The Augusta survey : a community study and population census of the city of Augusta, Maine /

"Errata" slip mounted on p. 63.

Sword of liberty ; the story of two revolutions

Mode of access: Internet.

1970 census of population. Characteristics of the population : South Dakota.

On cover: 1970 census of population.

1970 census of population. Characteristics of the population.

Mode of access: Internet.

1970 census of population. Characteristics of the population : United States summary.

On cover: 1970 census of population.

1970 census of population : characteristics of the population : New Mexico.

Constitutes v. 1, pt. 33 of the 1970 census of population.

Children deprived of adoption; a report August, 1955.

Mode of access: Internet.

An address to the inhabitants of Great Britain on the dangerous and destructive tendency of the French system of liberty and equality, with an historical account of the French revolution, the imprisonment and sufferings of the royal family, and the deliberate murder of the unfortunate king of France ...

Mode of access: Internet.

Assessors' land valuations, city of Chicago, from the quadrennial assessment of 1907 with systems of valuing real estate, tables showing increase of population and of values,

Includes advertisements.

Print, Publicity and Radicalism in the 1790s : The Laurel of Liberty /

Jon Mee explores the popular democratic movement that emerged in the London of the 1790s in response to the French Revolution. Central to the movement’s achievement was the creation of an idea of ‘the people’ brought into being through print and publicity. Radical clubs rose and fell in the face of the hostile attentions of government. They were sustained by a faith in the press as a form of ‘print magic,’ but confidence in the liberating potential of the printing press was interwoven with hard-headed deliberations over how best to animate and represent the people. Ideas of disinterested rational debate were thrown into the mix with coruscating satire, rousing songs, and republican toasts. Print personality became a vital interface between readers and print exploited by the cast of radicals returned to history in vivid detail by Print, Publicity, and Popular Radicalism.

Population pharmacokinetics of hydroxychloroquine in patients with rheumatoid arthritis

Hydroxychloroquine (HCQ) is an antimalarial drug that is also used as a second-line treatment of rheumatoid arthritis (RA). Clinically, the use of HCQ is characterized by a long delay in the onset of action, and withdrawal of treatment is often a result of inefficacy rather than from toxicity. The slow onset of action can be attributed to the pharmacokinetics (PK) of HCQ, and wide interpatient variability is evident. Tentative relationships between concentration and effect have been made, but to date, no population PK model has been developed for HCQ. This study aimed to develop a population PK model including an estimation of the oral bioavailability of HCQ. In addition, the effects of the coadministration of methotrexate on the PK of HCQ were examined. Hydroxychloroquine blood concentration data were combined from previous pharmacokinetic studies in patients with rheumatoid arthritis. A total of 123 patients were studied, giving the data cohort from four previously published studies. Two groups of patients were included: 74 received hydroxychloroquine (HCQ) alone, and 49 received HCQ and methotrexate (MTX). All data analyses were carried out using the NONMEM program. A one-compartment PK model was supported, rather than a three-compartment model as previously published, probably because of the clustering of concentrations taken at the end of a dosing interval. The population estimate of bioavailability of 0.75 (0.07), n = 9, was consistent with literature values. The parameter values from the final model were: (Cl) over bar = 9.9 +/- 0.4 L/h, (V) over bar 605 +/- 91 L, (k(d)) over bar = 0.77 +/- 0.22 hours(-1), (t(tag)) over bar = 0.44 +/- 0.02 hours. Clearance was not affected by the presence of MTX, and, hence, steady-state drug concentrations and maintenance dosage requirements were similar. A population PK model was successfully developed for HCQ.