Bedencken, ob christliche Oberkeiten, die im heiligen römischen Reich gesessene Jüdischheit bey derohabenden Thorach und Thalmud mit guten Gewissen ... in Unwissenheit könne und möge sitzen lassen?

Alles ... gestellt durch einen liebhaber der Warheit und Gerechtigkeit

Deutsches Reich, Judentum und Sozialismus : eine Rede an die Freideutsche Jugend

von Hans Blüher

Judentum und Christentum : Vortr. geh. in d. Montefiore-Loge U.O.B.B.

von Maximilian Stein

Im Kriegsjahr 1914/15 : Bittgebet für Kaiser, Volk und Vaterland

von Abraham Glaßberg

Das mosaisch-talmudische Eherecht : auf Verlangen Kaiser Josefs des Zweiten ... erstattetes Gutachten

von Ezekiel Landau. Zum ersten Male veröffentl. u. mit Einl. u. Anm. vers. von Alexander Kisch

Sefer Yesod emunat

von Ernst Maximilian Borg

An Eine Hoch-löbliche allgemeine Reichs-Versammlung unterthanig- gehorsamst- angelegenes Memoriale und Bitten von Städt. Burgermeistern und Rath des Heil. Röm. Reichs Freyer Stadt Worms : dasiger Judenschafft neuerlich suchende besondere Huldigung und die zu Abwendung derselben an Ihro Kayserl. Majestät vom Reich zu erlassen gebettene intercessionales betreffend ; samt Beyl.

In Fraktur

The influence of tibial morphology on the design of an anatomical tibial baseplate for TKA.

BACKGROUND Finding the right balance between tibial coverage and minimal implant overhang is an important factor in TKA. Another significant cause of failure is component malrotation. METHODS An average master shape of the proximal tibia at TKA resection level was calculated using fine slice computed tomographies of 117 cadaveric knees. To find out whether alternate implant contours would be necessary depending on the patient's body size, we established five subgroups to compare. CAD-Analysis was performed to simulate the overhang produced after ±4°/±7°/±10° rotation. RESULTS A master shape for the tibial resection cut (with a 5° posterior slope, 7 mm under lateral joint line) could be determined. Neither left vs. right knee joint, nor male vs. female nor the size subdivision appears to alter the calculated master shape significantly. The optimized shape allowing for ±4° of rotational freedom was found to be the best variant. CONCLUSIONS Valid methods have been obtained to design a two-dimensional average shape of the tibial plateau. The modifications described in this study might come in useful, when designing future implant designs. CLINICAL RELEVANCE An optimized fit at the tibial plateau and lower rates of component malrotation may result in better outcomes after TKA.

Impact of miR-21, miR-126 and miR-221 as prognostic factors of clear cell renal cell carcinoma with tumor thrombus of the inferior vena cava

Clear cell renal cell carcinoma (ccRCC) characterized by a tumor thrombus (TT) extending into the inferior vena cava (IVC) generally indicates poor prognosis. Nevertheless, the risk for tumor recurrence after nephrectomy and thrombectomy varies. An applicable and accurate prediction system to select ccRCC patients with TT of the IVC (ccRCC/TT) at high risk after nephrectomy is urgently needed, but has not been established up to now. To our knowledge, a possible role of microRNAs (miRs) for the development of ccRCC/TT or their impact as prognostic markers in ccRCC/TT has not been explored yet. Therefore, we analyzed the expression of the previously described onco-miRs miR-200c, miR-210, miR-126, miR-221, let-7b, miR-21, miR-143 and miR-141 in a study collective of 74 ccRCC patients. Using the expression profiles of these eight miRs we developed classification systems that accurately differentiate ccRCC from non-cancerous renal tissue and ccRCC/TT from tumors without TT. In the subgroup of 37 ccRCC/TT cases we found that miR-21, miR-126, and miR-221 predicted cancer related death (CRD) accurately and independently from other clinico-pathological features. Furthermore, a combined risk score based on the expression of miR-21, miR-126 and miR-221 was developed and showed high sensitivity and specificity to predict cancer specific survival (CSS) in ccRCC/TT. Using the combined risk score we were able to classify ccRCC/TT patients correctly into high and low risk cases. The risk stratification by the combined risk score (CRS) will benefit from further cohort validation and might have potential for clinical application as a molecular prediction system to identify high- risk ccRCC/TT patients.

Vater, Sohn und Enkel : 2 Denkschriften ... dem ... Kaiser Alexander Nikolajewitsch dem Befreier 1863, dem regierenden Kaiser Alexander Alexandrowitsch ... zu dessen Krönung am 15. Mai 1883 ... eingereicht, zur Feier d. Mündigkeitserklärung ... des Großfürsten Thronfolgers Nikolai Alexandrowitsch am 6. Mai

veröffentlicht vom Sim[e]on Leon [v.] Schwabacher

Combination of expression levels of miR-21 and miR-126 is associated with cancer-specific survival in clear-cell renal cell carcinoma

BACKGROUND Renal cell carcinoma (RCC) is marked by high mortality rate. To date, no robust risk stratification by clinical or molecular prognosticators of cancer-specific survival (CSS) has been established for early stages. Transcriptional profiling of small non-coding RNA gene products (miRNAs) seems promising for prognostic stratification. The expression of miR-21 and miR-126 was analysed in a large cohort of RCC patients; a combined risk score (CRS)-model was constructed based on expression levels of both miRNAs. METHODS Expression of miR-21 and miR-126 was evaluated by qRT-PCR in tumour and adjacent non-neoplastic tissue in n = 139 clear cell RCC patients. Relation of miR-21 and miR-126 expression with various clinical parameters was assessed. Parameters were analysed by uni- and multivariate COX regression. A factor derived from the z-score resulting from the COX model was determined for both miRs separately and a combined risk score (CRS) was calculated multiplying the relative expression of miR-21 and miR-126 by this factor. The best fitting COX model was selected by relative goodness-of-fit with the Akaike information criterion (AIC). RESULTS RCC with and without miR-21 up- and miR-126 downregulation differed significantly in synchronous metastatic status and CSS. Upregulation of miR-21 and downregulation of miR-126 were independently prognostic. A combined risk score (CRS) based on the expression of both miRs showed high sensitivity and specificity in predicting CSS and prediction was independent from any other clinico-pathological parameter. Association of CRS with CSS was successfully validated in a testing cohort containing patients with high and low risk for progressive disease. CONCLUSIONS A combined expression level of miR-21 and miR-126 accurately predicted CSS in two independent RCC cohorts and seems feasible for clinical application in assessing prognosis.