Mapeamento geológico-geotécnico pelo método de detalhamento progressivo: aplicação no planejamento e gestão de obras rodoviárias

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Potencial de ocorrência de avarias ambientais em bacias hidrográficas com ocupação rural mediante análise morfométrica

The understanding of the geo-morphological characteristics allows the identification of flood areas and instability slopes among others important features for land use planning. The study of the hydrological net and the analysis of morphometric parameters help in the geomorphologic characterization, providing specific physics indicators that quantify the risks for environmental damages. The present work used Geographic Information Systems (GIS) and carried out the morphometric analysis of two watersheds in the Alto Rio Sorocaba, municipality of Ibiuna (SP). Using digitalized topographic bases in the scale 1:50,000, the main morphometric parameters were extracted and the Digital Elevation Model (DEM) was obtained. Hence the slope, ground illumination, hill orientation and relief feature maps were elaborated. The characteristics for the two watersheds were quite similar, both have low risks for floods and landslides. Therefore, the concave feature is the predominant hill shape for both watersheds. The morphometric parameters directly related to the river density of the watersheds showed some differences, because the Sorocabuçú watershed presents higher value, resulting in a higher level of relief development. Thus, with this characterization it is possible to provide subsidies for environmental planning actions to the area.

Análise de uso da terra e sua interferência em enchentes na região do Córrego Lavapés, Rio Claro (SP)

The development of cities is initially nearby rivers and with the intensification of the urbanization process occurs the soil sealing, leading to an increased level of water runoff, and, consequently, in a greater number of floods. The main goal of this study is to verify the interference of land occupation in the floods of the Lavapés Stream basin, Rio Claro (SP), in five temporal series, 1962, 1972, 1988, 1995 and 2014. The characterizations of land use were made from photo-interpretation and, thus, were produced thematic maps on scale 1: 20.000. The description of the Soil Conservation Service, 2007 was the basis for the classification of land use, thus achieving the CN parameter (Curve Number) used in hydrologic modeling done in IPHS1 program. The results indicate that soil sealing associated with the growth of the city of Rio Claro are responsible for increasing of the discharge in the Lavapés Stream basin and floods in this watershed

Acompanhamento da dinâmica do uso do solo em uma bacia hidrográfica no Município de Botucatu (SP) por meio de geotecnologia

The increasing expansion of agricultural activities, without considering the potential and limitations of soils is a potential source of environmental degradation. Thus, the present study assessed the variation of use and occupation in 49 years, between 1962 and 2011 scenarios of watershed of São Caetano - Botucatu (SP). geoprocessing techniques were used in this study. In a Geographic Information System (GIS) - IDRISI – it was integrated information from IBGE digital cards, scale 1:50,000, plus aerial photographs (1962) and satellite images LANDSAT - 5 (2011). In the study area, we can view the progress of the urban area, which in 1962 was not present in the watershed. In 2011, the urban area occupied 21.37% of the total area. Even with this breakthrough occurring in the period of 49 years, there was an increase in the area of natural vegetation, which once occupied only 12.33% of the area (1962), and in 2011 represents 25% of the total area of the watershed, showing an increase in awareness on the importance of preserving nature. Thus, we can conclude that the analysis tools based on GIS enabled us to analyze variations in space and time and to propose alternatives to the correct use and occupation of land.

Análise do conflito do uso e ocupação da terra em área de preservação permanente através do SIG

This study aimed to map the classes of use and occupation and their conflicts in Areas of Permanent Preservation (APPs) in the basin of Ribeirão São Pedro - Botucatu (SP) with the use of remote sensing techniques - image obtained by satellite 2011 - and the use of GIS. For this, we used the GIS techniques, and the integration of information held in the Geographic Information System (GIS) - IDRISI, coupled with the use of digital maps, published by the Brazilian Institute of Geography and Statistics - IBGE, scale 1: 50,000 and satellite images LANDSAT - 5 (2011) sensor TM (Thematic Mapper) with spatial resolution of 30 x 30 meters, provided by the National Institute for Space Research (INPE) .The Geographic Information System (GIS) was used IDRISI Selva and software, CartaLinx. This work had as legal support environmental legislation, specifically, the Federal Law 12.651 / 12. Thus, the study of the watershed becomes an important tool to understand its dynamics in relation to the use and occupation of their area and to characterize their environmental problems and taking as legal counsel to the preservation and conservation of the land to support environmental legislation.

