A-7 Statistical Report On FIP Applications And Cases Discontinued, January 2005

A-7 Statistical Report On FIP Applications And Cases Discontinued

A-1 Monthly Public Assistance Statistical Report Family Investment Program, February 2005

Monthly Public Assistance Statistical Report Family Investment Program

A-7 Statistical Report On FIP Applications And Cases Discontinued, February 2005

Statistical Report On FIP Applications And Cases Discontinued

A-1 Monthly Public Assistance Statistical Report Family Investment Program, March 2005

A-1 Monthly Public Assistance Statistical Report Family Investment Program

A-7 Statistical Report On FIP Applications And Cases Discontinued, March 2005

A-7 Statistical Report On FIP Applications And Cases Discontinued

A-1 Monthly Public Assistance Statistical Report Family Investment Program, April 2005

Monthly Public Assistance Statistical Report Family Investment Program

Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations.

Blood pressure (BP) is a heritable, quantitative trait with intraindividual variability and susceptibility to measurement error. Genetic studies of BP generally use single-visit measurements and thus cannot remove variability occurring over months or years. We leveraged the idea that averaging BP measured across time would improve phenotypic accuracy and thereby increase statistical power to detect genetic associations. We studied systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP) averaged over multiple years in 46,629 individuals of European ancestry. We identified 39 trait-variant associations across 19 independent loci (p < 5 × 10(-8)); five associations (in four loci) uniquely identified by our LTA analyses included those of SBP and MAP at 2p23 (rs1275988, near KCNK3), DBP at 2q11.2 (rs7599598, in FER1L5), and PP at 6p21 (rs10948071, near CRIP3) and 7p13 (rs2949837, near IGFBP3). Replication analyses conducted in cohorts with single-visit BP data showed positive replication of associations and a nominal association (p < 0.05). We estimated a 20% gain in statistical power with long-term average (LTA) as compared to single-visit BP association studies. Using LTA analysis, we identified genetic loci influencing BP. LTA might be one way of increasing the power of genetic associations for continuous traits in extant samples for other phenotypes that are measured serially over time.

A-1 Monthly Public Assistance Statistical Report Family Investment Program, May 2005

Monthly Public Assistance Statistical Report Family Investment Program

A-7 Statistical Report On FIP Applications And Cases Discontinued April 2005

Statistical Report On FIP Applications And Cases Discontinued

A-7 Statistical Report On FIP Applications And Cases Discontinued, May 2005

Statistical Report On FIP Applications And Cases Discontinued

Splitting statistical potentials into meaningful scoring functions: testing the prediction of near-native structures from decoy conformations

Background: Recent advances on high-throughput technologies have produced a vast amount of protein sequences, while the number of high-resolution structures has seen a limited increase. This has impelled the production of many strategies to built protein structures from its sequence, generating a considerable amount of alternative models. The selection of the closest model to the native conformation has thus become crucial for structure prediction. Several methods have been developed to score protein models by energies, knowledge-based potentials and combination of both.Results: Here, we present and demonstrate a theory to split the knowledge-based potentials in scoring terms biologically meaningful and to combine them in new scores to predict near-native structures. Our strategy allows circumventing the problem of defining the reference state. In this approach we give the proof for a simple and linear application that can be further improved by optimizing the combination of Zscores. Using the simplest composite score () we obtained predictions similar to state-of-the-art methods. Besides, our approach has the advantage of identifying the most relevant terms involved in the stability of the protein structure. Finally, we also use the composite Zscores to assess the conformation of models and to detect local errors.Conclusion: We have introduced a method to split knowledge-based potentials and to solve the problem of defining a reference state. The new scores have detected near-native structures as accurately as state-of-art methods and have been successful to identify wrongly modeled regions of many near-native conformations.

A-1 Monthly Public Assistance Statistical Report Family Investment Program, June 2005

A-1 Monthly Public Assistance Statistical Report Family Investment Program, June 2005

A-7 Statistical Report On FIP Applications And Cases Discontinued, June 2005

A-7 Statistical Report On FIP Applications And Cases Discontinued, June 2005

A-1 Monthly Public Assistance Statistical Report Family Investment Program, July 2005

A-1 Monthly Public Assistance Statistical Report Family Investment Program, July 2005

A-7 Statistical Report On FIP Applications And Cases Discontinued, July 2005

A-7 Statistical Report On FIP Applications And Cases Discontinued, July 2005