Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.

Recent studies have demonstrated the existence of a soluble fibroblast growth factor (FGF) receptor type 1 (FGFR1) extracellular domain in the circulation and in vascular basement membranes. However, the process of FGFR1 ectodomain release from the plasma membrane is not known. Here we report that the 72-kDa gelatinase A (matrix metalloproteinase type 2, MMP2) can hydrolyze the Val368-Met369 peptide bond of the FGFR1 ectodomain, eight amino acids upstream of the transmembrane domain, thus releasing the entire extracellular domain. Similar results were obtained regardless of whether FGF was first bound to the receptor or not. The action of MMP2 abolished binding of FGF to an immobilized recombinant FGFR1 ectodomain fusion protein and to Chinese hamster ovary cells overexpressing FGFR1 The released recombinant FGFR1 ectodomain was able to bind FGF after MMP2 cleavage, suggesting that the cleaved soluble receptor maintained its FGF binding capacity. The activity of MMP2 could not be reproduced by the 92-kDa gelatinase B (MMP9) and was inhibited by tissue inhibitor of metalloproteinase type 2. These studies demonstrate that FGFR1 may be a specific target for MMP2 on the cell surface, yielding a soluble FGF receptor that may modulate the mitogenic and angiogenic activities of FGF.

Galician women translators in the 20th century: rewriting the history of translation from a gender and national approach

This article is the English version of “Traductoras gallegas del siglo XX: Reescribiendo la historia de la traducción desde el género y la nación” by Olga Castro. It was not published on the print version of MonTI for reasons of space. The online version of MonTI does not suffer from these limitations, and this is our way of promoting plurilingualism.

Compendium physicæ ex authoribus extractum, 1714

Manuscript copy of Charles Morton’s Compendium Physicae prepared by copyist Robert Ward in 1714. The leather-bound volume includes text and drawings, and there is an index to the chapters of the book at the end of the volume. "Thomas Greaves's book Octob 1 Anno Salutis 1714" inscribed on flyleaf. Thomas Greaves may refer to the Charlestown physician and judge and member of the Harvard Class of 1703.

First ( -fourth) report of the Committee appointed by the Lords of the Treasury, in pursuance of addresses of the House of Commons of the 12th, 14th, and 20th August 1839 : Ordered (by the House of Commons) to be printed ... /

Titles of 3rd and 4th reports headed: "Railway communication."

Sefer òhasidim : le-°am Y.Y. ha-âseridim, le-segule ha-dor ha-yeòhidim ... /

Mode of access: Internet.

Sefer ha-Zohar ha-kadosh: ʻal ha-Torah/

Title within ornamental border containing comments.

Tifʾeret Tsevi : ... teḳufot u-moladot ... ḳeviʻut ha-shanah ... halakhot ... shebe-maskelet Rosh ha-shanah ... ṿe-divre ha-Rambam ... be-hilkhot ḳidush ha-ḥodesh.

Mode of access: Internet.

Otsar ha-shorashim ʻa.p. Ben-Zeʼev be-ḥamishah ḥalaḳim.

Vol. 1 has added t.p.: Hebräisch und chaldäisches Woerterbuch vel verbis, J. L. Bensew. Ozar haschoraschim in 5 Theilen.

Otsar ha-shorashim : kolel shorshe ha-lashon ha-ʻIvrit ... ṿe-haʻataḳatam...me-ʻIvrit le-ʼAshkenazit ume-ʼAshkenazit le-ʻIvrit.

Mode of access: Internet.

Otsar ha-shorashim; kolel shorshe ha-lashon ha-ʻIvrit, ʻim pitron horaʼotehem ṿe-haʻataḳatam me-ʻIvrit le-Ashkenazit ume-Ashkenazit le-ʻIvrit.

Mode of access: Internet.

Otsar ha-shorashim : kolel shorshe ha-lashon ha-ʻIvrit ṿe-haʻataḳatam...me-ʻIvrit le-Ashkenazit ume-Ashkenazit le-ʻIvrit...gam ha-shorashim bi-leshon Aramit u-shemot ha-anashim ṿeha-meḳomot ha-nimtsaʼim be-khitve ḳodesh /

Added t.p.: Hebräisch-deutsches and deutsch-hebräisches Wörterbuch über das alte Testament.

Sefer Torah, Neviʼim u-Khetuvim : meduyaḳ heṭev ʻal pi ha-Masorah /

Mode of access: Internet.

Sefer Mīney targūmaʾ : ṿe-hūʾ ḥibūr kōlel beʾūrīm ... be-divrey targūm ʾŌnqelōs ʻal ha-Tōrah.

Mode of access: Internet.

Sēfer ha-Ḳusari ...

Mode of access: Internet.