Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health

Bone metabolism involves a complex balance between the deposition of matrix and mineralization and resorption. There is now good evidence that dietary components and herbal products can influence these processes, particularly by inhibiting bone resorption, thus having beneficial effects on the skeleton. For example, it has been reported that a number of common vegetables, including onion, garlic and parsley, can inhibit bone resorption in ovariectomized rats. Essential oils derived from sage, rosemary, thyme and other herbs inhibit osteoclast activity in vitro and in vitro and leading to an increase in bone mineral density. Soya, a rich source of isoflavones, has shown promising results and epidemiological evidence to support a use in maintaining bone health, and various traditional herbal formulae in Chinese and Ayurvedic medicine also have demonstrable effects in pharmacological models of osteoporosis. Recently, cannabinoids have been described as having positive effects on osteoblast differentiation, and the presence of cannabinoid receptors in bone tissue indicates a more complex role in bone metabolism than previously thought. The first part of this review briefly discusses normal bone metabolism and disorders caused by its disruption, with particular reference to osteoporosis and current pharmacological treatments. The effects of natural products on bone and connective tissue are then discussed, to include items of diet, herbal extracts and food supplements, with evidence for their efficacy outlined. Copyright (c) 2006 John Wiley & Sons, Ltd.

Milk and meat in our diet: good or bad for health?

Foods derived from animals are an important source of nutrients in the diet but there is considerable uncertainty about whether or not these foods contribute to increased risk of various chronic diseases. For milk in particular there appears to be an enormous mismatch between both the advice given on milk/dairy foods items by various authorities and public perceptions of harm from the consumption of milk and dairy products, and the evidence from long-term prospective cohort studies. Such studies provide convincing evidence that increased consumption of milk can lead to reductions in the risk of vascular disease and possibly some cancers and of an overall survival advantage from the consumption of milk, although the relative effect of milk products is unclear. Accordingly, simply reducing milk consumption in order to reduce saturated fatty acid (SFA) intake is not likely to produce benefits overall though the production of dairy products with reduced SFA contents is likely to be helpful. For red meat there is no evidence of increased risk of vascular diseases though processed meat appears to increase the risk substantially. There is still conflicting and inconsistent evidence on the relationship between consumption of red meat and the development of colorectal cancer, but this topic should not be ignored. Likewise, the role of poultry meat and its products as sources of dietary fat and fatty acids is not fully clear. There is concern about the likely increase in the prevalence of dementia but there are few data on the possible benefits or risks from milk and meat consumption. The future role of animal nutrition in creating foods closer to the optimum composition for long-term human health will be increasingly important. Overall, the case for increased milk consumption seems convincing, although the case for high-fat dairy products and red meat is not. Processed meat products do seem to have negative effects on long-term health and although more research is required, these effects do need to be put into the context of other risk factors to long-term health such as obesity, smoking and alcohol consumption.

Effects of increased wholegrain consumption on immune and inflammatory markers in healthy low habitual wholegrain consumers

Purpose Wholegrain (WG) consumption is associated with reduced risk of cardiovascular disease, but clinical data on inflammation and immune function is either conflicting or limited. The objective of this study was to assess the impact of increasing WG consumption to at least 80 g/d on markers of inflammation and glucose metabolism and on phenotypic and functional aspects of the immune system, in healthy, middle-aged adults with low habitual WG intake. Methods Subjects consumed a diet high in WG (> 80 g/d) or low in WG (< 16 g/d, refined grain diet) in a crossover study, with 6-week intervention periods, separated by a 4-week washout. Adherence to the dietary regimes was achieved by dietary advice and provision of a range of food products, with compliance verified through analysis of plasma alkylresorcinols (ARs). Results On the WG intervention, WG consumption reached 168 g/d (P < 0.001), accompanied by an increase in plasma ARs (P < 0.001) and fibre intake (P < 0.001), without affecting other aspects of dietary intake. On the WG arm there were trends for lower ex vivo activation of CD4+ T cells and circulating concentrations of IL-10, C-reactive protein, C-peptide, insulin and plasminogen activator inhibitor-1. The percentage of CD4+ central memory T cells and circulating levels of adipsin tended to increase during the WG intervention. Conclusions Despite the dramatic increase in WG consumption, there were no effects on phenotypic or functional immune parameters, markers of inflammation or metabolic markers.

Garlic (Allium sativum L.) and ready-to-eat garlic products: In vitro antioxidant activity

Garlic contains polyphenol and sulphur compounds, which are responsible for its antioxidant activity (AA). This study aimed at evaluating the AA of fresh garlic and its commercialised products and their shelf life. Fresh garlic (FG) and its products, i.e. chopped with salt (CGS), chopped without Salt (CG), fried (FRG) and mixed garlic (FG with dehydrated garlic; MG) antioxidant activity was evaluated by three different methods: DPPH (1,1-diphenyl-2-picrylhydrazyl) assay, beta-carotene/linoleic acid assay and Rancimat method. Amongst all the analysed products, fried garlic presented the highest antioxidant activity. The free radical-scavenging activity decreased during the shelf life of all analysed products that correlated with the decrease in the total polyphenol content. Our findings suggest that some compounds other than phenol may have contributed towards this outcome. (c) 2008 Elsevier Ltd. All rights reserved.

