disease is a monoclonal antibody that recognizes phosphate transporter sodium-dependent phosphate transporter protein 2b (NaPi2b). Materials and Methods: To better understand the expression of this protein in different histologic types of ovarian carcinomas, we immunostained 50 tumor samples with anti-NaPi2b monoclonal antibody MX35 and, in parallel, we assessed the expression of the gene encoding NaPi2b (SCL34A2) by in silico analysis of microarray data. Results: Both approaches detected higher expression of NaPi2b (SCL34A2) in ovarian carcinoma than in normal tissue. Moreover, a comprehensive analysis indicates that SCL34A2 is the only gene of the several phosphate transporters genes whose expression differentiates normal from carcinoma samples, suggesting it might exert a major role in ovarian carcinomas. Immunohistochemical and mRNA expression data have also shown that 2 histologic subtypes of ovarian carcinoma express particularly high levels of NaPi2b: serous and clear cell adenocarcinomas. Serous adenocarcinomas are the most frequent, contrasting with clear cell carcinomas, rare, and with worse prognosis. Conclusion: This identification of subgroups of patients expressing NaPi2b may be important in selecting cohorts who most likely should be included in future clinical trials, as a recently generated humanized version of MX35 has been developed.

Ms. Barth. 172 - Opus imperfectum in Matthaeum

Vorbesitzer: Johannes Oppeler de Butzbach; Bartholomaeusstift Frankfurt am Main

Ms. Praed. 172 - Lateinisch-deutsches Gebetbuch

Vorbesitzer: Philippus Wischius; Dominikanerkloster Frankfurt am Main

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 664 - Weiterleitung eines Briefes und Angaben zur Quittung von 3.172 Thaler und 12 Groschen

u.a.: Geschäfte mit dem Bankhaus Muhl;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 172 - Vereherungsschreiben von Gustav Wilhelm Körber mit Hinweis auf die Verbreitung der Popularität Schopenhauers in Schlesien

u.a.: Vermittlung der Bekanntschaft durch Marie von Gayette; Hegelianismus; Schopenhauer-Schule; Rezeption von Schopenhauer in Schlesien; Jeanne Marie von Gayette; Julius Frauenstädt;

Ms. lat. oct. 172 - Loci communes philosophico-critici

Vorbesitzer: Philipp Jakob Waldschmidt