Inhibition of the miR-143/145 cluster attenuated neutrophil differentiation of APL cells

MicroRNAs can influence hematopoietic cell lineage commitment and aberrant expression of hematopoietic miRNAs contributes to AML pathology. We found that miR-143 and miR-145 expression is significantly repressed in primary AML patient samples as compared to neutrophils of healthy donors. Further analysis revealed impaired neutrophil differentiation of APL cells upon inhibition of miR-145 expression. Lastly, we identified p73 as transcriptional regulator of miR-143/145 during neutrophil differentiation of APL cells. Our data suggest that low miR-145 levels in APL, possibly due to aberrant expression of p73 transcription factors, contribute to the differentiation block seen in this disease.

Ms. hebr. oct. 143 - Sefer tagin

Vorbesitzer: Eljāqīm Carmoly; Abraham Merzbacher

Ms. Barth. 143 - Margarita Decreti

Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 143 - Anfrage nach der Qualität der Übersetzung des Oupnek'hat von Thaddäus Anselm Rixner 1808

u.a.: Portrait Schopenhauers von der Hermannschen Buchhandlung; Museum Frankfurt; 2. Auflage der Parerga und Paralipomena, Preisschrift Leipziger Fakultät; Immanuel Kant; Friedrich Schleiermacher; Thaddaeus Anselm Rixner;

Ms. Praed. 143 - Manipulus florum

Vorbesitzer: Dominikanerkloster Frankfurt am Main

Ms.Ff.F.Stoltze 3. 143 - Brief von Karl Holthof an Friedrich Stoltze

Demokratischer Verein

Ms. Ff. Mus. 869 - Dom. XXIII. post Trinit. : der Gottlose ist wie ein Wetter, das überhin gehet p. ; à 2. hautbois, 2. violin, 1. viola, canto, alto, tenore, basso con i ripieni, violoncello, violino bassono ed organo

di Telemann. [Text: Gottfried Simonis]

Na 1 Nachlass Max Horkheimer, 675 - Forschungsprojekte über Antisemitismus, Vorurteil, Autorität: Einzeluntersuchungen (p. IX 143)

Institut of Social Research: "Studies in Antisemitism. Volume II: III. American Antisemitic Agitators"; enthält: Studien über Martin Luther Thomas, Georg Allison Phelps und 'Conversations with Antisemitis'; Typoskript, gebunden, 436 Blatt;

Ms. lat. oct. 143 - Theologische Sammelhandschrift

Die Foliierung geht nur bis Bl. 276; zusätzlich gibt es das Blatt 120a.

Geochemical parameters of sediments and water of the Black Sea, data of Cruise 8 of R/V Vityaz-2

The book presents results of comprehensive geological investigations carried out during Cruise 8 of R/V "Vityaz-2" to the western part of the Black Sea in 1984. Systematic studies in the Black Sea during about hundred years have not weakened interest in the sea. Lithological and geochemical studies of sediments in estuarine areas of the Danube and the Kyzyl-Irmak rivers, as well as in adjacent parts of the deep sea and some other areas were the main aims of the cruise. Data on morphological structures of river fans, lithologic and chemical compositions of sediments in the fans and their areal distribution, forms of occurrence of chemical elements, role of organic matter and gases in sedimentation and diagenesis are given and discussed in the book.