Frances Lander Spain Papers - Accession 4

The Frances Lander Spain Papers consists of correspondence, clippings, photographs, memorabilia, and copies of her publications relating to her involvement with professional library organizations such as the American Library Association; her library work in Thailand as a Fulbright and Rockefeller Foundation grantee (1951-1952 and 1964-1965); and her work as coordinator of children’s services at the N.Y. Public Library (1953-1961). Correspondents include librarian Louis Round Wilson. There is also a family history which includes the family names Chambers, Collier, Cook, Crossland, Dantzler, Gran, Hardeman, Lander, McDaniel, McPherson, Miller, Pearce, Pierce, Schenk, Snead, Spain, Sparks, Warlick and Zimmerman.

Lucia B. Bell Papers - Accession 255

The Lucia B. Bell Papers consist of historical and family history information pertaining to the Bell family of South Carolina. Most of the material relates to the Bell Family and other allies clans such as the Gaston, Coln, and Stinson Families. The earliest dated material includes notes on the Bell family’s coat-of-arms and a listing of land grants from 1770-1848. Information on the Chester County Covenanters along with reprinted historical sketches concerning the area’s general history and a biographical sketch on Reverend William Martin, the first Chester County Covenanter preacher. A brief history of Fishing Creek Presbyterian Church is provided with listing of former church elders and deacons from 1895-1958.

Juanita H. Neely Papers - Accession 6

The Juanita H. Neely Papers consist of correspondence, autobiographical and biographical data, speeches, radio talks, clippings, photographs, and articles mainly relating to her work with the South Carolina Home Demonstration Extension Service. There is also family history material relating to the Neely family. This collection is a good source of information concerning the South Carolina Home Economics Extension program in the first half of the twentieth century. While the papers range from 1911 to about 1970, the more valuable and greater part of the collection extends from the mid-1920s to 1957, when Juanita Neely rose from a county home economics extension agent to the State Demonstration Agent. The collection contains many of her speeches, radio talks and articles made during this period; the reference material that she used for her speeches; letters of appreciation from agents and others upon her retirement; and materials relating to the Winthrop-Clemson controversy in 1955 concerning the location of the Home Economics Extension Program. There is also biographical material, award notices, and some correspondence dating after Juanita Neely's retirement from the Home Economics Extension Program. Additional Neely information may be found by referring to the Winthrop Archives, record group 412, and the 1958-1959 edition of Who’s Who of American Women.

Jessie Huey Laurence Papers - Accession 5

The Jessie Huey Laurence Papers primarily consist of correspondence, but also included are speeches, program notes, minutes, financial records, photographs, clippings, and scrapbooks relating to her role in the South Carolina Federation of Women’s Clubs (1928-1937); her promotion of a compulsory school attendance bill for South Carolina (1934-1936); the formation of the South Carolina Council for the Common Good (1935); Works Progress Administration (WPA) and Public Works Administration (PWA) projects in South Carolina; and her interest in the Catawba Indians of York County, as chairman of Indian Affairs Committee for the Catawba Chapter of the Daughters of the American Revolution. Subjects include literacy, Santee-Cooper Dam, Winthrop College, World War II, York County Historical Society, York, Chester, and Lancaster Counties and family history material including: Adams, Craig, Jackson, Lesslie, Lessly, Mull, Muehl, Robinson, Taylor, Weidner, Witherspoon, and Wylie families.

Mary Eva Hite Papers - Accession 187

The Mary Eva Hite Papers consists of correspondence, speeches, newspaper clippings, family history data, photographs, awards, scrapbooks, and other records relating to Mary Eva Hite’s career as an educator and prominent South Carolina public servant. The photograph file provides a visual record of South Carolina elementary school life in the first half of the twentieth century. Correspondence relates to Dr. Hite’s many career activities, including her 1970 correspondence highlighting her work promoting the welfare of senior citizens. The speeches focus on her work with the aged, her travels abroad, and acceptances for awards presented to her by educational and civic organizations. Newspaper clippings provide information concerning awards presented to Dr. Hite and chronicle the advances in education made by the state of South Carolina. Scrapbooks relate to college friends and Dr. Hite’s work with Delta Kappa Gamma. There are also records relating to teacher retirement in South Carolina.