Characterization of the products of aniline peroxydisulfate oligo/polymerization in media with different pH by resonance Raman spectroscopy at 413.1 and 1064 nm excitation wavelengths

The pH-structure correlation of the products of aniline peroxydisulfate reaction was mainly investigated by resonance Raman spectroscopy. The reactions of aniline and ammonium peroxydisulfate were carried out in aqueous solutions of initial pH ranging from 4.9 to 13.2 and monomer/oxidant molar ratio of 4/1. For an initial pH of 4.9, the spectroscopic techniques showed that the emeraldine salt form of polyaniline (PANI-ES) is the main product, corroborating that the usual head-to-tail coupling mechanism is taking place. The resonance Raman spectra at 1064 nm exciting wavelength were useful to detect the emeraldine salt as a minor product for reactions at an initial pH of 5.3-11.5. The Raman spectra of the main product of the reaction at initial pH of 13.2 excited at 1064 and 413.1 nm showed new spectral features consistent with 1,4-Michael-type adducts of aniline monomers and 1,4-benzoquinone-monoimine unit. These compounds and their products of hydrolysis/oxidation are the predominant species for the reaction media of initial pH from 5.3 to 13.2. In order to get PANI with different nanoscale morphologies, a pH value of more than 0 or 1 was used in the aniline polymerization. The spectroscopic data obtained in this work reveal that head-to-tail coupling does not occur when aniline reacts at media pH higher than about 5. It is suggested that chemical structures of the products of aniline oxidation by an unusual mechanism are the driving force for the development of assorted morphologies. Copyright (C) 2011 John Wiley & Sons, Ltd.

Práticas e resultados de apreçamento nas empresas brasileiras - 1ª Parte

Este relatório refere-se à primeira parte de uma pesquisa financiada pelo Núcleo de Pesquisas e Publicações (GV-PESQUISA) da EAESP-FGV e apoiada pelo Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Trata-se dos determinantes do desempenho de novos produtos, um tema ainda pouco estudado no Brasil, a partir de um modelo integrativo das concepções de INGENBLEEK, DREBUYNE, FRAMBACH & VERHALLEN (2004) e HENARD & SZYMANSKI (2001). Formou-se uma amostra de 109 gerentes de produto e diretores de marketing de empresas estrangeiras atuando no Brasil. O Desempenho do Novo Produto apresentou uma relação significativa e positiva com Orientação para o Mercado e Processo de Desenvolvimento de Novos Produtos. O Desempenho de Mercado do Novo Produto mostrou uma relação significativa e positiva com Características dos Processos da Empresa, Vantagem Relativa do Novo Produto e Características do Mercado. O Desempenho Financeiro do Novo Produto apareceu com uma relação significativa com Características dos Processos da Empresa (positiva), Características Estratégicas da Empresa (positiva) e Incerteza da Demanda (negativa). Ao final, são apontadas e discutidas, de modo preliminar, as limitações, conclusões e implicações da pesquisa.

Instrumentos de apoio financeiro específicos a empresas localizadas em arranjos produtivos locais: um estudo de caso do APL de Nova Friburgo

In the last decade, the debate concerning more adequate means of promoting social and economic development, through policies of firm supporting, has been gaining strength. Among several means of support, there is one that addresses issues related to credit and funding. At the same time, interest on the phenomenon of firm agglomeration, known by clustering, is increasing, as well as one of its advantages - facilitating the development and strengthening of its firms. Additionally, there can be spotted advantages on clustering that allow tailoring financial instruments, specifically to firms in it, based on collective solutions, with better conditions. This dissertation focuses on how the capture of these opportunities is being done, in the presence of specific financial products to Brazilian clusters. The present analysis is conducted from the cluster located in Nova Friburgo and Region, specialized in women underwear. This study sought to capture advantages from three main collective solutions: information systems, guarantees systems, alternative funding. These solutions address to the following issues: information asymmetries, absence of guarantees from the credit taker, limited sources of funding. Semi-structured interviews were made with members of the cluster, when it was possible to identify that the capture of advantages is in its early stages, being limited by other issues, such as: adequate degree of human capital, governance framework and process inefficiencies.

