A computational model coupling mechanics and electrophysiology in spinal cord injury

Traumatic brain injury and spinal cord injury have recently been put under the spotlight as major causes of death and disability in the developed world. Despite the important ongoing experimental and modeling campaigns aimed at understanding the mechanics of tissue and cell damage typically observed in such events, the differenti- ated roles of strain, stress and their corresponding loading rates on the damage level itself remain unclear. More specif- ically, the direct relations between brain and spinal cord tis- sue or cell damage, and electrophysiological functions are still to be unraveled. Whereas mechanical modeling efforts are focusing mainly on stress distribution and mechanistic- based damage criteria, simulated function-based damage cri- teria are still missing. Here, we propose a new multiscale model of myelinated axon associating electrophysiological impairment to structural damage as a function of strain and strain rate. This multiscale approach provides a new framework for damage evaluation directly relating neuron mechanics and electrophysiological properties, thus provid- ing a link between mechanical trauma and subsequent func- tional deficits.

Expression of xyloglucan endotransglucosylase/hydrolase (XTH) genes and XET activity in ethylene treated apple and tomato fruits.

Xyloglucan endotransglucosylase/hydrolase (XTHs: EC 2.4.1.207 and/or EC 3.2.1.151), a xyloglucan modifying enzyme, has been proposed to have a role during tomato and apple fruit ripening by loosening the cell wall. Since the ripening of climacteric fruits is controlled by endogenous ethylene biosynthesis, we wanted to study whether XET activity was ethylene-regulated, and if so, which specific genes encoding ripening-regulated XTH genes were indeed ethylene-regulated. XET specific activity in tomato and apple fruits was significantly increased by the ethylene treatment, as compared with the control fruits, suggesting an increase in the XTH gene expression induced by ethylene. The 25 SlXTH protein sequences of tomato and the 11 sequences MdXTH of apple were phylogenetically analyzed and grouped into three major clades. The SlXTHs genes with highest expression during ripening were SlXTH5 and SlXTH8 from Group III-B, and in apple MdXTH2, from Group II, and MdXTH10, and MdXTH11 from Group III-B. Ethylene was involved in the regulation of the expression of different SlXTH and MdXTH genes during ripening. In tomato fruit fifteen different SlXTH genes showed an increase in expression after ethylene treatment, and the SlXTHs that were ripening associated were also ethylene dependent, and belong to Group III-B (SlXTH5 and SlXTH8). In apple fruit, three MdXTH showed an increase in expression after the ethylene treatment and the only MdXTH that was ripening associated and ethylene dependent was MdXTH10 from Group III-B. The results indicate that XTH may play an important role in fruit ripening and a possible relationship between XTHs from Group III-B and fruit ripening, and ethylene regulation is suggested.

Coleccion de las obras sueltas, assi en prosa, como en verso

Contiene : La Circe, p. 1-106 ; La Mañana de San Juan, p. 107-136 ; La Rosa Blanca, p. 137-164 ; La Dragontea, p. 165-373 ; Fiestas de Denia, p. 376-428 ; Soneto de Carlos Boil a Lope de Vega, p. 429 ; Poesias Varias, p. 431-508

Relacion del seru[icio] que Adrian Bay[arte] ... ha hecho a su Mag[estad] en la Comiss[i]on que lleuo al Reyno de Val[enci]a y de lo que queda por hacer [Manuscrito]

Alcance y contenido: Copia ms. con la relación sumaria de la Comisión/nes encargadas a D. Adrián Bayarte, caballero aragonés, nombrado Comisario General en Valencia por el rey Felipe III, para que en dicho reino tasase y vendiese "las haziendas que los moriscos dexaron en las ciudades y villas reales", pagando todas las deudas y censales justificados sobre dichos bienes. El número de comisiones encargadas por el rey a Adrián Bayarte ascendieron a 4, realizadas entre 1614 y 1617. Al final del texto aparece "Vto. Dr. Ambrosio Alos"

Cartas de Don Nicolas Antonio y de Don Antonio de Solis : añadese una de Don Christoval Crespi de Valdaura

Sign.: a12, e4, A8, B4, C8, D4, E8, F4, G8, H4, I8, K4, L8, M4

Potassium (K+) in plants.

Potassium (K+) is the most abundant inorganic cation in plant cells. This is an editorial for a compendium prepared by 34 authors that provides a stock-check of the current knowledge in the field and provides a first step toward a holistic view on ?Potassium (K+) in Plants?.

Relationi vniversali

Dedicatoria fechada en diciembre de 1598

La seconda parte delle Relationi vniuersali

Hay un ejemplar encuadernado con: Relationi universali (XVI/512).

La terza parte delle Relationi vniversali

Hay un ejemplar encuadernado con: Relationi universali (XVI/512).

La quarta parte delle Relationi uniuersali

Hay un ejemplar encuadernado con: Relationi universali (XVI/512).

Bibliotheca hispana nova [Texto impreso] : sive hispanorum scriptorum qui ab anno MD. ad MDCLXXXIV floruere notitia

Mención de ed. precede a número de parte

Descripcion de todas las provincias, reynos, estados, y ciudades principales del mundo [Texto impreso] : sacada de las relaciones toscanas de Juan Botero Benes en que se trata de las costumbres, industria ... de Europa, Asia, Africa ...

Existe una ed. con el mismo pie de imp., pero con diferente signaturización tipográfica

A computational model coupling mechanics and electrophysiology in spinal cord injury

Traumatic brain injury and spinal cord injury have recently been put under the spotlight as major causes of death and disability in the developed world. Despite the important ongoing experimental and modeling campaigns aimed at understanding the mechanics of tissue and cell damage typically observed in such events, the differentiated roles of strain, stress and their corresponding loading rates on the damage level itself remain unclear. More specifically, the direct relations between brain and spinal cord tissue or cell damage, and electrophysiological functions are still to be unraveled. Whereas mechanical modeling efforts are focusing mainly on stress distribution and mechanistic-based damage criteria, simulated function-based damage criteria are still missing. Here, we propose a new multiscale model of myelinated axon associating electrophysiological impairment to structural damage as a function of strain and strain rate. This multiscale approach provides a new framework for damage evaluation directly relating neuron mechanics and electrophysiological properties, thus providing a link between mechanical trauma and subsequent functional deficits

Periquillo el de las gallineras [Texto impreso]

Marca tip. en port

Concio de arcano Christi nascentis mysterio [Texto impreso]

Sign.: A10