James Pinckney Kinard Papers - Accession 8

The James Pinckney Kinard Papers consist of family history charts of the Kinard family and related Kuhn and Summer families, and a Kinard family history, personal correspondence including letters to and from his wife Lee Wicker Kinard (1873-1963), their daughter Nelle Kinard, and other family members, business correspondence, financial papers, literary manuscripts, scrapbooks, and photographs pertaining to Kinard’s student days at the Citadel, his personal and family affairs, his teaching career, his presidency of Winthrop, and his efforts to get his literary manuscripts published. This collection consists primarily of correspondence and offers an informative insight into the personal lives and family affairs of Dr. Kinard and his wife, Mrs. Lee Wicker Kinard. The correspondence generally deals with Dr. Kinard’s struggle against the South Carolina legislature’s cuts in educational appropriations for Winthrop during the Depression; and his varied activities on behalf of Winthrop as President Emeritus. The collection also includes several unpublished manuscripts ranging from his student days at the Citadel to his later life. Areas of research would perhaps include, among others, biographical information on Dr. Kinard and social history during the Depression.

Ida Crawford Stewart Papers - Accession 487

The Stewart Papers consist of correspondence, newspaper articles, photographs, financial records, and other papers, relating to Stewart’s family history as well as such subjects as slavery, the American Civil War, Reconstruction in the South, and Mrs. Stewart’s professional career.

Is Everyone Rated Equal? An Examination of Factors Related to Sexual Risk in Ethnically Diverse Male Adolescents Who Have Sexually Offended

As the juvenile justice system has evolved, there has been a need for clinicians to make judgments about risk posed by adolescents who have committed sexual offenses. There are inherent difficulties in attempting to assess risk for violence among adolescents due to the developmental changes taking place and the absence of well-validated instruments to guide risk prediction judgments. With minority groups increasing in numbers in the U.S., it is likely that professionals will encounter minority individuals when conducting risk assessments. Overall questions regarding race/ethnicity have been neglected and there are few if any published research that explores risk factors with minority juvenile sex offenders. The present study examined whether differences exist between Caucasian and racial/ethnic minority adolescent sexual offenders on four risk assessment measures (J-SORRAT-II, J-SOAP-II, SAVRY, and ERASOR). The sample of 207 male adolescent sexual offenders was drawn from treatment facilities in a Midwestern state. Overall results indicated that minority adolescent sex offenders had fewer risk factors endorsed than Caucasian youth across all risk assessment tools. Exploration of interactions between race and factors such as: family status, exposure to family violence, and family history of criminality upon the assessment tools risk ratings yielded non-significant findings. Limitations, suggestions for future directions, and clinical implications are discussed.

Prevalência e fatores associados à síndrome metabólica em usuários de unidades básicas de saúde em São Paulo - SP

OBJETIVO: Determinar a relação da síndrome metabólica (SM) com o nível socioeconômico, hábitos comportamentais, condições de saúde, antecedentes familiares de morbidades e áreas de residência. MÉTODOS: Trata-se de um estudo de corte transversal. A amostra aleatória foi constituída por usuários de duas Unidades Básicas de Saúde da cidade de São Paulo - Jardim Comercial (UBS1) e Jardim Germânia (UBS2) -, totalizando 452. Para o diagnóstico de SM utilizou-se o critério do Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (NCEP-ATP III). Na avaliação antropométrica foram aferidas medidas de peso, estatura, circunferências abdominal e do quadril. Foi utilizado questionário geral para obtenção de dados sociodemográficos, socioeconómicos, antecedentes familiares e pessoais de morbidades, hábitos comportamentais como tabagismo, etilismo e nível de atividade física. Foi estabelecida associação entre as variáveis explicativas de interesse e SM, empregando-se a regressão logística multivariada. RESULTADOS: Na UBS1, o percentual de SM foi de 56,1% e na UBS2, de 34,0%. Houve associação direta e significativa entre SM e idade, sexo feminino, cor, tabagismo, etilismo, nível de atividade física, estresse e antecedentes familiares de doença cardíaca e de diabetes mellitus. A escolaridade apresentou associação inversa: morar no bairro de menor nível socioeconómico aumentou a chance de SM. CONCLUSÃO: Os resultados sugerem que as morbidades que compõem a SM são um grave problema de saúde pública nessa população.

Assessing Pathogenicity for Novel Mutation/Sequence Variants: The Value of Healthy Older Individuals

Improvement in DNA technology is increasingly revealing unexpected/unknown mutations in healthy persons and generating anxiety due to their still unknown health consequences. We report a 44-year-old healthy father of a 10-year-old daughter with bilateral coloboma and hearing loss, but without muscle weakness, in whom a whole-genome CGH revealed a deletion of exons 38-44 in the dystrophin gene. This mutation was inherited from her asymptomatic father, who was further clinically and molecularly evaluated for prognosis and genetic counseling (GC). This deletion was never identified by us in 982 Duchenne/Becker patients. To assess whether the present case represents a rare case of non-penetrance, and aiming to obtain more information for prognosis and GC, we suggested that healthy older relatives submit their DNA for analysis, to which several complied. Mutation analysis revealed that his mother, brother, and 56-year-old maternal uncle also carry the 38-44 deletion, suggesting it an unlikely cause of muscle weakness. Genome sequencing will disclose mutations and variants whose health impact are still unknown, raising important problems in interpreting results, defining prognosis, and discussing GC. We suggest that, in addition to family history, keeping the DNA of older relatives could be very informative, in particular for those interested in having their genome sequenced.

