A preference-based semantics for CTD reasoning

In [8] the authors developed a logical system based on the definition of a new non-classical connective ⊗ capturing the notion of reparative obligation. The system proved to be appropriate for handling well-known contrary-to-duty paradoxes but no model-theoretic semantics was presented. In this paper we fill the gap and define a suitable possible-world semantics for the system for which we can prove soundness and completeness. The semantics is a preference-based non-normal one extending and generalizing semantics for classical modal logics.

Teología, 2005, Tomo XLII nº 088 (número completo)

Nota del Director. Nuestra brújula segura -- La crisis de los cuarenta / María Josefina Llach -- Hacia una nueva imaginación. Sobre el laicado y las mujeres en la Iglesia / Virginia R. Azcuy -- Logros y tareas a 40 años de la promulgación de la Constitución Dogmática sobre la Divina Revelación / Claudia Mendoza -- La Constitución Pastoral Gaudium et Spes como “acontecimiento”. Un ingreso desde las “redes” / Marcelo González -- De una cultura ritual a una cultura secular. Críticas a la reforma litúrgica conciliar / Osvaldo Santagada -- El misterio de la Iglesia, pueblo de Dios en comunión / José Carlos Caamaño -- El movimiento ecuménico a 40 años del Concilio Vaticano II / Jorge A. Scampini -- Una articulación del binomio Iglesia universal/ Iglesia particular-local / Antonio Fidalgo -- Nuestra facultad de teología en perspectiva histórica: desde su origen (1915) y hacia su centenario (2015) / Carlos M. Galli -- En torno al misterio de Dios. El pensamiento de Ricardo Ferrara / Carlos A. Castro -- Notas Bibliográficas -- Instrucciones para los colaboradores

Diário da Constituinte [gravação de vídeo] : [programa n. 088]

O Deputado Adhemar de Barros Filho (PDT-SP) defende o fortalecimento econômico dos estados e municípios através de aumento na alíquota do fundo de participação. José Serra (PMDB-SP), relator da Comissão do Sistema Tributário Orçamento e Finanças da Assembleia Nacional Constituinte (ANC), apoia o fortalecimento e mantêm o coeficiente da alíquota do fundo de participação, defendido pela subcomissão. Na Comissão da Soberania e dos Direitos e Garantias do Homem e da Mulher, o Deputado Amaral Neto defende a pena de morte nos crimes hediondos. Maurício Corrêa (PMDB-DF) é totalmente contrário. Populares opinam sobre o assunto. O relatório da Comissão da Ordem Econômica divide os constituintes. Oswaldo Lima Filho (PMDB-PE) achou o anteprojeto fraco. Jonas Pinheiro (PFL-MT) citou alguns aspectos a serem tratados dentro da reforma agrária. Com relação ao uso do solo, a deputada Irma Passoni (PT-SP) defende a fiscalização que não permita o uso depredatório dos minérios brasileiro.

Nutrient Enhanced Coastal Ocean Productivity (NECOP). Data report: CTD and hydrographic data, R/V Pelican cruise, April 3-11, 1993

The Nutrient Enhanced Coastal Ocean Productivity (NECOP) Program is a component of NOAA's Coastal Ocean Program. The central hypothesis of this research is: Anthropogenic nutrient inputs have enhanced coastal ocean productivity with subsequent impacts on coastal ocean water quality, living resource yields, and the global marine carbon cycle. The initial study area for this program is the Mississippi/Atchafalaya River Outflow and adjacent Louisiana shelf region.

Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.

BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. To identify the most highly conserved of the many BRCA1 functions, we screened the evolutionarily distant eukaryote Saccharomyces cerevisiae for mutants that suppressed the G1 checkpoint arrest and lethality induced following heterologous BRCA1 expression. A genome-wide screen in the diploid deletion collection combined with a screen of ionizing radiation sensitive gene deletions identified mutants that permit growth in the presence of BRCA1. These genes delineate a metabolic mRNA pathway that temporally links transcription elongation (SPT4, SPT5, CTK1, DEF1) to nucleopore-mediated mRNA export (ASM4, MLP1, MLP2, NUP2, NUP53, NUP120, NUP133, NUP170, NUP188, POM34) and cytoplasmic mRNA decay at P-bodies (CCR4, DHH1). Strikingly, BRCA1 interacted with the phosphorylated RNA polymerase II (RNAPII) carboxy terminal domain (P-CTD), phosphorylated in the pattern specified by the CTDK-I kinase, to induce DEF1-dependent cleavage and accumulation of a RNAPII fragment containing the P-CTD. Significantly, breast cancer associated BRCT domain defects in BRCA1 that suppressed P-CTD cleavage and lethality in yeast also suppressed the physical interaction of BRCA1 with human SPT5 in breast epithelial cells, thus confirming SPT5 as a relevant target of BRCA1 interaction. Furthermore, enhanced P-CTD cleavage was observed in both yeast and human breast cells following UV-irradiation indicating a conserved eukaryotic damage response. Moreover, P-CTD cleavage in breast epithelial cells was BRCA1-dependent since damage-induced P-CTD cleavage was only observed in the mutant BRCA1 cell line HCC1937 following ectopic expression of wild type BRCA1. Finally, BRCA1, SPT5 and hyperphosphorylated RPB1 form a complex that was rapidly degraded following MMS treatment in wild type but not BRCA1 mutant breast cells. These results extend the mechanistic links between BRCA1 and transcriptional consequences in response to DNA damage and suggest an important role for RNAPII P-CTD cleavage in BRCA1-mediated cancer suppression.