Peroxisome proliferator-activated receptors A link between endocrinology and nutrition?

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily like the steroid, thyroid, or retinoid hormone receptors, which are ligand-activated transcription factors regulating gene expression. PPARs mediate the induction of the enzymes of the peroxisomal and microsomal fatty-acid oxidation pathways by hypolipidemic drugs such as clofibrate and are probably also involved in the gene expression of other lipid-metabolism-associated proteins that are controlled by fibrate hypolipidemic drugs. That PPARs play an important role in the regulation of lipid metabolism is reinforced by the discovery of their activation by physiologic concentrations of fatty acids. This observation raises the question of whether fatty acids are ligands of PPARs, which would imply that nutritional fatty acids can act like hormones.

Motor Vehicle Accident Fatalities for the Week Ending, February 16, 2007

Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.

EPI Update, February 16, 2007

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.

ABD e-News, February 16, 2007

Weekly Newsletter

Iowa Developments, February 2007, Vol. 16, no. 2

Business news from the Iowa Department of Economic Development

Archives parlementaires de 1787 à 1860 ; 8-17, 19, 21-33. Assemblée nationale constituante. 19. Du 16 septembre 1790 au 23 octobre 1790 / impr. par ordre du Sénat et de la Chambre des députés ; sous la dir. de M. J. Mavidal,... et de M. E. Laurent,...

Collection : Les archives de la Révolution française ; 3.1

Archives parlementaires de 1787 à 1860 ; 8-17, 19, 21-33. Assemblée nationale constituante. 16. Du 31 mai 1790 au 8 juillet 1790 / impr. par ordre du Sénat et de la Chambre des députés ; sous la dir. de M. J. Mavidal,... et de M. E. Laurent,...

Collection : Les archives de la Révolution française ; 3.1

Archives parlementaires de 1787 à 1860 ; 8-17, 19, 21-33. Assemblée nationale constituante. 9. Du 16 septembre 1789 au 11 novembre 1789 / impr. par ordre du Sénat et de la Chambre des députés ; sous la dir. de M. J. Mavidal,... et de M. E. Laurent,...

Collection : Les archives de la Révolution française ; 3.1

Secure & Prepared, August 22, 2006, Vol.2, no.16

Secure & Prepared is a bi-weekly publication of the Iowa Homeland Security & Emergency Management Division for those involved in the homeland security system in the state of Iowa.