DOCPAL resúmenes sobre población en América Latina: 141-001

Contiene resúmenes bibliográficos de documentos sobre población y temas relacionados que se producen en América Latina y el Caribe, publicados entre 1987-1989.

O papel das argininas alfa-92 e alfa-141 na regulação das propriedades funcionais de hemoglobinas por íons cloreto

The oxygenation of human Hb (HbA) demands a three state model: two deoxy states To and Tx, free and complexed with anions respectively, and an oxy R state. The regulation between these states is modulated by the presence of anions, such as chloride, that binds to T state. The b inding if chloride, however, remains controversial. The aim of this work is the study of arginines 92a (a1ß2 interface) and 141a (C-terminal) as chloride binding sites. To investigate that, we have studied 92 and 141 site directed mutant species: natural mutants Hb J-Cape-Town (R92Q), desArg (R141Δ), Chesapeake (R92L), and the constructed Chesapeake desArg (R92L,141Δ). We expressed Hbs in Escherichia coli and purified. Through oxygen binding curves we measured affinity and cooperativity, in function of water effect and Bohr effect in presence and absence of chloride. Structural features were obtained through 1H NMR spectroscopy Oxygen binding properties and Bohr effect measured indicated a higher affinity and lower cooperativity in absence and presence of chloride for all mutants. Structural changes represent functional aspects of mutant Hbs, such as a significant rise in affinity or a change in cooperativity. Water activity studies conducted as a function of chloride concentration showed that the only Hb desArg follows the thre state model. The other mutant Hbs do not exhibit the Tx state, a fact confirmed by the number of water molecules bound to each Hb during the deoxy-oxy transition. This behavior suggests that the Arginine 92 site could be responsible for chloride binding to Hb, since oxygenation of 92 mutant Hbs cannot be adjusted by the three state model. However, Bohr effect showed that all mutant Hbs released~1 proton in chloride presence, different from HbA that releases ~2, suggesting a role for 141 arginine in the tertiary and quaternary Bohr effect.

O papel das argininas α-92 e α-141 na regulação da função de hemoglobinas por íons cloreto

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Flora polínica da reserva do parque estadual das fontes do Ipiranga (São Paulo, SP, Brasil). Famílias: 141-Boraginaceae e 149-Gesneriaceae

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Final Testimony on LR 141: Status of Nebraska Forest Service

Good morning, Chairman Wehrbein and members of the Appropriations Committee. I am John Owens, and I serve as Vice - President and Vice Chancellor of the Institute of Agriculture and Natural Resources at the University of Nebraska. Thank you for allowing me the opportunity to speak with you regarding Legislative Resolution 141 on the Nebraska Forest Service.

Ms. hebr. oct. 141 - Shaʹare tsedeḳ

Vorbesitzer: Abraham Merzbacher

Ms. Barth. 141 - Apologetica. De contractibus. Bartolus de Saxoferrato

Vorbesitzer: Johannes Oppeler de Butzbach; Bartholomaeusstift Frankfurt am Main

Ms. lat. qu. 141 - Peul de Liptako. Vocabulaires recueilli à Dori. Vocabulaire des langues parlées dans le Cercle de Dori

Alte Signatur: Wq 535; Akzessionsnummer: 61727710

Ms. Praed. 141 - Casus summarii super Decretales

Vorbesitzer: Heinrich Brinzel (Brunsel); Johannes Usungen; Johannes Styrne; Dominikanerkloster Frankfurt am Main

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 863 - Einladung nach Berlin

abgedruckt in: Schopenhauer-Jahrbuch 30 (1943), S. 210; Unterstreichungen Schopenhauers

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 141 - Darstellung des hohen Stellenwerts Schopenhauers für die Philosophie

u.a.: Pantheismus; Übersendung "nassauischer Programme"; Kritik an so genannte Kathederphilosophen; Julius Frauenstädt;