Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults.

Previously, a single nucleotide polymorphism (SNP), rs9939609, in the FTO gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC). This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to increased mortality. To investigate this further, we conducted a meta-analysis of similar data from 34 longitudinal studies including 169,551 adult Caucasians among whom 27,100 died during follow-up. Linear regression showed that the minor allele of the FTO SNP was associated with greater BMI (n = 169,551; 0.32 kg m(-2) ; 95% CI 0.28-0.32, P < 1 × 10(-32) ), WC (n = 152,631; 0.76 cm; 0.68-0.84, P < 1 × 10(-32) ) and FMI (n = 48,192; 0.17 kg m(-2) ; 0.13-0.22, P = 1.0 × 10(-13) ). Cox proportional hazard regression analyses for mortality showed that the hazards ratio (HR) for the minor allele of the FTO SNPs was 1.02 (1.00-1.04, P = 0.097), but the apparent excess risk was eliminated after adjustment for BMI and WC (HR: 1.00; 0.98-1.03, P = 0.662) and for FMI (HR: 1.00; 0.96-1.04, P = 0.932). In conclusion, this study does not support that the FTO SNP is associated with all-cause mortality independently of the adiposity phenotypes.

Arkistoluettelo 169: Fredrik Pacius

Luettelo Kansalliskirjastossa olevan Fredrik Paciuksen arkiston sisällöstä

Reforma de la enseñanza primaria : Ley 169-1965, de 21 de diciembre de 1965.

Publicación del discurso del secretario general técnico del Ministerio de Educación Nacional, en defensa del dictamen de la Comisión Nacional sobre la reforma de la ley de Enseñanza Primaria, en el que se resalta la necesidad de esta reforma para conseguir el objetivo de dignificar y elevar el nivel y calidad de este grado educativo. También, se publican las enmiendas presentadas en las Cortes al proyecto de ley aprobado por el Consejo de Ministros, así como el texto exacto de los artículos que contienen los aspectos principales de la reforma de la Enseñanza Primaria.

Revista Colóquio/Letras (nº 1/1971-nº 169/2004) e a crítica literária: Eça de Queirós/Seção Ensaio

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)