904 resultados para Port systemic shunt
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Port Weller Dry Docks Limited was officially established on April 25, 1946, near Lock 1 of the Welland Canal. Charles A. Ansell was the company’s first President and General Manager. Initially, the company focused on repairing ships, but in June, 1951, built their first ship, the Scott Misener. In 1956, the Upper Lakes and St. Lawrence Transportation Co. purchased all of the shares of Port Weller Dry Docks Limited. In the mid-eighties, ULS (Upper Lakes Shipping) International (which owned the Port Weller dry docks), and Canada Steamship Lines, merged their operations. As a result, the Port Weller Dry Docks became a division of this newly formed company, known as Canadian Shipbuilding and Engineering Limited. In 2007, Seaway Marine & Industrial Inc. took over ownership of the Port Weller Dry Docks, but declared bankruptcy in July 2013.
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Board of six postcards of Port Colborne. First postcard, Port Colborne Harbor, Port Colborne, Ont. Second postcard, Bird's-eye view showing entrance to Welland Canal, Port Colborne, Ont. Third postcard, Harbor, Port Colborne, Ont. Fourth postcard, Harbor Port, Port Colborne, Ont. Fifth postcard, Government elevator, capacity 2,000,000 bushels, Port Colborne, Ontario. Sixth postcard, caption unknown.
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During infection, the model plant Arabidopsis thaliana is capable of activating long lasting defence responses both in tissue directly affected by the pathogen and in more distal tissue. Systemic acquired resistance (SAR) is a type of systemic defence response deployed against biotrophic pathogens resulting in altered plant gene expression and production of antimicrobial compounds. One such gene involved in plant defence is called pathogenesis-related 1 (PR1) and is under the control of several protein regulators. TGA II-clade transcription factors (namely TGA2) repress PR1 activity prior to infection by forming large oligomeric complexes effectively blocking gene transcription. After pathogen detection, these complexes are dispersed by a mechanism unknown until now and free TGA molecules interact with the non-expressor of pathogenesis-related gene 1 (NPR1) protein forming an activating complex enabling PR1 transcription. This study elucidates the TGA2 dissociation mechanism by introducing protein kinase CK2 into this process. This enzyme efficiently phosphorylates TGA2 resulting in two crucial events. Firstly, the DNA-binding ability of this transcription factor is completely abolished explaining how the large TGA2 complexes are quickly evicted from the PR1 promoter. Secondly, a portion of TGA2 molecules dissociate from the complexes after phosphorylation which likely makes them available for the formation of the TGA2-NPR1 activating complex. We also show that phosphorylation of a multiserine motif found within TGA2’s N terminus is responsible for the change of affinity to DNA, while modification of a single threonine in the leucine zipper domain seems to be responsible for deoligomerization. Despite the substantial changes caused by phosphorylation, TGA2 is still capable of interacting with NPR1 and these proteins together form a complex on DNA promoting PR1 transcription. Therefore, we propose a change in the current model of how PR1 is regulated by adding CK2 which targets TGA2 displacing it’s complexes from the promoter and providing solitary TGA2 molecules for assembly of the activating complex. Amino acid sequences of regions targeted by CK2 in Arabidopsis TGA2 are similar to those found in TGA2 homologs in rice and tobacco. Therefore, the molecular mechanism that we have identified may be conserved among various plants, including important crop species, adding to the significance of our findings.
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Bill to Dilly Coleman from Mr. Dilke of Port Robinson, April 11, 1850.
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Letter from Port Robinson to Mr. Bell acknowledging the receipt for the affidavits which were sent. The writer says that he is not the owner of the land as Mr. Bell supposes. The writer is anxious for this matter to be brought before the committee and says that this matter has been 2 years in Mr. Steer’s hands in neglect. [The letter is unsigned, but the writer is probably Samuel D. Woodruff], April 10, 1849.
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Letter to George Rykert (president of the Port Dalhousie and Thorold Railway), engineer from William Danforth, civil engineer in which he states that the preliminary survey has been made between Port Dalhousie and Centreville at which point it may intersect with the Great Western Railway. The estimate is included (2 pages, handwritten), July 25, 1853.
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Notice that the Port Dalhousie and Thorold Railway map and plans have been certified by commissioners. This is signed “secretary”, n.d.
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Letter which contains a report to George Rykert of Friends of the Port Dalhousie Thorold Railway. In this unsigned letter regarding contracts for the railway, it is suggested that the quantity of the excavation could have been done at 25 cents less per yard, July 23, 1855.
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Letter to Mr. Ingersoll, secretary of the Port Dalhousie and Thorold Railway from S.D. Woodruff regarding a letter from F. Lalor on the 25th of October which is about claims of expenses, Dec. 4, 1856.
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Original estimate of Mr. Danforth on the Port Dalhousie and Thorold Railway (1 page, handwritten), Nov. 3, 1853.
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Specifications and form of tender for grading for the Port Dalhousie and Thorold Railway, March (5 pages, handwritten), 1854.
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Approximate cost of completing the railway from Port Dalhousie to St. Catharines and an estimate of the cost of the piers at Port Dalhousie signed by William Hamilton Merritt (5 pages, handwritten), July 8, 1854.
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Approximate estimate of the cost of completing the Port Dalhousie Railway to the Grand Central Railway Station at Lock 12. This document is badly torn and burned but most of the text is legible, July 14, 1854.
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Estimated cost of the Port Dalhousie and Thorold Railway sent to George Rykert by S.D. Woodruff, Aug. 5, 1854.
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Letter sent from the Port Dalhousie and Thorold Railway to the Town Council of St. Catharines which states that the estimate that was submitted does not embrace the damages done to the buildings along Line no. 1 from Port Dalhousie to Chisholm Corner. The estimates are included in the document, Aug. 17, 1854.