662 resultados para Rearrangements
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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CONTEXTO:Translocações robertsonianas (TR) estão entre os rearranjos estruturais balanceados mais comuns em humanos e compreendem a fusão da cromatina completa do braço longo de dois cromossomos acrocêntricos. No entanto, são raras as translocações não Robertsonianas envolvendo esses cromossomos.RELATO DE CASO:Nós descrevemos uma translocação não balanceada de novo envolvendo os cromossomos 15 e 21. A recém-nascida era filha de uma mãe de 29 anos e de um pai de 42 anos, casal não consanguíneo. Os achados clínicos levaram ao diagnóstico de síndrome de Down (SD) com defeitos cardíacos congênitos graves (persistência do canal arterial e defeito do septo atrioventricular completo), além de baixos comprimento e peso ao nascimento (< 5o e < 10o percentil em curvas de medidas específicas para SD, respectivamente). A análise citogenética convencional revelou o cariótipo 46,XX,der(15)(15pter→15q26.2
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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In this paper, we analyze the theoretical work of Renaud Barbaras, departing from his proposal to highlight and develop the potential of Husserl's theory of perception, based on the doctrine of perceptive donation according to profiles. We mainly focused on his work entitled Desire and distance: introduction to a phenomenology of perception. We underline the description, operated by the author, about the vital movement as desire and the characterization of the subject of the perception as living. In this condition, the formulation about the priority of a dimension emerges, qualified by Barbaras as pulsion towards the objectifying dimension of classical epistemology in the subject-object relation. We indicate that, according to the author, these rearrangements entail the need to consider the body, perception and movement based on the category of life.
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Canine transmissible venereal tumor (CTVT) is the oldest known somatic cell lineage. It is a transmissible cancer that propagates naturally in dogs. We sequenced the genomes of two CTVT tumors and found that CTVT has acquired 1.9 million somatic substitution mutations and bears evidence of exposure to ultraviolet light. CTVT is remarkably stable and lacks subclonal heterogeneity despite thousands of rearrangements, copy-number changes, and retrotransposon insertions. More than 10,000 genes carry nonsynonymous variants, and 646 genes have been lost. CTVT first arose in a dog with low genomic heterozygosity that may have lived about 11,000 years ago. The cancer spawned by this individual dispersed across continents about 500 years ago. Our results provide a genetic identikit of an ancient dog and demonstrate the robustness of mammalian somatic cells to survive for millennia despite a massive mutation burden.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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The present work is to analyze the importance of exchanging knowledge and technological innovation in Business Condominium Square Capital installed in the Metropolitan Region of Campinas (SP). The condominium corporate Capital Square is the new result of the productive rearrangements that allow the reproduction of capital. This new production space, endowed with infrastructure and sophisticated logistics is able to enable the development of companies installed there in addition to promoting the advancement of technological innovation in the region because of its relations with laboratories, universities and research centers. The research aims to contribute to the understanding of this new form of organization of space activities corresponding to the logic of exchange of knowledge and technological innovation. The logical location of innovation services have similar aspects to economic activities in general, which is distinguished due to the intangible nature of services of high added value through the strategic role of information, the nature of services and because there are services whose logic operation is beyond the economic, but also scientific. The project includes the study in an integrated environment, which allows to evaluate, under various aspects, the importance of established companies and infrastructure available that enable the advancement of skills and knowledge exchange in Capital Square Condo
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The oil market is not a common market, and its complexity increases dramatically when considering the strategic and geopolitical involved, thus resulting in large uncertainties and concerns. The attempt to control prices has always been a challenge for the major world powers, since the increase in oil prices benefits the exporting countries, but harms importers, especially those regarded as less developed. Understand and try to predict some strategies adopted up the oil crises is one of the main points of the research, in order to demonstrate how economics can be used as an instrument of power and domination between nations, and how plans and strategies and rearrangements of supply and demand favor the growth of this economy, especially in the current period, with the new Brazilian oil era, beginning with the discovery of pre-salt, amid a context of growing need for the use of oil and its derivatives
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The genus Corydoras, the highest among the Siluriformes, Callichthyidae is owned by the family, consisting of 177 valid species and widely distributed in cis-Andean portion of South America How striking feature has two longitudinal series of dermal plates covering almost the entire body. Cytogenetic studies in Callichthyidae show many chromosomal rearrangements, including events of polyploidy in their evolutionary history, particularly the genus Corydoras, in which the variation is the diploid number of 2n = 40 to 2n = 134 chromosomes. The absence of information on the frequency of chromosomes in the group Bs motivated this work with the species Corydoras aeneus. A population from the Tietê River basin in Ribeirão Claro (subbasin Corumbataí - Rio Claro, SP) was sampled a total of 20 subjects (10 males and 10 females) and 30 metaphases per individual were analyzed cytogenetically. Were carried out by impregnation techniques silver (Ag-NOR). The observed modal diploid number was 2n = 60 (26m +26 sm +8 st), with the variable occurrence of 1 or 2 Bs chromosomes in males and a B chromosome in females, both acrocentric. Regarding the variation in the frequency of chromosome Bs, the occurrence of two B chromosomes is directly linked to males, because there were no female sampled with the occurrence of two chromosomes Bs The low frequency of Bs in females suggests that this event can be sporadic this sex, different from males in which this appears to be set supernumerary chromosome showing a higher frequency of 2 Bs than the actual modal number of 2n = 60. Further studies will be performed to understand the dynamics of the B chromosome in the population