稀土区质子滴线核~(142)Ho的β缓发质子衰变

通过重离子引起的核反应106Cd(40Ca,p3n)合成了新的β缓发质子先驱核142Ho,并且配合氦喷嘴快速带传输系统用“p-γ”符合方法对它进行了首次鉴别.观测了142Ho的β缓发质子衰变,测定其半衰期为(0.4±0.1)s.利用统计模型拟合实验估计的对质子女儿核141Tb中末态的相对分支比和缓发质子能谱,142Ho的基态自旋被指认为5,6或7.用Woods-Xason Strutinsky方法计算了142Ho的核位能面,其结果支持指认142Ho的基态自旋宇称为7-.作为副产品,还首次观测到了来自先驱核139Gd,140Tb,142Tb和143Dy的β缓发质子衰变产生的质子女儿核中的一些γ跃迁.

~(142)Ce的新激发态及其经验壳模型研究

利用 42 0MeV　82 Se轰击1 39La引起的深部非弹反应和在束γ谱学方法研究了1 4 2 Ce的中高自旋激发态 .识别出了激发能为 2 62 5,2 995和 3 83 4keV的 3个新能级 ,自旋、宇称分别被指定为 8+,9(- ) 和 1 1 (- ) .发现这些能级非常好地符合N=84偶偶核转晕能级的系统性 .利用经验壳模型计算了1 4 2 Ce的中高自旋激发态的激发能 ,计算结果比较好地重现了实验值 .对它们的结构进行了讨论 ,表明在1 4 2 Ce的中高自旋激发态中以单粒子激发为主

双奇核~(142)Pm高自旋态能级纲图

利用能量为 75— 95MeV19F束流 ,通过反应12 8Te( 19F ,5nγ) 142 Pm研究了双奇核142 Pm的高自旋态能级结构 .实验中进行了γ射线的激发函数、γ射线单谱和γ γ符合测量 .建立了激发能达 70 3 0 .0keV的142 Pm的能级纲图 ,其中包括新发现的 2 5条γ射线和 1 3个新能级 .基于实验测量的γ跃迁各向异性度 ,建议了142 Pm能级的自旋值

高产抗病春小麦新品种-高原142

小麦新品种高原142是由中国科学院西北高原生物研究所1999年从国际玉米小麦改良中心引进的高代品系筛选而来，组合为：BABAX/4/BOBWHITE/CROWN//BUCBUC/PAVON/3/VEERY#10/5/BABAX。经在该研究所平安育种试验站筛选与鉴定，

A remarkable synergic effect of water-soluble bimetallic catalyst in the hydrogenation of aromatic nitrocompounds

Hydrogenation of nitrobenzene can be catalyzed by the water-soluble catalyst PdCl2(TPPTS)(2) (TPPTS = tris(m-sulfonatophenyl)phosphine trisodium salt) under normal pressure at 65 degrees C in H2O/toluene biphasic solvent system. The exhibits higher catalytic activity and selectivity for the hydrogenation of aromatic nitrocompounds, compared with PdCl2(TPPTS)(2) or H2PtCl6 alone. The transmission electron micrographs demonstrate that the monometallic catalyst is composed of ultrafine palladium particles of almost uniform size while the particles of bimetallic catalyst are more widely distributed in size than those of the monometallic ones. (C) 1999 Elsevier Science B.V. All rights reserved.

Levantamento exploratório-reconhecimento de alta intensidade e aptidão agrícola dos solos da área compreendida entre os km 81 e 152 da Rodovia Santarém-Cuiabá e o Rio Curua-Una.

Foram estudados os solos de uma area com 390.000 ha, situada a margem esquerda da Rodovia Santarem-Cuiaba, num trecho compreendido entre a cidade de Santarem e a Ruropolis Presidente Medici, no Estado do Para, com o objetivo de fornecer elementos basicos ao planejamento para ocupacao da area, atraves projetos de colonizacao. O trabalho constou do levantamento pedologico e posterior determinacao da aptidao agricola dos diferentes solos identificados e mapeados. Predominam na area os Latossolos e os podzolicos, ocorrendo em pequenas proporcoes as areias Quartzosas. As principais limitacoes se referem a fertilidade e a deficiencia de agua, enquanto que nos podzolicos, porquanto existam as limitacoes supracitadas, e o relevo que exerce em sua maioria, o principal papel de limitacoes das terras para o aproveitamento agropastoril. De acordo com o sistema de aptidao agricola adotado, os Latossolos, apesar de apresentarem baixa fertilidade e alta saturacao de aluminio, dada as suas propriedades fisicas, podem ser utilizados em empreendimentos agropecuarios com bons resultados, assim como os Podzolicos de relevo forte ondulado, recomenda-se a sua utilizacao para pastagem plantada ou silvicultura, e, para as Areais Quartzosas a melhor indicacao e a silvicultura.

Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells.

We have previously shown that treatment of prostate cancer and melanoma cells expressing GRP78 on their cell surface with antibody directed against the COOH-terminal domain of GRP78 upregulates and activates p53 causing decreased cell proliferation and upregulated apoptosis. In this report, we demonstrate that treatment of 1-LN prostate cancer cells with this antibody decreases cell surface expression of GRP78, Akt(Thr308) and Akt(Ser473) kinase activities and reduces phosphorylation of FOXO, and GSK3beta. This treatment also suppresses activation of ERK1/2, p38 MAPK and MKK3/6; however, it upregulates MKK4 activity. JNK, as determined by its phosphorylation state, is subsequently activated, triggering apoptosis. Incubation of cells with antibody reduced levels of anti-apoptotic Bcl-2, while elevating pro-apoptotic BAD, BAX and BAK expression as well as cleaved caspases-3, -7, -8 and -9. Silencing GRP78 or p53 gene expression by RNAi prior to antibody treatment abrogated these effects. We conclude that antibody directed against the COOH-terminal domain of GRP78 may prove useful as a pan suppressor of proliferative/survival signaling in cancer cells expressing GRP78 on their cell surface.

¡Abre los ojos! Un proyecto de mejora educativa para la prevención de drogas en adolescentes

La Educación para la Salud (EpS) es un tema transversal del currículo que adolece de propuestas didácticas novedosas para la intervención pedagógica. El objetivo del trabajo que se presenta es poner en marcha un plan de mejora para la prevención de drogadicciones en adolescentes. Para ello, se ha trabajado con un total de 142 estudiantes de 3º de Educación Secundaria Obligatoria (ESO) con edades comprendidas entre los 14 y los 16 años que cursan estudios en el Instituto “Francisco Salzillo” de la localidad de Alcantarilla (Murcia). Concretamente, este artículo da luz al Proyecto ¡Abre los ojos!, que forma parte del Plan de Acción Tutorial (PAT) y del Plan de Mejora para la Prevención de Drogas (PMPD) propuesto desde el Departamento de Orientación. Se exponen ad hoc las actividades implementadas durante las 3 sesiones trabajadas con cada uno de los 6 grupos-clase escolarizados en este nivel. Haciendo uso de la reflexión-acción, el alumnado ha desarrollado una conciencia crítica acerca de los riesgos que entraña para la salud el consumo de drogas. Asimismo, mediante la técnica de grupos de discusión los discentes han realizado un interesante debate cuyas ideas han sido organizadas en torno a tres aspectos clave: causas por las que se empieza a consumir, cómo evitar caer en las drogas, y alternativas de ocio y tiempo libre para una vida saludable. Finalmente, se especifica la necesidad de abordar tareas de prevención en los centros educativos así como de facilitar información y de resolver las inquietudes de los jóvenes acerca de esta temática.

Meta-analysis of 32 genome-wide linkage studies of schizophrenia

A genome scan meta-analysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disorders. The primary GSMA divided the autosomes into 120 bins, rank-ordered the bins within each study according to the most positive linkage result in each bin, summed these ranks (weighted for study size) for each bin across studies and determined the empirical probability of a given summed rank (P-SR) by simulation. Suggestive evidence for linkage was observed in two single bins, on chromosomes 5q (142-168 Mb) and 2q (103-134 Mb). Genome-wide evidence for linkage was detected on chromosome 2q (119-152 Mb) when bin boundaries were shifted to the middle of the previous bins. The primary analysis met empirical criteria for 'aggregate' genome-wide significance, indicating that some or all of 10 bins are likely to contain loci linked to SCZ, including regions of chromosomes 1, 2q, 3q, 4q, 5q, 8p and 10q. In a secondary analysis of 22 studies of European-ancestry samples, suggestive evidence for linkage was observed on chromosome 8p (16-33 Mb). Although the newer genome-wide association methodology has greater power to detect weak associations to single common DNA sequence variants, linkage analysis can detect diverse genetic effects that segregate in families, including multiple rare variants within one locus or several weakly associated loci in the same region. Therefore, the regions supported by this meta-analysis deserve close attention in future studies. Molecular Psychiatry (2009) 14, 774-785; doi:10.1038/mp.2008.135; published online 30 December 2008