1000 resultados para 08171825 CTD-039
Resumo:
In [8] the authors developed a logical system based on the definition of a new non-classical connective ⊗ capturing the notion of reparative obligation. The system proved to be appropriate for handling well-known contrary-to-duty paradoxes but no model-theoretic semantics was presented. In this paper we fill the gap and define a suitable possible-world semantics for the system for which we can prove soundness and completeness. The semantics is a preference-based non-normal one extending and generalizing semantics for classical modal logics.
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Matrimonio indisoluble en un mundo inestable: incertidumbres y certezas. Análisis de algunas opiniones vertidas en el planteo actual del problema de la pastoral de divorciados / Juan Carlos Meinville -- Apuntes bíblicos sobre la templanza / José María Arancibia -- “El hijo pródigo”: un auto-sacramental cuzqueño del siglo XVII / Francisco Jorge Veissmann -- Los seminarios y la formación de los eclesiásticos en el período de la confederación 1852-1861 / Néstor Tomás Auza -- Pedro y Pablo. Dos publicaciones recientes. Comentario bibliográfico / Jorge Mejía -- Notas bibliográficas -- Libros recibidos
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Relatores vão ao PRODASEN usar computadores com banco de dados da Constituição. José Jorge (PFL-PE), relator da Subcomissão do Poder Legislativo da Assembleia Nacional Constituinte (ANC), fala sobre a conclusão dos relatórios. Mário Lima (PMDB-BA), relator da Subcomissão dos Diretos dos Trabalhadores e Servidores Públicos, fala dos direitos de greve dos trabalhadores, estabilidade de emprego e jornada de trabalho. Ricardo Fiuza (PFL-PR) mostra um quadro organizacional que associa propostas semelhantes. Plínio Arruda (PT-SP) comenta sobre os direitos e deveres na nova Constituição. Siqueira Campos (PDC-GO), relator da Subcomissão dos Estados, fala da redivisão territorial do Brasil e do fortalecimento da federação com equilíbrio entre os Estados. Apresentado parecer na Subcomissão dos Negros, Populações Indígenas, Pessoas Deficientes e Minorias que trata das garantias das minorias. Benedita da Silva (PT-RJ) afirma que discriminação é crime, pede isonomia aos negros e povos indígenas. José Fogaça(PMDB-RS), relator da Subcomissão do Poder Executivo, diz que a Subcomissão entrou em consenso quanto a eleição direta e a existência do primeiro-ministro.
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The Nutrient Enhanced Coastal Ocean Productivity (NECOP) Program is a component of NOAA's Coastal Ocean Program. The central hypothesis of this research is: Anthropogenic nutrient inputs have enhanced coastal ocean productivity with subsequent impacts on coastal ocean water quality, living resource yields, and the global marine carbon cycle. The initial study area for this program is the Mississippi/Atchafalaya River Outflow and adjacent Louisiana shelf region.
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BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. To identify the most highly conserved of the many BRCA1 functions, we screened the evolutionarily distant eukaryote Saccharomyces cerevisiae for mutants that suppressed the G1 checkpoint arrest and lethality induced following heterologous BRCA1 expression. A genome-wide screen in the diploid deletion collection combined with a screen of ionizing radiation sensitive gene deletions identified mutants that permit growth in the presence of BRCA1. These genes delineate a metabolic mRNA pathway that temporally links transcription elongation (SPT4, SPT5, CTK1, DEF1) to nucleopore-mediated mRNA export (ASM4, MLP1, MLP2, NUP2, NUP53, NUP120, NUP133, NUP170, NUP188, POM34) and cytoplasmic mRNA decay at P-bodies (CCR4, DHH1). Strikingly, BRCA1 interacted with the phosphorylated RNA polymerase II (RNAPII) carboxy terminal domain (P-CTD), phosphorylated in the pattern specified by the CTDK-I kinase, to induce DEF1-dependent cleavage and accumulation of a RNAPII fragment containing the P-CTD. Significantly, breast cancer associated BRCT domain defects in BRCA1 that suppressed P-CTD cleavage and lethality in yeast also suppressed the physical interaction of BRCA1 with human SPT5 in breast epithelial cells, thus confirming SPT5 as a relevant target of BRCA1 interaction. Furthermore, enhanced P-CTD cleavage was observed in both yeast and human breast cells following UV-irradiation indicating a conserved eukaryotic damage response. Moreover, P-CTD cleavage in breast epithelial cells was BRCA1-dependent since damage-induced P-CTD cleavage was only observed in the mutant BRCA1 cell line HCC1937 following ectopic expression of wild type BRCA1. Finally, BRCA1, SPT5 and hyperphosphorylated RPB1 form a complex that was rapidly degraded following MMS treatment in wild type but not BRCA1 mutant breast cells. These results extend the mechanistic links between BRCA1 and transcriptional consequences in response to DNA damage and suggest an important role for RNAPII P-CTD cleavage in BRCA1-mediated cancer suppression.
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Servicios registrales
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La phosphorylation du domaine C-terminal de l’ARN polymérase II permet à ce complexe protéique d’exécuter la transcription des gènes, en plus de coupler à la transcription des événements moléculaires comme la maturation des ARNm. Mes résultats montrent que même si cette phosphorylation suit un patron similaire à l’ensemble des gènes, il existe des exceptions pouvant être dues à des mécanismes alternatifs de phosphorylation du CTD. Le présent ouvrage s’intéresse également au rôle qu’occupe la variante d’histone H2A.Z dans l’organisation de la chromatine. Des études précédentes on montré que le positionnement de certains nucléosomes le long de l’ADN serait influencé par H2A.Z et aurait une influence sur la capacité de transcrire les gènes. Par une approche génomique utilisant les puces à ADN, j’ai cartographié l’impact de la délétion de H2A.Z sur la structure des nucléosomes. Enfin, des résultats intéressants sur la dynamique d’incorporation de H2A.Z à la chromatine ont été obtenus.
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Se han eliminado páginas en blanco