Impacto da servitização no modelo de negócio de empresas manufatureiras : o caso Scania

Muitas empresas manufatureiras buscam aumentar a participação dos serviços em seus negócios. Essa estratégia é conhecida como servitização e significa aumentar a oferta de pacotes combinados de produtos e serviços com foco nos clientes e seus negócios. Porém, a servitização constitui um grande desafio para essas empresas, pois seus modelos de negócio tradicionais tem foco no desenvolvimento, produção e venda de produtos. Esta pesquisa investiga como uma empresa manufatureira modifica seu modelo de negócio para aumentar sua servitização. A pesquisa também analisa quais são as motivações para que uma empresa busque isso e quais são os desafios que ela enfrenta nessa busca. Com esses objetivos, realizou-se um estudo de caso de uma montadora de veículos pesados com operações globais e presença consolidada no Brasil. Conduziu-se entrevistas com 8 executivos da empresa, responsáveis por Vendas, Serviços, Marketing e Produção no Brasil e América Latina. As entrevistas foram combinadas com análise de documentos da empresa entre os anos de 1996 e 2011. Utilizou-se o conceito de modelo de negócio como unidade básica de análise, já que este conceito explica como uma empresa cria, entrega e captura valor. Os resultados mostram que o modelo de negócio da empresa está em transição, de seu foco tradicional em produto, para maior centralidade do cliente e suas operações. A proposta de valor da empresa passou a enfatizar o desempenho de seus pacotes de produtos e serviços nas operações dos clientes, ao invés do foco tradicional na qualidade dos produtos. A empresa também criou novas organizações, processos e métricas com foco nos clientes e novos modelos de receitas, baseados em contratos de risco e na venda de desempenho e disponibilidade. Os resultados mostram que a empresa possui motivações estratégicas, financeiras e de marketing para buscar a servitização. Eles também mostram que o alinhamento das diversas áreas da empresa e de sua rede de parceiros, para maior foco nos clientes e em serviços, ao invés do seu foco tradicional no produto, ainda representa um importante desafio empresarial.

Precificação em orquestradores de informação: maximizando redes estáveis

Em redes de inovação baseadas em trocas de informação, o agente orquestrador se apropria das informações dos atores periféricos, gera inovação e distribui em forma de valor agregado. É sua função promover a estabilidade na rede fazendo com que a mesma tenha taxas não negativas de crescimento. Nos mercados de análise de crédito e fraude, por exemplo, ou bureaus funcionam como agentes orquestradores, concentrando as informações históricas da população que são provenientes de seus clientes e fornecendo produtos que auxiliam na tomada de decisão. Assumindo todas as empresas do ecossistema como agentes racionais, a teoria dos jogos se torna uma ferramenta apropriada para o estudo da precificação dos produtos como mecanismo de promoção da estabilidade da rede. Este trabalho busca identificar a relação de diferentes estruturas de precificação promovidas pelo agente orquestrador com a estabilidade e eficiência da rede de inovação. Uma vez que o poder da rede se dá pela força conjunta de seus membros, a inovação por esta gerada varia de acordo com a decisão isolada de cada agente periférico de contratar o agente orquestrador ao preço por ele estipulado. Através da definição de um jogo teórico simplificado onde diferentes agentes decidem conectar-se ou não à rede nas diferentes estruturas de preços estipuladas pelo agente orquestrador, o estudo analisa as condições de equilíbrio conclui que o equilíbrio de Nash implica em um cenário de estabilidade da rede. Uma conclusão é que, para maximizar o poder de inovação da rede, o preço a ser pago por cada agente para fazer uso da rede deve ser diretamente proporcional ao benefício financeiro auferido pela inovação gerada pela mesma. O estudo apresenta ainda uma simulação computacional de um mercado fictício para demonstração numérica dos efeitos observados. Através das conclusões obtidas, o trabalho cobre uma lacuna da literatura de redes de inovação com agentes orquestradores monopolistas em termos de precificação do uso da rede, servindo de subsídio de tomadores de decisão quando da oferta ou demanda dos serviços da rede.

Evaluating the links between intake of milk/dairy products and cancer

Milk and dairy products are widely recommended as part of a healthy diet. These products, however, can contain hormones such as insulin-like growth factor 1, and some studies have suggested that a high intake of milk and dairy products may increase the risk of cancer. This review examines recent studies on this topic, with the evidence suggesting that the recommended intake of milk and dairy products (3 servings/day) is safe and, importantly, does not seem to increase the risk of cancer. on the basis of the studies included in this review, cultured milk, yogurt, and low-fat dairy products should be preferred as the milk and dairy products of choice.

Antibacterial properties of propolis and products containing propolis from Brazil

Crude propolis and commercial products containing propolis, such as ethanolic extracts, tablets, capsules and powders acquired in São Paulo City (Brazil) were analyzed. The resins of the solid products were extracted with ethanol and found to be present at various concentrations, independently of the propolis concentration specified on the label of the commercial products. The in vitro activity of these resins against S aureus, B cereus and B subrilis was also determined. The results showed that the antibacterial activity rather than the propolis concentration itself should be considered for quality control and that some resins are likely to display a species-specific action.

Competencia bancaria en México

Incluye Bibliografía

A new approach to development banking in Jamaica

Includes bibliography

The macroeconomics of the Latin American economic boom

Includes bibliography

Global economic developments, 1999

Includes bibliography