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Changes in modern structural design have created a demand for products which are light but possess high strength. The objective is a reduction in fuel consumption and weight of materials to satisfy both economic and environmental criteria. Cold roll forming has the potential to fulfil this requirement. The bending process is controlled by the shape of the profile machined on the periphery of the rolls. A CNC lathe can machine complicated profiles to a high standard of precision, but the expertise of a numerical control programmer is required. A computer program was developed during this project, using the expert system concept, to calculate tool paths and consequently to expedite the procurement of the machine control tapes whilst removing the need for a skilled programmer. Codifying the expertise of a human and the encapsulation of knowledge within a computer memory, destroys the dependency on highly trained people whose services can be costly, inconsistent and unreliable. A successful cold roll forming operation, where the product is geometrically correct and free from visual defects, is not easy to attain. The geometry of the sheet after travelling through the rolling mill depends on the residual strains generated by the elastic-plastic deformation. Accurate evaluation of the residual strains can provide the basis for predicting the geometry of the section. A study of geometric and material non-linearity, yield criteria, material hardening and stress-strain relationships was undertaken in this research project. The finite element method was chosen to provide a mathematical model of the bending process and, to ensure an efficient manipulation of the large stiffness matrices, the frontal solution was applied. A series of experimental investigations provided data to compare with corresponding values obtained from the theoretical modelling. A computer simulation, capable of predicting that a design will be satisfactory prior to the manufacture of the rolls, would allow effort to be concentrated into devising an optimum design where costs are minimised.

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Ao longo do presente relatório de estágio, é apresentado o trabalho desenvolvido pela estagiária durante o estágio inserido no Ramo de Aprofundamento de Competências Profissionais do Mestrado em Reabilitação Psicomotora. Este decorreu no Centro de Atividades Ocupacionais da Santa Casa da Misericórdia da Madalena, durante 8 meses e meio sendo dirigido à intervenção psicomotora em jovens e adultos com Dificuldades Intelectuais e Desenvolvimentais. A intervenção psicomotora incidiu sobre intervenções individuais/grupais e atividade motora, onde foi promovido o bem-estar, qualidade de vida, funcionalidade e autonomia dos clientes, através da aplicação de atividades lúdico-pedagógicas, de mediatização corporal e terapêuticas. Assim, este documento apresenta o percurso de trabalho da estagiária, desde a sua integração na instituição, passando pela observação e conhecimento dos clientes, avaliação inicial, planeamento do processo terapêutico, avaliação final de resultados e reflexão pessoal acerca de todo o processo de estágio profissionalizante.

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La finalidad de esta propuesta educativa se hace desde la perspectiva de innovación metodológica que parte de procesos cognitivos y afectivos dentro de una simbiosis personal y social. Se desarrolla desde el ámbito de la Facultad de Ciencias de la Educación de la Universidad de Málaga, La metodología pedagógica experimentada sobre Aprendizaje Servicio materializados en dos tipos: aprendizaje anticipador de años atrás en contraste con proyectos del presente en las aulas de la Universidad. El núcleo central se fija en ¿cómo se aprende con el impacto social? La finalidad es resaltar a través de las experiencias los beneficios de dicho aprendizaje donde se potencias las habilidades en el desarrollo del alumno unido al valor formativo del servicio social

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Protein purification plays a crucial role in biotechnology and biomanufacturing, where downstream unit operations account for 40%-80% of the overall costs. To overcome this issue, companies strive to simplify the separation process by reducing the number of steps and replacing expensive separation devices. In this context, commercially available polybutylene terephthalate (PBT) melt-blown nonwoven membranes have been developed as a novel disposable membrane chromatography support. The PBT nonwoven membrane is able to capture products and reduce contaminants by ion exchange chromatography. The PBT nonwoven membrane was modified by grafting a poly(glycidyl methacrylate) (GMA) layer by either photo-induced graft polymerization or heat induced graft polymerization. The epoxy groups of GMA monomer were subsequently converted into cation and anion exchangers by reaction with either sulfonic acid groups or diethylamine (DEA), respectively. Several parameters of the procedure were studied, especially the effect of (i) % weight gain and (ii) ligand density on the static protein binding capacity. Bovine Serum Albumin (BSA) and human Immunoglobulin G (hIgG) were utilized as model proteins in the anion and cation exchange studies. The performance of ion exchange PBT nonwovens by HIG was evaluated under flow conditions. The anion- and cation- exchange HIG PBT nonwovens were evaluated for their ability to selectively adsorb and elute BSA or hIgG from a mixture of proteins. Cation exchange nonwovens were not able to reach a good protein separation, whereas anion exchange HIG nonwovens were able to absorb and elute BSA with very high value of purity and yield, in only one step of purification.