A preference-based semantics for CTD reasoning

In [8] the authors developed a logical system based on the definition of a new non-classical connective ⊗ capturing the notion of reparative obligation. The system proved to be appropriate for handling well-known contrary-to-duty paradoxes but no model-theoretic semantics was presented. In this paper we fill the gap and define a suitable possible-world semantics for the system for which we can prove soundness and completeness. The semantics is a preference-based non-normal one extending and generalizing semantics for classical modal logics.

Teología, 2004, Tomo XLI nº 084 (número completo)

Nota del Director. Advertencia sobre los números de tomos -- La “gracia del invitado”. Hacia una hermenéutica teológica del camino de Emaús – Hitos de una dogmática fundamental intercultural / Margit Eckholt -- La identidad específica del catequista / Víctor Manuel Fernández -- Nuevos escenarios y líneas emergentes en la teología católica contemporánea / Marcelo González – Navega mar adentro: expresión y proyección del reciente itinerario teológico-pastoral de la Iglesia en Argentina / Gerardo Daniel Ramos scj -- La fórmula cristológica una persona en dos naturalezas en el contexto de los sermones de San León Magno / Hernán Martín Giudice -- Algunas reflexiones en torno a la problemática “cerebro-mente” / Juan Demetrio Jiménez -- La integración de la exégesis en la reflexión teológica / Luis Heriberto Rivas -- Luis Heriberto Rivas: un sembrador de la Palabra / Carlos M. Galli -- Laudatio / Julio Raúl Méndez -- Notas bibliográficas

Diário da Constituinte [gravação de vídeo] : [programa n. 084]

A Gráfica do Senado Federal está funcionando 24 horas. Agaciel Maia, diretor do Centro Gráfico, relata que a demanda aumentou em decorrência da produção do Diário da Assembleia Nacional Constituinte (ANC) e do Jornal da Constituinte. Os relatores Artur da Távola (PMDB-RJ) e Severo Gomes (PMDB-SP) fizeram um balanço dos seus anteprojetos. O Distrito Federal ganha automonia política. O senador Pompeu de Souza (PMDB-DF) acredita que o relator, ao coincidir as eleições presidenciais com a de governador distrital, pensou que a probabilidade dos candidatos serem do mesmo partido seria grande. A deputada Marcia Kubitscheck (PMDB-DF) fala que a eleição conjunta dará maior destaque à Brasília. O deputado Jofran Frejat (PFL-DF) disse que a única pendência é o prazo do mandato de governador.

Nutrient Enhanced Coastal Ocean Productivity (NECOP). Data report: CTD and hydrographic data, R/V Pelican cruise, April 3-11, 1993

The Nutrient Enhanced Coastal Ocean Productivity (NECOP) Program is a component of NOAA's Coastal Ocean Program. The central hypothesis of this research is: Anthropogenic nutrient inputs have enhanced coastal ocean productivity with subsequent impacts on coastal ocean water quality, living resource yields, and the global marine carbon cycle. The initial study area for this program is the Mississippi/Atchafalaya River Outflow and adjacent Louisiana shelf region.

Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.

BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. To identify the most highly conserved of the many BRCA1 functions, we screened the evolutionarily distant eukaryote Saccharomyces cerevisiae for mutants that suppressed the G1 checkpoint arrest and lethality induced following heterologous BRCA1 expression. A genome-wide screen in the diploid deletion collection combined with a screen of ionizing radiation sensitive gene deletions identified mutants that permit growth in the presence of BRCA1. These genes delineate a metabolic mRNA pathway that temporally links transcription elongation (SPT4, SPT5, CTK1, DEF1) to nucleopore-mediated mRNA export (ASM4, MLP1, MLP2, NUP2, NUP53, NUP120, NUP133, NUP170, NUP188, POM34) and cytoplasmic mRNA decay at P-bodies (CCR4, DHH1). Strikingly, BRCA1 interacted with the phosphorylated RNA polymerase II (RNAPII) carboxy terminal domain (P-CTD), phosphorylated in the pattern specified by the CTDK-I kinase, to induce DEF1-dependent cleavage and accumulation of a RNAPII fragment containing the P-CTD. Significantly, breast cancer associated BRCT domain defects in BRCA1 that suppressed P-CTD cleavage and lethality in yeast also suppressed the physical interaction of BRCA1 with human SPT5 in breast epithelial cells, thus confirming SPT5 as a relevant target of BRCA1 interaction. Furthermore, enhanced P-CTD cleavage was observed in both yeast and human breast cells following UV-irradiation indicating a conserved eukaryotic damage response. Moreover, P-CTD cleavage in breast epithelial cells was BRCA1-dependent since damage-induced P-CTD cleavage was only observed in the mutant BRCA1 cell line HCC1937 following ectopic expression of wild type BRCA1. Finally, BRCA1, SPT5 and hyperphosphorylated RPB1 form a complex that was rapidly degraded following MMS treatment in wild type but not BRCA1 mutant breast cells. These results extend the mechanistic links between BRCA1 and transcriptional consequences in response to DNA damage and suggest an important role for RNAPII P-CTD cleavage in BRCA1-mediated cancer suppression.

Resolución No. 084: Por la cual se resuelve un recurso de reposición y en subsidio de apelación

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Phosphorylation du CTD de l'ARN polymérase II et impact de l'histone H2A.Z sur le positionnement des nucléosomes chez S. cerevisiae

La phosphorylation du domaine C-terminal de l’ARN polymérase II permet à ce complexe protéique d’exécuter la transcription des gènes, en plus de coupler à la transcription des événements moléculaires comme la maturation des ARNm. Mes résultats montrent que même si cette phosphorylation suit un patron similaire à l’ensemble des gènes, il existe des exceptions pouvant être dues à des mécanismes alternatifs de phosphorylation du CTD. Le présent ouvrage s’intéresse également au rôle qu’occupe la variante d’histone H2A.Z dans l’organisation de la chromatine. Des études précédentes on montré que le positionnement de certains nucléosomes le long de l’ADN serait influencé par H2A.Z et aurait une influence sur la capacité de transcrire les gènes. Par une approche génomique utilisant les puces à ADN, j’ai cartographié l’impact de la délétion de H2A.Z sur la structure des nucléosomes. Enfin, des résultats intéressants sur la dynamique d’incorporation de H2A.Z à la chromatine ont été obtenus.

The Azores Current System and the Canary Current from CTD and ADCP data

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