Evaluation of quality of life related to i-131 therapy in patients with well-differentiated thyroid cancer and emphasis in salivary morbidity: a follow up study after treatment

To evaluate the impact of iodine-131 therapy received during childhood and adolescence and correlate it with the quality of life in these patients. Methods: We studied 19 patients diagnosed with cancer in childhood or adolescence who underwent thyroidectomy and supplemental therapy with I-131. We also recruited a control group of healthy subjects with the same demographic parameters. All patients were subjected to a scintigraphy examination of the salivary glands, and were also asked to complete a questionnaire in order to assess their overall quality of life. In addition, a more specific questionnaire for patients with head and neck cancer was also given to all study participants. Results: The quantitative and qualitative analyses of the salivary glands showed functional deficits with greater involvement of the parotid gland for volume, concentration and excretion. The right submandibular gland showed significant changes for volume in the patient group. The questionnaires made it possible to observe significant differences between the patient and control groups for symptoms such as thick saliva, dry mouth and speech problems. Conclusion: In spite of being very effective and widely used, iodine radionuclide therapy is correlated with a lower quality of life in young people.

Rock Hill Fire Department Records - Accession 242 - M102 (131)

The Rock Hill Fire Department Records consist correspondence from W.H. Wylie, for whom Lake Wylie is named, to prominent Rock Hillian Mr. W.T. Roddey and to the Rock Hill Fire Department. Also included is a program book for the 33rd Annual Convention of South Carolina State Firemen’s Association held in Rock Hill in 1928. The program book lists officers of the Association, committee appointments, fire chiefs, in SC, Rock Hill city officials with brief biographical sketches and sketches of the history of SC State Firemen’s Association, city of Rock Hill and Winthrop College.

Radiolabeling of defined polymer architectures with fluorine-18 and iodine-131 for ex vivo and in vivo evaluation : visualization of structure-property relationships

Nuclear medicine imaging techniques such as PET are of increasing relevance in pharmaceutical research being valuable (pre)clinical tools to non-invasively assess drug performance in vivo. Therapeutic drugs, e.g. chemotherapeutics, often suffer from a poor balance between their efficacy and toxicity. Here, polymer based drug delivery systems can modulate the pharmacokinetics of low Mw therapeutics (prolonging blood circulation time, reducing toxic side effects, increasing target site accumulation) and therefore leading to a more efficient therapy. In this regard, poly-N-(2-hydroxypropyl)-methacrylamide (HPMA) constitutes a promising biocompatible polymer. Towards the further development of these structures, non-invasive PET imaging allows insight into structure-property relationships in vivo. This performant tool can guide design optimization towards more effective drug delivery. Hence, versatile radiolabeling strategies need to be developed and establishing 18F- as well as 131I-labeling of diverse HPMA architectures forms the basis for short- as well as long-term in vivo evaluations. By means of the prosthetic group [18F]FETos, 18F-labeling of distinct HPMA polymer architectures (homopolymers, amphiphilic copolymers as well as block copolymers) was successfully accomplished enabling their systematic evaluation in tumor bearing rats. These investigations revealed pronounced differences depending on individual polymer characteristics (molecular weight, amphiphilicity due to incorporated hydrophobic laurylmethacrylate (LMA) segments, architecture) as well as on the studied tumor model. Polymers showed higher uptake for up to 4 h p.i. into Walker 256 tumors vs. AT1 tumors (correlating to a higher cellular uptake in vitro). Highest tumor concentrations were found for amphiphilic HPMA-ran-LMA copolymers in comparison to homopolymers and block copolymers. Notably, the random LMA copolymer P4* (Mw=55 kDa, 25% LMA) exhibited most promising in vivo behavior such as highest blood retention as well as tumor uptake. Further studies concentrated on the influence of PEGylation (‘stealth effect’) in terms of improving drug delivery properties of defined polymeric micelles. Here, [18F]fluoroethylation of distinct PEGylated block copolymers (0%, 1%, 5%, 7%, 11% of incorporated PEG2kDa) enabled to systematically study the impact of PEG incorporation ratio and respective architecture on the in vivo performance. Most strikingly, higher PEG content caused prolonged blood circulation as well as a linear increase in tumor uptake (Walker 256 carcinoma). Due to the structural diversity of potential polymeric carrier systems, further versatile 18F-labeling strategies are needed. Therefore, a prosthetic 18F-labeling approach based on the Cu(I)-catalyzed click reaction was established for HPMA-based polymers, providing incorporation of fluorine-18 under mild conditions and in high yields. On this basis, a preliminary µPET study of a HPMA-based polymer – radiolabeled via the prosthetic group [18F]F-PEG3-N3 – was successfully accomplished. By revealing early pharmacokinetics, 18F-labeling enables to time-efficiently assess the potential of HPMA polymers for efficient drug delivery. Yet, investigating the long-term fate is essential, especially regarding prolonged circulation properties and passive tumor accumulation (EPR effect). Therefore, radiolabeling of diverse HPMA copolymers with the longer-lived isotope iodine-131 was accomplished enabling in vivo evaluation of copolymer P4* over several days. In this study, tumor retention of 131I-P4* could be demonstrated at least over 48h with concurrent blood clearance thereby confirming promising tumor targeting properties of amphiphilic HPMA copolymer systems based on the EPR effect.

