1000 resultados para Special matrices
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Report on a special investigation of the Mills County Treasurer’s Office for the period January 1, 2005 through March 31, 2011
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Report on a special investigation of the City of Davis City for the period October 1, 2006 through November 26, 2011
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Report on a special investigation of the Amana Colonies Land Use District for the period May 21, 2007 through March 31, 2011
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Report on a special investigation of the City of Callender for the period January 1, 2009 through January 3, 2012
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Report on a special investigation of the Benton County Conservation Department for the period June 1, 2010 through November 7, 2011
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Report on a special investigation of the City of Blencoe for the period January 1, 2008 through September 30, 2011
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The safe and responsible development of engineered nanomaterials (ENM), nanotechnology-based materials and products, together with the definition of regulatory measures and implementation of "nano"-legislation in Europe require a widely supported scientific basis and sufficient high quality data upon which to base decisions. At the very core of such a scientific basis is a general agreement on key issues related to risk assessment of ENMs which encompass the key parameters to characterise ENMs, appropriate methods of analysis and best approach to express the effect of ENMs in widely accepted dose response toxicity tests. The following major conclusions were drawn: Due to high batch variability of ENMs characteristics of commercially available and to a lesser degree laboratory made ENMs it is not possible to make general statements regarding the toxicity resulting from exposure to ENMs. 1) Concomitant with using the OECD priority list of ENMs, other criteria for selection of ENMs like relevance for mechanistic (scientific) studies or risk assessment-based studies, widespread availability (and thus high expected volumes of use) or consumer concern (route of consumer exposure depending on application) could be helpful. The OECD priority list is focussing on validity of OECD tests. Therefore source material will be first in scope for testing. However for risk assessment it is much more relevant to have toxicity data from material as present in products/matrices to which men and environment are be exposed. 2) For most, if not all characteristics of ENMs, standardized methods analytical methods, though not necessarily validated, are available. Generally these methods are only able to determine one single characteristic and some of them can be rather expensive. Practically, it is currently not feasible to fully characterise ENMs. Many techniques that are available to measure the same nanomaterial characteristic produce contrasting results (e.g. reported sizes of ENMs). It was recommended that at least two complementary techniques should be employed to determine a metric of ENMs. The first great challenge is to prioritise metrics which are relevant in the assessment of biological dose response relations and to develop analytical methods for characterising ENMs in biological matrices. It was generally agreed that one metric is not sufficient to describe fully ENMs. 3) Characterisation of ENMs in biological matrices starts with sample preparation. It was concluded that there currently is no standard approach/protocol for sample preparation to control agglomeration/aggregation and (re)dispersion. It was recommended harmonization should be initiated and that exchange of protocols should take place. The precise methods used to disperse ENMs should be specifically, yet succinctly described within the experimental section of a publication. 4) ENMs need to be characterised in the matrix as it is presented to the test system (in vitro/ in vivo). 5) Alternative approaches (e.g. biological or in silico systems) for the characterisation of ENMS are simply not possible with the current knowledge. Contributors: Iseult Lynch, Hans Marvin, Kenneth Dawson, Markus Berges, Diane Braguer, Hugh J. Byrne, Alan Casey, Gordon Chambers, Martin Clift, Giuliano Elia1, Teresa F. Fernandes, Lise Fjellsbø, Peter Hatto, Lucienne Juillerat, Christoph Klein, Wolfgang Kreyling, Carmen Nickel1, and Vicki Stone.
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Report on a special investigation of the New Hampton Municipal Light Plant for the period January 1, 2001 through May 31, 2012
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Report on a special investigation of the University of Iowa Hospital and Clinics, Department of Orthopaedics and Rehabilitation, for the period December 1, 2002 through January 31, 2012
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Report on a special investigation of the Southwest Iowa Transit Agency for the period July 1, 2011 through June 30, 2012
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Report on a special investigation of the City of Buffalo for the period September 25, 2008 through September 30, 2010
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This report is submitted by the Iowa Department of Transportation, Motor Vehicle Division in compliance with Administrative Rule 761-401.18(3) Discontinuance. This rule requires the department to report to the legislature if 250 paid applications for any of the special registration plates subject to this rule are not submitted within one year after the date the department makes the plate available for application in order to request authority to discontinue any of the special registration plates established under Iowa Code section 321.34, new subsections 20C, 25 and 26 as amended by 2011 Iowa Acts, House File 651, section 2.
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Report on a special investigation of the Adair County Engineer’s Office for the period December 5, 2001 through December 31, 2011
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Report on a special investigation of the City of Masonville for the period of March 18, 2002 to November 30, 2011
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Report on a special investigation of the Coggon Municipal Light Plant for the period July 1, 2004 through August 27, 2012
