COMT Met (158) modulates facial emotion recognition in bipolar I disorder mood episodes

Background: One of the many cognitive deficits reported in bipolar disorder (BD) patients is facial emotion recognition (FER), which has recently been associated with dopaminergic catabolism. Catechol-O-methyltransferase (COMT) is one of the main enzymes involved in the metabolic degradation of dopamine (DA) in the prefrontal cortex (PFC). The COMT gene polymorphism rs4680 (Val(158)Met) Met allele is associated with decreased activity of this enzyme in healthy controls. The objective of this study was to evaluate the influence of Val(158)Met on FER during manic and depressive episodes in BD patients and in healthy controls. Materials and methods: 64 BD type I patients (39 in manic and 25 in depressive episodes) and 75 healthy controls were genotyped for COMT rs4680 and assessed for FER using the Ekman 60 Faces (EK60) and Emotion Hexagon (Hx) tests. Results: Bipolar manic patients carrying the Met allele recognized fewer surprised faces, while depressed patients with the Met allele recognized fewer "angry" and "happy" faces. Healthy homozygous subjects with the Met allele had higher FER scores on the Hx total score, as well as on "disgust" and "angry" faces than other genotypes. Conclusion: This is the first study suggesting that COMT rs4680 modulates FER differently during BD episodes and in healthy controls. This provides evidence that PFC DA is part of the neurobiological mechanisms of social cognition. Further studies on other COMT polymorphisms that include euthymic BD patients are warranted. ClinicalTrials.gov Identifier: NCT00969. (C) 2011 Elsevier B.V. All rights reserved.

Measurement of negatively charged pion spectra in inelastic p+p interactions at plab = 20, 31, 40, 80 and 158 GeV/c

We present experimental results on inclusive spectra and mean multiplicities of negatively charged pions produced in inelastic p+p interactions at incident projectile momenta of 20, 31, 40, 80 and 158GeV/c (√s = 6.3, 7.7,8.8, 12.3 and 17.3GeV, respectively). The measurements were performed using the large acceptance NA61/SHINE hadron spectrometer at the CERN super proton synchrotron. Two-dimensional spectra are determined in terms of rapidity and transverse momentum. Their properties such as the width of rapidity distributions and the inverse slope parameter of transverse mass spectra are extracted and their collision energy dependences are presented. The results on inelastic p+p interactions are compared with the corresponding data on central Pb+Pb collisions measured by the NA49 experiment at the CERNSPS. The results presented in this paper are part of the NA61/SHINE ion program devoted to the study of the properties of the onset of deconfinement and search for the critical point of strongly interacting matter. They are required for interpretation of results on nucleus–nucleus and proton–nucleus collisions.

Ms. hebr. oct. 158 - Rashi

Vorbesitzer: Abraham Merzbacher

Ms. Barth. 158 - Mainzer Diözesanbrevier (Winterteil)

Vorbesitzer: Peter von Seligenstadt; Bartholomaeusstift Frankfurt am Main

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 158 - Erläuterungen zum Schreiben an den preußischen König wegen der testamentarischen Verfügung zur Unterstützung des Invalidenhauses in Berlin

u.a.: 1848er Revolution, Mobilmachung der preussischen Armee; Diätratschläge Schopenhauers; Heimatschein; Annahme von Geschenken in der preussischen Verwaltung; Orden für Schopenhauer; Naturwissenschaft; Magd, Pudel; Alexander von Humboldt; Stricker; Geheimer Kriegsrat Stricker; Geheimer Hofrat Carl John;

Ms. Praed. 158 - Breviarium Praedicatorum

Vorbesitzer: Martinus Lugisland; Dominikanerkloster Budweis; Dominikanerkloster Frankfurt am Main

Ms.Ff.F.Stoltze 3. 158 - Brief von Wilhelm Kaulen an Friedrich Stoltze

Deutsche Latern, Kladderadatsch

Na 1 Nachlass Max Horkheimer, 538 - Korrespondenzen u.a. mit Leo Löwenthal und Franz Neumann (p. VI 14, 158 - 391)

127 Briefe zwischen Leo Löwenthal und Max Horkheimer; 2 Briefe zwischen Theodor W. Adorno und Leo Löwenthal, April 1942; 1 Brief von M. David an Leo Löwenthal, 17.02.1942; 1 Brief von Franz Neumann an Max Horkheimer;

Na 1 Nachlass Max Horkheimer, 547 - Korrespondenzen mit Leo Löwenthal (p. VI 19, 1-158)

107 Briefe zwischen Max Horkheimer und Leo Löwenthal; 10 Briefe von Max Horkheimer an Samuel H. Flowerman (Sandy); 1 Brief von Samuel H. Flowerman an Frederick Pollock, 26.03.1946; 1 Brief von Paul F. Lazarsfeld an Max Horkheimer, 10.03.1946; 1 Brief von Frederick Pollock an Robert K. Merton, 17.04.1946; 1 Brief von Samuel H. Flowerman an Frederick Pollock, 26.03.1946; 1 Brief von Robert K. Merton an Arthur W. MacMahon, 12.03.1946; 1 Brief von E. Franklin Frazier an Leo Löwenthal, 27.03.1946; 2 Briefe zwischen Margaret Nicholson und Max Horkheimer, März 1946;

Ms. lat. oct. 158 - Aristoteles-Kommentare

Vorbesitzer: Jacobus Ardenius

Itinerarios, revista de literatura y artes, no. 4, Buenos Aires, enero 2003, 158 p. Director: Hugo F. Bauzá

Fil: Sánchez, Brenda. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto Literaturas Modernas

Parente, Diego (editor). La verdad a 24 cuadros por segundo. Estudios sobre cine. Mar del Plata, Suárez, 2005, 158 p.

Fil: Alberti, Miguel.