Caracterização de conflitos de uso do solo em apps na bacia hidrográfica do córrego barra seca (pederneiras/sp)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Análises celulares e moleculares dos efeitos do peptídeo vasoativo angiotensina-(1-7) no processo tumoral pulmonar e a atuação do microrna 21-5P

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Mapeamento geológico-geotécnico por meio de análise integrada no Parque Estadual do Juquery - Franco da Rocha-SP

Pós-graduação em Geociências e Meio Ambiente - IGCE

Experimental Adhesives with Different Hydrophilicity: Microshear Test in after 1, 7, and 90 Days' Storage

Purpose: To assess the microshear bond strength of 3 experimental adhesives with different degrees of hydrophilicity after 1, 7 and 90 days of storage. Materials and Methods: The bonding effectiveness of three experimental two-step etch-and-rinse adhesives (bis-GMA, bis-EMA/bis-GMA, polybutadiene [C6H12]) and one commercial adhesive (Single Bond) to sound hydrated dentin was determined using the nnicroshear test with delimitation of the adhesive area after 1, 7, and 90 days of storage in water at 37 degrees C. Two-way ANOVA was performed at the 0.05 probability level. The fractures were classified as adhesive, cohesive in dentin, cohesive in resin, and mixed. Results: The experimental adhesives showed values in the range of 11.31 to 12.96 MPa, with polybutadiene (PBH) showing the lowest bond strengths, bis-GMA the highest, and bis-EMA/bis-GMA intermediary values. Single Bond yielded bond strengths of approximately 24 MPa. Water storage decreased the bond strength in all adhesives. Adhesive fractures were predominant in experimental adhesives, while mixed fractures were the most frequent type in the Single Bond group. Conclusion: The experimental dentin adhesives of this study were able to form resin tags, but they could not penetrate into the collagen fibers and form hybrid layers. The resulting low bond strength decreased with increasing length of storage.

Angiotensin-(1-7) decreases LPS-induced inflammatory response in macrophages

It has been previously shown that besides its classical role in blood pressure control the reninangiotensin system, mainly by action of angiotensin II on the AT1 receptor, exerts pro-inflammatory effects such as by inducing the production of cytokines. More recently, alternative pathways to this system were described, such as binding of angiotensin-(17) to receptor Mas, which was shown to counteract some of the effects evoked by activation of the angiotensin IIAT1 receptor axis. Here, by means of different molecular approaches we investigated the role of angiotensin-(17) in modulating inflammatory responses triggered in mouse peritoneal macrophages. Our results show that receptor Mas transcripts were up-regulated by eightfold in LPS-induced macrophages. Interestingly, macrophage stimulation with angiotensin-(17), following to LPS exposure, evoked an attenuation in expression of TNF-a and IL-6 pro-inflammatory cytokines; where this event was abolished when the receptor Mas selective antagonist A779 was also included. We then used heterologous expression of the receptor Mas in HEK293T cells to search for the molecular mechanisms underlying the angiotensin-(17)-mediated anti-inflammatory responses by a kinase array; what suggested the involvement of the Src kinase family. In LPS-induced macrophages, this finding was corroborated using the PP2 compound, a specific Src kinase inhibitor; and also by Western blotting when we observed that Ang-(17) attenuated the phosphorylation levels of Lyn, a member of the Src kinase family. Our findings bring evidence for an anti-inflammatory role for angiotensin-(17) at the cellular level, as well as show that its probable mechanism of action includes the modulation of Src kinases activities. J. Cell. Physiol. 227: 21172122, 2012. (C) 2011 Wiley Periodicals, Inc.

Dose-dependent effects of angiotensin-(1-7) on the NHE3 exchanger and [Ca(2+)](i) in in vivo proximal tubules

The acute direct action of angiotensin-(1-7) [ANG-(1-7)] on bicarbonate reabsorption (JHCO(3)(-)) was evaluated by stationary microperfusions on in vivo middle proximal tubules in rats using H ion-sensitive microelectrodes. The control JHCO(3)(-) is 2.82 ± 0.078 nmol·cm(-2)·s(-1) (50). ANG-(1-7) (10(-12) or 10(-9) M) in luminally perfused tubules decreases JHCO(3)(-) (36 or 60%, respectively), but ANG-(1-7) (10(-6) M) increases it (80%). A779 increases JHCO(3)(-) (30%) and prevents both the inhibitory and the stimulatory effects of ANG-(1-7) on it. S3226 decreases JHCO(3)(-) (45%) and changes the stimulatory effect of ANG-(1-7) to an inhibitory effect (30%) but does not affect the inhibitory effect of ANG-(1-7). Our results indicate that in the basal condition endogenous ANG-(1-7) inhibits JHCO(3)(-) and that the biphasic dose-dependent effect of ANG-(1-7) on JHCO(3)(-) is mediated by the Mas receptors via the Na(+)/H(+) exchanger 3 (NHE3). The control value of intracellular Ca(2+) concentration ([Ca(2+)](i)), as monitored using fura-2 AM, is 101 ± 2 nM (6), and ANG-(1-7) (10(-12), 10(-9), or 10(-6)M) transiently (3 min) increases it (by 151, 102, or 52%, respectively). A779 increases the [Ca(2+)](i) (25%) but impairs the stimulatory effect of all doses of ANG-(1-7) on it. The use of BAPTA or thapsigargin suggests a correlation between the ANG-(1-7) dose-dependent effects on [Ca(2+)](i) and JHCO(3)(-). Therefore, the interaction of the opposing dose-dependent effects of ANG II and ANG-(1-7) on [Ca(2+)](i) and JHCO(3)(-) may represent an physiological regulatory mechanism of extracellular volume and/or pH changes. However, whether [Ca(2+)](i) modification is an important direct mechanism for NHE3 activation by these peptides or is a side effect of other signaling pathways will require additional studies.