(Table 1) Pore-water composition of ODP Leg 126 sites

The Ocean Drilling Program Leg 126 sites may be classified into two categories depending on the presence (Group I: Sites 787, 792, and 793) or absence (Group II: Sites 788, 790, and 791) of steep concentration gradients. Shipboard X-ray diffraction analyses of bulk sediments from Group I sites revealed the presence of a number of diagenetic minerals (some of which are incompatible), but no systematic diagenetic zonation. The results of the chemical analyses of the pore waters from Group I have been used to estimate the activities of dissolved species. Thermodynamic analyses of the composition of the pore waters and the stability of authigenic minerals (gypsum, zeolites, feldspars, smectites, chlorites, and micas) show that the pore waters are close to equilibrium with most of the observed phases. Thus, only a small perturbation of the system (substitution in minerals and fluctuations in pore-water composition, in particular, in pH and SiO2 activity) will cause any of these phases to precipitate. Therefore, one would not expect mineralogical observations to show systematic vertical zonations at these sites. It is suggested that chlorites and high-temperature zeolites are not diagenetic sensu stricto, but were eroded from volcaniclastic highs. The absence of concentration gradients at the Group II sites has been analyzed in terms of reaction kinetics, hydrothermal advection, and temperature distribution. The absence of diagenetic imprints on the pore-water concentration profiles at these sites is probably caused by the slow nucleation of silica phases.

Petrology and geochemistry of Quaternary tephras of the Izu-Bonin Arc

Quaternary marine tephras in the Izu-Bonin Arc offer significant information about explosive volcanic activities of the arc. Visual core descriptions, petrographic examinations, and chemical and grain-size analyses were conducted on tephras of backarc, arc, and forearc origin. Tephras are black and white and occur in simple and multiple modes with mixed and nonmixed ashes of black and white glass shards. The grain size distributions of the tephras are classified into three categories: coarse, white pumiceous, and fine white and black well-sorted types. The frequency of occurrence of the white and black tephras differs within the tectonic settings of the arc. Chemically, the Quaternary tephras in this region belong to low-alkali tholeiitic series with lower K2O and TiO2 than normal ordinary arc volcanic materials. Several tephras from different sites along the forearc correlate with each other and with tephras in the Shikoku Basin site and with Aogashima volcanics. These volcanic ashes resemble those in other backarc rifting areas, such as in the Fiji, Okinawa (Ryukyu), and Mariana regions.

Geochemistry of Pliocene-Pleistocene volcanic rocks from the Izu Arc

The igneous geochemistry of lavas and breccias from the basement of Sites 790 and 791, and pumice clasts from the Pliocene-Pleistocene sedimentary section of Sites 788, 790, 791, and 793 were studied. Arc volcanism became silicic about 1.5 m.y. before the inception of rifting in the Sumisu Rift at 2 Ma, but eruption of these silicic magmas reflects changes in stress regime, especially during the last 130,000 yr, rather than crustal anatexis. Arc magmas have had a larger proportion of slab-derived components since the inception of rifting than before, but are otherwise similar. Rift basalts and rhyolites are derived from a different source than are arc andesites to rhyolites. The rift source has less slab-derived material and is an E-MORB-like source, in contrast to an N-MORB-type source overprinted with more slab-derived material beneath the arc. Rift magma types, in the form of rare pumice and lithic clasts, preceded the rift, and the earliest magmas that erupted in the rift already differed from those of the arc. The earliest large rift eruption produced an exotic explosion breccia ("mousse") despite eruption at >1800 mbsl. Although this rock type is attributed primarily to high magmatic water content, the clasts are more MORB-like in trace element and isotopic composition than are modern Mariana Trough basalts. After rifting began, arc volcanism continued to be predominantly silicic, with individual pumice deposits containing clasts that vary in composition by about 5 wt% SiO2, or about as much as in historical eruptions of submarine Izu Arc volcanoes. The overall variations in magma composition with time during the inception of arc rifting are broadly similar in the Sumisu Rift and Lau Basin, though newly tapped OIB-type mantle seems to be present earlier during basin formation in the Sumisu than Lau case.

