1000 resultados para 08151222 CTD-027
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This series of research vignettes is aimed at sharing current and interesting research findings from our team of international Entrepreneurship researchers. This vignette, written by Professor Per Davidsson, examines psychological research on the role of personality in entrepreneurial endeavours.
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In Australian Prudential Regulation Authority v Rural and General Insurance Let [2004] FCA 933, Gyles J considered what he described as "a novel question", namely, whether taking steps to prepare to give oral evidence when subpoenaed to attend for that purpose, including the obtaining of legal advice and assistance, could be recovered by the witness under O 27 r 11 of the Federal Court Rules
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In [8] the authors developed a logical system based on the definition of a new non-classical connective ⊗ capturing the notion of reparative obligation. The system proved to be appropriate for handling well-known contrary-to-duty paradoxes but no model-theoretic semantics was presented. In this paper we fill the gap and define a suitable possible-world semantics for the system for which we can prove soundness and completeness. The semantics is a preference-based non-normal one extending and generalizing semantics for classical modal logics.
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San Cipriano y el Donatismo, en la polémica antidonatista de san Agustín. Estudio histórico-patrístico / Rubén D. García -- La Iglesia y la existencia cristiana en la teología de San Buenaventura. II° parte / José Rovai -- Renovación de la Iglesia Ortodoxa Rusa a principios de este siglo / Domingo Krpan -- Pueblo, religión del pueblo e Iglesia / Lucio Gera -- El plan de la Epístola a los Gálatas / Luis H. Rivas -- Sagrada Congregación para la Educación Católica: La formación teológica de los futuros sacerdotes -- Notas bibliográficas
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Programa especial do Dia do Trabalhador. Informa o perfil profissional dos constituintes. O Senador Edison Lobão (PFL-MA) espera que os parlamentares trabalhem em benefício do povo brasileiro. A Deputada Cristina Tavares (PSDB-PE) deseja que os constituintes saibam ouvir os anseios da sociedade. O Deputado Paulo Paim (PT-RS) quer que as reivindicações dos brasileiros sejam atendidas. Populares falam o que esperam da nova Constituição. A Subcomissão dos Direitos dos Trabalhadores e Servidores Públicos da Assembleia Nacional Constituinte (ANC) recebe dos constituintes e entidades de classe mais de 500 reivindicações, como o direito de greve e estabilidade no emprego. O Deputado Geraldo Campos (PSDB-DF) disse que as propostas têm recebido o apoio da maioria dos constituintes. O Deputado Augusto de Carvalho (PCB-DF) falou que o momento é de união e fortalecimento. A Deputada Moema São Thiago (PSDB-CE) disse que na Constituição será assegurado o processo de redemocratização. O Deputado Luiz Inácio Lula da Silva (PT-SP) apoia a classe trabalhadora que deve estar organizada para pressionar o Congresso e a Constituinte para garantir direitos efetivos.
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The Nutrient Enhanced Coastal Ocean Productivity (NECOP) Program is a component of NOAA's Coastal Ocean Program. The central hypothesis of this research is: Anthropogenic nutrient inputs have enhanced coastal ocean productivity with subsequent impacts on coastal ocean water quality, living resource yields, and the global marine carbon cycle. The initial study area for this program is the Mississippi/Atchafalaya River Outflow and adjacent Louisiana shelf region.
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BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. To identify the most highly conserved of the many BRCA1 functions, we screened the evolutionarily distant eukaryote Saccharomyces cerevisiae for mutants that suppressed the G1 checkpoint arrest and lethality induced following heterologous BRCA1 expression. A genome-wide screen in the diploid deletion collection combined with a screen of ionizing radiation sensitive gene deletions identified mutants that permit growth in the presence of BRCA1. These genes delineate a metabolic mRNA pathway that temporally links transcription elongation (SPT4, SPT5, CTK1, DEF1) to nucleopore-mediated mRNA export (ASM4, MLP1, MLP2, NUP2, NUP53, NUP120, NUP133, NUP170, NUP188, POM34) and cytoplasmic mRNA decay at P-bodies (CCR4, DHH1). Strikingly, BRCA1 interacted with the phosphorylated RNA polymerase II (RNAPII) carboxy terminal domain (P-CTD), phosphorylated in the pattern specified by the CTDK-I kinase, to induce DEF1-dependent cleavage and accumulation of a RNAPII fragment containing the P-CTD. Significantly, breast cancer associated BRCT domain defects in BRCA1 that suppressed P-CTD cleavage and lethality in yeast also suppressed the physical interaction of BRCA1 with human SPT5 in breast epithelial cells, thus confirming SPT5 as a relevant target of BRCA1 interaction. Furthermore, enhanced P-CTD cleavage was observed in both yeast and human breast cells following UV-irradiation indicating a conserved eukaryotic damage response. Moreover, P-CTD cleavage in breast epithelial cells was BRCA1-dependent since damage-induced P-CTD cleavage was only observed in the mutant BRCA1 cell line HCC1937 following ectopic expression of wild type BRCA1. Finally, BRCA1, SPT5 and hyperphosphorylated RPB1 form a complex that was rapidly degraded following MMS treatment in wild type but not BRCA1 mutant breast cells. These results extend the mechanistic links between BRCA1 and transcriptional consequences in response to DNA damage and suggest an important role for RNAPII P-CTD cleavage in BRCA1-mediated cancer suppression.
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