Relative prices in Latin America in periods of low inflation and structural change

Includes bibliography

The competitive real exchange-rate regime, inflation and monetary policy

Includes bibliography

Inflation targeting works well in Latin America

Includes bibliography

Financial market reaction to central bank monetary policy communications under an inflation- targeting regime: the case of Brazil

Includes bibliography

Inflation and stabilization policies

Senala algunos de los problemas destacados en el analisis de las causas y consecuencias de la inflacion y el diseno de politicas de estabilizacion; y examina un caso particular, el Plan Austral aplicado en Argentina desde mediados de 1985.

An Integrative Genomic and Transcriptomic Analysis Reveals Potential Targets Associated with Cell Proliferation in Uterine Leiomyomas

Background: Uterine Leiomyomas (ULs) are the most common benign tumours affecting women of reproductive age. ULs represent a major problem in public health, as they are the main indication for hysterectomy. Approximately 40-50% of ULs have non-random cytogenetic abnormalities, and half of ULs may have copy number alterations (CNAs). Gene expression microarrays studies have demonstrated that cell proliferation genes act in response to growth factors and steroids. However, only a few genes mapping to CNAs regions were found to be associated with ULs. Methodology: We applied an integrative analysis using genomic and transcriptomic data to identify the pathways and molecular markers associated with ULs. Fifty-one fresh frozen specimens were evaluated by array CGH (JISTIC) and gene expression microarrays (SAM). The CONEXIC algorithm was applied to integrate the data. Principal Findings: The integrated analysis identified the top 30 significant genes (P<0.01), which comprised genes associated with cancer, whereas the protein-protein interaction analysis indicated a strong association between FANCA and BRCA1. Functional in silico analysis revealed target molecules for drugs involved in cell proliferation, including FGFR1 and IGFBP5. Transcriptional and protein analyses showed that FGFR1 (P = 0.006 and P<0.01, respectively) and IGFBP5 (P = 0.0002 and P = 0.006, respectively) were up-regulated in the tumours when compared with the adjacent normal myometrium. Conclusions: The integrative genomic and transcriptomic approach indicated that FGFR1 and IGFBP5 amplification, as well as the consequent up-regulation of the protein products, plays an important role in the aetiology of ULs and thus provides data for potential drug therapies development to target genes associated with cellular proliferation in ULs. © 2013 Cirilo et al.

Resolución 13: Inflación = Resolution 13: Inflation = Résolution 13: Inflation

El símbolo E/840/Rev.1 corresponde a la edición bilingüe inglés/francés publicada en 1953

Anti-Candida targets and cytotoxicity of casuarinin isolated from Plinia cauliflora leaves in a bioactivity-guided study

In addition to the bio-guided investigation of the antifungal activity of Plinia cauliflora leaves against different Candida species, the major aim of the present study was the search for targets on the fungal cell. The most active antifungal fraction was purified by chromatography and characterized by NMR and mass spectrometry. The antifungal activity was evaluated against five Candida strains according to referenced guidelines. Cytotoxicity against fibroblast cells was determined. The likely targets of Candida albicans cells were assessed through interactions with ergosterol and cell wall composition, porosity and architecture. The chemical major component within the most active antifungal fraction of P. cauliflora leaves identified was the hydrolysable tannin casuarinin. The cytotoxic concentration was higher than the antifungal one. The first indication of plant target on cellular integrity was suggested by the antifungal activity ameliorated when using an osmotic support. The most important target for the tannin fraction studied was suggested by ultrastructural analysis of yeast cell walls revealing a denser mannan outer layer and wall porosity reduced. It is possible to imply that P. cauliflora targeted the C. albicans cell wall inducing some changes in the architecture, notably the outer glycoprotein layer, affecting the cell wall porosity without alteration of the polysaccharide or protein level. © 2013 by the authors.

Chameleonic inflation

We attempt to incorporate inflation into a string theory realization of the chameleon mechanism. Previously, it was found that the volume modulus, stabilized by the supersymmetric potential used by Kachru, Kallosh, Linde and Trivedi (KKLT) and with the right choice of parameters, can generically work as a chameleon. In this paper, we ask whether inflation can be realized in the same model. We find that we need a large extra dimensions set-up, as well as a semi-phenomenological deformation of the Kähler potential in the quantum region. We also find that an additional KKLT term is required so that there are now two pieces to the potential, one which drives inflation in the early universe, and one which is responsible for chameleon screening at late times. These two pieces of the potential are separated by a large flat desert in field space. The scalar field must dynamically traverse this desert between the end of inflation and today, and we find that this can indeed occur under the right conditions. © 2013 SISSA, Trieste, Italy.

Inflation and growth = Inflación y crecimiento: Resumen de la experiencia en América Latina

Includes bibliography

ECLAC Notes Nº 30

The Economy of Latin America and the Caribbean Posts Modest Recovery Changes in Latin America and Caribbean Countries' Economic Policy Opinion by Alicia Bárcena, ECLAC's Deputy Executive Secretay. Financial Innovation and the Millennium Targets Highlights. Export Competitiveness and the Real Exchange Rate Indicators Inflation Declines and Employment Rises Recent titles and calendar of events

Mexico: Combining monthly inflation predictions from surveys

We examine the problem of combining Mexican inflation predictions or projections provided by a biweekly survey of professional forecasters. Consumer price inflation in Mexico is measured twice a month. We consider several combining methods and advocate the use of dimension reduction techniques whose performance is compared with different benchmark methods, including the simplest average prediction. Missing values in the database are imputed by two different databased methods. The results obtained are basically robust to the choice of the imputation method. A preliminary analysis of the data was based on its panel data structure and showed the potential usefulness of using dimension reduction techniques to combine the experts' predictions. The main findings are: the first monthly predictions are best combined by way of the first principal component of the predictions available; the best second monthly prediction is obtained by calculating the median prediction and is more accurate than the first one.