Mineralogy of volcaniclastic sands from the Izu-Bonin Arc

Modal compositions of volcaniclastic sands recovered on Leg 126 of the Ocean Drilling Project (Izu-Bonin island arc and Sumisu Rift) are similar to those from other intraoceanic island arcs and associated marginal basins. These sands are dominantly composed of volcanic-lithic and plagioclase-feldspar grains derived from the Izu-Bonin magmatic arc and intrarift volcanoes. The glass color of volcanic fragments ranges from black (tachylite) to brown to colorless; individual samples usually contain a mixture of glass colors. Two of the forearc sites (792 and 793) are more heterogeneous with respect to glass color than the backarc/Sumisu Rift sites (788, 790, and 791). Site 787 forearc sands are dominantly composed of tachylite grains; their unique composition may be attributed either to winnowing by submarine-canyon currents or to a volcanic island source. There is an increase in the proportions of pumice/colorless glass, felsitic grains, and quartz within sediments of the incipient backarc basin (Sumisu Rift), as compared with the forearc-basin sites.

Chemistry of Pliocene-Pleistocene pumice from the Izu-Bonin Arc

Thick pumice deposits were found in the cored sequences of forearc, arc, and backarc sites of Leg 126 in the Izu-Bonin Arc. These deposits, composed of fragmental rhyolite pumice with the chemical composition of low-alkali tholeiites, are products of arc volcanism. Pumice deposits constitute more than half of the thickness of the sediment fill of the Sumisu Rift, a backarc rift of the Izu-Bonin Arc. They comprise five thick pumiceous beds separated by thin hemipelagic units; as such, they record four major episodes or pulses of explosive, rhyolitic volcanism during the last 0.15 Ma, separated by quiescent intervals that each lasted about 30-60 k.y. The thick pumiceous beds were deposited in the rift mainly by sediment gravity flows during and immediately after the eruption of arc volcanos, which were probably submarine. Initiation of rifting was also preceded in the Pliocene by submarine rhyolitic volcanism, as seen in samples from the top of the eastern rift flank. Thick pumice beds correlative with those in the backarc also occur in the forearc basin to the east.

miR-126 in human cancers : clinical roles and current perspectives

miR-126 has been implicated in the processes of inflammation and angiogenesis. Through these processes, miR-126 is implicated in cancer biology, but its role there has not been well reviewed. The aim of this review is to examine the molecular mechanisms and clinicopathological significance of miR-126 in human cancers. miR-126 was shown to have roles in cancers of the gastrointestinal tract, genital tracts, breast, thyroid, lung and some other cancers. Its expression was suppressed in most of the cancers studied. The molecular mechanisms that are known to cause aberrant expression of miR-126 include alterations in gene sequence, epigenetic modification and alteration of dicer abundance. miR-126 can inhibit progression of some cancers via negative control of proliferation, migration, invasion, and cell survival. In some instances, however, miR-126 supports cancer progression via promotion of blood vessel formation. Downregulation of miR-126 induces cancer cell proliferation, migration, and invasion via targeting specific oncogenes. Also, reduced levels of miR-126 are a significant predictor of poor survival of patients in many cancers. In addition, miR-126 can alter a multitude of cellular mechanisms in cancer pathogenesis via suppressing gene translation of numerous validated targets such as PI3K, KRAS, EGFL7, CRK, ADAM9, HOXA9, IRS-1, SOX-2, SLC7A5 and VEGF. To conclude, miR-126 is commonly down-regulated in cancer, most likely due to its ability to inhibit cancer cell growth, adhesion, migration, and invasion through suppressing a range of important gene targets. Understanding these mechanisms by which miR-126 is involved with cancer pathogenesis will be useful in the development of therapeutic targets for the management of patients with cancer.

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) approximately 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for approximately 2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.

Deregulation of miR-126 expression in colorectal cancer pathogenesis and its clinical significance

In this study, we investigated the expression profiles and clinicopathological significance of miR-126 in large cohort of patients with colorectal cancers as well the cellular repercussions of miR-126 in colon cancer cells along with its targets in-vitro. Down regulation of miR-126 expression was associated with histological subtypes, peri-neural tumour infiltration, microsatellite instability and pathological staging of colorectal cancers (p<0.05). Low miR-126 expression was also associated with poorer survival in patients with colorectal cancer. Analysis of matched tissues from the same patient revealed that approximately 70% of the tested patients had similar levels of expression of miR-126 in primary cancer and cancer metastases in both lymph node and distant metastases. In addition, induced overexpression of miR-126 showed reduced cell proliferation, increased apoptosis and decreased accumulation of cells in the G0-G1 phase of the colon cancer cells. Furthermore, SW480(+miR-126) cells showed reduced BCL-2 and increased P53 protein expression. To conclude, deregulation of miR-126 in colorectal cancer at the tissue and cellular levels as well as its correlation with various clinicopathological parameters confirm the cancer suppressive role of miR-126 in colorectal cancer.