Confirmation of Daniel D. Moore to be Collector of Internal Revenue : hearings before the Committee on Finance, United States Senate, Seventy-third Congress, second session, on confirmation of Daniel D. Moore, of New Orleans, La., to be Collector of Internal Revenue, Apr.4-13, 1934.

[Pt. 1] has title: Confirmation of Daniel D. Moore to be Collector of Internal Revenue : hearing before a subcommittee of the Committee on Finance ... Feb. 19, 1934.

The historians of the church of York and its archbishops.

v. 3 published by Eyre and Spottiswoode

The early ecclesiastical history of Dewsbury in the West-Riding of the county of York : including a sketch of the introduction of christianity into Northumbria : to which are added ... Dr. Whitaker's account of Dewsbury ... /

Cover title: Early history of Dewsbury.

Beverlac; or, The antiquities and history of the town of Beverley, in the county of York, and of the provostry and collegiate establishment of St. John's; with a minute description of the present minster and the church of St. Mary, and other ancient and modern edifices.

Paged continuously.

The history of Richmond, in the county of York; including a description of the castle, friary, Easeby-abbey, and other remains of antiquity in the neighbourhood.

Published anonymously. Author's name appears in edition of 1821.

The history of Wakefield, in the county of York. The rectory manor, with biographical and other notices of some of the persons connected therewith.

Mode of access: Internet.

Domesday studies: an analysis and digest of the Somerset survey (according to the Exon codex), and of the Somerset gheld inquest of A. D. 1084, as collated with, and illustrated by, Domesday.

v.1. Analysis and digest.--v.2. Tables.

William Laud, sometime archbishop of Canterbury : a study / by Arthur Christopher Benson.

Mode of access: Internet.

Report of the Royal Commission on Divorce and Matrimonial Causes [with Minutes of evidence, and Appendices to the Minutes of evidence and Report]

"Minority report by ... the Archbishop of York, Sir William R. Anson ... and Sir Lewis T. Dibdin ... ": p. 171-191 (of the Report)

The letters of Thomas Gray, including the correspondence of Gray and Mason.

Mode of access: Internet.

Beverlac; or, The antiquities and history of the town of Beverley, in the county of York,

Mode of access: Internet.

Nomination of William D. Ruckelshaus : hearings before the Committee on Environment and Public Works, United States Senate, Ninety-eighth Congress, first session, on the nomination of William D. Ruckelshaus, to be Administrator of the Environmental Protection Agency, May 3, 4, and 5, 1983.

Includes bibliographical references.

Prospective evaluation of a D-optimal designed population pharmacokinetic study

Recently, methods for computing D-optimal designs for population pharmacokinetic studies have become available. However there are few publications that have prospectively evaluated the benefits of D-optimality in population or single-subject settings. This study compared a population optimal design with an empirical design for estimating the base pharmacokinetic model for enoxaparin in a stratified randomized setting. The population pharmacokinetic D-optimal design for enoxaparin was estimated using the PFIM function (MATLAB version 6.0.0.88). The optimal design was based on a one-compartment model with lognormal between subject variability and proportional residual variability and consisted of a single design with three sampling windows (0-30 min, 1.5-5 hr and 11 - 12 hr post-dose) for all patients. The empirical design consisted of three sample time windows per patient from a total of nine windows that collectively represented the entire dose interval. Each patient was assigned to have one blood sample taken from three different windows. Windows for blood sampling times were also provided for the optimal design. Ninety six patients were recruited into the study who were currently receiving enoxaparin therapy. Patients were randomly assigned to either the optimal or empirical sampling design, stratified for body mass index. The exact times of blood samples and doses were recorded. Analysis was undertaken using NONMEM (version 5). The empirical design supported a one compartment linear model with additive residual error, while the optimal design supported a two compartment linear model with additive residual error as did the model derived from the full data set. A posterior predictive check was performed where the models arising from the empirical and optimal designs were used to predict into the full data set. This revealed the optimal'' design derived model was superior to the empirical design model in terms of precision and was similar to the model developed from the full dataset. This study suggests optimal design techniques may be useful, even when the optimized design was based on a model that was misspecified in terms of the structural and statistical models and when the implementation of the optimal designed study deviated from the nominal design.

Formation of mononuclear and chloro-bridged binuclear copper(II) complexes of patellamide D, a naturally occurring cyclic peptide: influence of anion and solvent

Patellamide D (patH(4)) is a cyclic octapeptide isolated from the ascidian Lissoclinum patella. The peptide possesses a 24-azacrown-8 macrocyclic structure containing two oxazoline and two thiazole rings, each separated by an amino acid. The present spectrophotometric, electron paramagnetic resonance (EPR) and mass spectral studies show that patellamide D reacts with CuCl, and triethylamine in acetonitrile to form mononuclear and binuclear copper(II) complexes containing chloride. Molecular modelling and EPR studies suggest that the chloride anion bridges the copper(II) ions in the binuclear complex [Cu-2(patH(2))(mu-Cl)](+). These results contrast with a previous study employing both base and methanol, the latter substituting for chloride in the copper(II) complexes en route to the stable mu-carbonato binuclear copper(II) complex [Cu-2 (patH(2))(mu-CO3)]. Solvent clearly plays an important role in both stabilising these metal ion complexes and influencing their chemical reactivities. (C) 2004 Elsevier Inc. All rights reserved.