Gesänge der Weihe : Psalm 131 und 23 ; für Bariton oder M.-Sopran

komponiert von H. Fabisch

Ms. hebr. oct. 131 - Sefer Segulot

Vorbesitzer: Franz Brauner, Geherrich; Abraham Merzbacher

Ms. Barth. 131 - Nocturnale für St. Martin in Mainz (Sommerteil)

Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Ms. Praed. 131 - Glossaria

Vorbesitzer: Dominikanerkloster Frankfurt am Main;

Na 1 Nachlass Max Horkheimer, 4 - Korrespondenzen u.a. mit Richard Bach (p. I 2, 131-358)

24 Briefe zwischen Richard Bach und Max Horkheimer, 1938-1940; 2 Briefe zwischen Alfred Chalk und Max Horkheimer, 17.10.1939, 14.11.1939; 3 Briefe von Morduch Lexandrowitsch und der American Consulate General, 1939; 4 Briefe von der American Consulate General und Max Horkheimer, 1938-1939; 1 Brief von Max Horkheimer an das Amtstgericht Berlin, 15.03.1939; 1 Brief von Max Horkheimer an Stiedry, 05.12.1938; 1 Brief von Max Horkheimer an den Collector of Custom, 26.10.1938; 2 Briefe zwischen Josef Maier und Carson Alexandrowitsch, 28.06.1938, 29.06.1938; 1 Brief von Margarete Baruch an Alice Maier, 11.04.1938; 1 Brief von Emanuel List an Carson Alexandrowitsch, 23.02.1938; 1 Abschrift des Briefes von der Metropolitan Opera Association New York an Morduch Lexandrowitsch, 22.02.1938; 1 Brief von Jacques Barzun an Max Horkheimer, 09.07.1947; 4 Briefe zwischen K. Baschwitz und Max Horkheimer, 1938-1946; 2 Briefe zwischen E. Bauer und Max Horkheimer, 08.04.1935, 27.05.1935; 4 Briefe zwischen Fritz Bauer und Max Horkheimer, 1937-1938; 2 Briefe zwischen Lina Bauer und Max Horkheimer, 20.07.1942, 16,08,1942; 4 Briefe zwsichen Rudolf Bauer und Max Horkheimer, 1937; 15 Briefe zwischen Gertrud Bauer und Max Horkheimer, 1938-1941; 1 Brief von Max Horkheimer an den Collector of Customs, 15.03.1940; 2 Briefe zwischen I. Hannah Davidson vom Jewish Community Center San Francisco und Max Horkheimer, 19.09.1938, 29.09.1938; 2 Briefe zwsichen I. Bauer und Max Horkheimer, 25.09.1938, 29.09.1938; 1 Brief von Max Horkheimer an Klopfer, 27.09.1938; 3 Briefe zwischen Y.M.H.A. - Y.W.H.A The Jewish Center of Saint Louis und Max Horkheimer, 19.09.1938, 1938; 1 Brief von Max Horkheimer an Julius Rosenberg, 17.09.1938; 1 Brief von Max Horkheimer an das Jwish Center Salt Lake City, Utah, 07.09.1938; 1 Brief von Max Horkheimer an das Jewish Community Center San Fransisco, 07.09.1938; 3 Briefe zwischen dem New York Section of the National Council of Jewish Women und Max Horkheimer, 07.04.1938, 1938; 2 Briefe zwischen Baum und Max Horkheimer, 12.03.1946, 25.05.1946; 1 Brief von Max Horkheimer an Charles A. Beard , 12.12.1934; 1 Brief von Charles A. Beard an C. A. Beard; 5 Briefe von Friedrich Pollock an Charles A. Beard, 1940-1941; 5 Briefe zwischen Lilo Beck und Max Horkheimer, 1940-1941; 7 Briefe zwischen Maximilian Beck und Max Horkheimer, 1939-1940; 1 Brief von Paul Tillich an Max Horkheimer , 01.10.1940; 1 Brief von dem Emergency Committee in Aid of Displaced Foreign Scholars New York an Max Horkheimer, 19.04.1940; 5 Briefe zwischen Konrad Bekker und Max Horkheimer, 1936-1939; 2 Briefe von Max Horkheimer an Ludwig Bendix, 1921, 1937; 1 Brief von Peter Bendmann an Max Horkheimer; 1 Brief von Max Horkheimer an Ruth Benedict, 30.07.1937; 1 Brief von Eric Russel Bentley an Max Horkheimer, 30.01.1945; 1 Brief von George Berg an Max Horkheimer, 12.07.1945; 2 Briefe zwischen Egon Bergel und Max Horkheimer, 18.08.1938, 22.08.1938; 1 Brief von Marie Jahoda an Max Horkheimer, 14.07.1928; 1 Brief von Theodor W. Adorno an Kurt Bergel, 09.09.1939; 15 Briefe zwischen Klaus Berger und Max Horkheimer, 1936-1943; 1 Brief von Frederick Pollock an Philip M. Hayden von der Columbia University New York, 05.03.1942; 1 Brief von Hans Venedey an Max Horkheimer, 05.03.1938; 1 Brief von Max Horkheimer an Ida Berger-Chevant, 18.02.1939;

Die Rechtsstellung der Reichspensionäre : (Artikel 33 (5), 3, 14, 19, 123 (1), 131, 134 Grundgesetz. § 77 des Gesetzes zu Art. 131 GG vom 11.5.51)

George Tzschirner

Na 1 Nachlass Max Horkheimer, 56 - Korrespondenzen u.a. mit Felix Weil (p. I 26, 131-348)

12 Briefe zwischen Anna Weil und Max Horkheimer, 1935-1936; 82 Briefe und Beilage zwischen Felix Weil, Margot de Weil und Max Horkheimer, 1934-1941; 1 Brief von D. Charnass an Felix Weil, 25.04.1936; 4 Briefe zwischen Dolson Wood Company und Max Horkheimer, 16.05.1941, 19.05.1941; 1 Brief von Max Horkheimer an das American Consul General Havana, 21.03.1941; 1 Brief von Max Horkheimer an Byron H. Uhl, 07.01.1941; 2 Brief zwischen Dorothy B. Padwa und Max Horkheimer, 01.03.1940, 05.03.1940; 1 Brief von Max Horkheimer an Collector of Customs, 08.10.1938; 1 Brief von D. Charnass an Felix Weil, 25.04.1936; 2 Briefe zwischen D. Charnass und Charles Rosenheck, 25.04.1936; 1 Zeugnis von The State Education Department an Charles Rosenheck, 25.04.1936; 1 Zeugniskopie, 24.04.1936; 1 Brief von Charles Rosenheck über Felix Weil, 23.04.1936; 1 Bescheinigung von Albert Marinelli, 24.04.1936; 3 Briefe zwischen George Weil und Max Horkheimer, 22.02.1937, 1937; 2 Briefe zwischen Georg Weil und Max Horkheimer, 06.04.1942, 08.04.1942; 1 Brief von Hans Weil an Max Horkheimer, 01.01.1939; 2 Briefe von Max Horkheimer an Duggan; 1 Brief und Beilage von Hans Weil an Paul Tillich, 11.10.1940; 1 Brief von Max Horkheimer an Hilde Frankel, 12.10.1940; 3 Briefe und 1 Beilage Juliana Weil, 06.06.1936, 1936; 1 Brief von Weinbaum an Max Horkheimer; 2 Briefe zwischen Jacob Weinberger und Max Horkheimer, 20.02.1946, 28.02.1946; 2 Briefe zwischen Ria Weinig, Margit Weinig und Max Horkheimer, 20.07.1949, 29.07.1949; 1 Brief und Beilage von B. Weinryb an Max Horkheimer, 04.03.1941; 1 Brief von Philipp Weintraub an Max Horkheimer, 20.11.1937;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 131 - Mitteilung einer von Dr. Swoboda verfassten Publikation über den Unterschied zwischen Tieren und Pflanzen

u.a.: Über das Sehen und die Farben; Parerga und Paralipomena, 2. Auflage; Geschichte der Philosophie; Ankündigung des Besuchs in Frankfurt am Main; Zitat aus dem Evangelium; Dr. Swoboda; Isaak Newton; Johann Wolfgang von Goethe; Lipsius; Seneca; Friedrich Schleiermacher; Spinoza;