Sensory phenomena associated with repetitive behaviors in obsessive-compulsive disorder: An exploratory study of 1001 patients

A substantial number of patients with obsessive-compulsive disorder (OCD) report compulsions that are preceded not by obsessions but by subjective experiences known as sensory phenomena. This study aimed to investigate the frequency, severity, and age at onset of sensory phenomena in OCD, as well as to compare OCD patients with and without sensory phenomena in terms of clinical characteristics. We assessed 1,001 consecutive OCD patients, using instruments designed to evaluate the frequency/severity of OC symptoms, tics, anxiety, depression, level of insight and presence/severity of sensory phenomena. All together, 651 (65.0%) subjects reported at least one type of sensory phenomena preceding the repetitive behaviors. Considering the sensory phenomena subtypes, 371 (57.0%) patients had musculoskeletal sensations, 519 (79.7%) had externally triggered "just-right" perceptions, 176 (27.0%) presented internally triggered "just right," 144 (22.1%) had an "energy release," and 240 (36.9%) patients had an "urge only" phenomenon. Sensory phenomena were described as being as more severe than were obsessions by 102(15.7%) patients. Logistic regression analysis showed that the following characteristics were associated with the presence of sensory phenomena: higher frequency and greater severity of the symmetry/ordering/arranging and contamination/washing symptom dimensions; comorbid Tourette syndrome, and a family history of tic disorders. These data suggest that sensory phenomena constitute a poorly understood psychopathological aspect of OCD that merits further investigation. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

Ethnicity and Cutaneous Melanoma in the City of Sao Paulo, Brazil: A Case-Control Study

Background: Over the last century the incidence of cutaneous melanoma has increased worldwide, a trend that has also been observed in Brazil. The identified risk factors for melanoma include the pattern of sun exposure, family history, and certain phenotypic features. In addition, the incidence of melanoma might be influenced by ethnicity. Like many countries, Brazil has high immigration rates and consequently a heterogenous population. However, Brazil is unique among such countries in that the ethnic heterogeneity of its population is primarily attributable to admixture. This study aimed to evaluate the contribution of European ethnicity to the risk of cutaneous melanoma in Brazil. Methodology/Principal Findings: We carried out a hospital-based case-control study in the metropolitan area of Sao Paulo, Brazil. We evaluated 424 hospitalized patients (202 melanoma patients and 222 control patients) regarding phenotypic features, sun exposure, and number of grandparents born in Europe. Through multivariate logistic regression analysis, we found the following variables to be independently associated with melanoma: grandparents born in Europe-Spain (OR = 3.01, 95% CI: 1.03-8.77), Italy (OR = 3.47, 95% CI: 1.41-8.57), a Germanic/Slavic country (OR = 3.06, 95% CI: 1.05-8.93), or >= 2 European countries (OR = 2.82, 95% CI: 1.06-7.47); eye color-light brown (OR = 1.99, 95% CI: 1.14-3.84) and green/blue (OR = 4.62; 95% CI 2.22-9.58); pigmented lesion removal (OR = 3.78; 95% CI: 2.21-6.49); no lifetime sunscreen use (OR = 3.08; 95% CI: 1.03-9.22); and lifetime severe sunburn (OR = 1.81; 95% CI: 1.03-3.19). Conclusions: Our results indicate that European ancestry is a risk factor for cutaneous melanoma. Such risk appears to be related not only to skin type, eye color, and tanning capacity but also to others specific characteristics of European populations introduced in the New World by European immigrants.

Ischemic heart disease and correlates in adults from Ribeirao Preto, Brazil

OBJECTIVE: To identify the prevalence of ischemic heart disease (IHD) and correlates in an adult population. METHODS: Cross-sectional population-based epidemiological study including a weighted sample of 2,471 adults of both sexes and with age 30 years or older residing in Ribeirao Preto, Southeastern Brazil, in 2007. The Rose Questionnaire was administered, and IHD prevalence was calculated with point estimates and 95% confidence intervals. To identify correlates (sociodemographic, cardiovascular risk factors, and those related to access to health services and to physical activity level), crude and adjusted prevalence ratios were estimated using Poisson regression. RESULTS: IHD prevalence was higher in females than males at all age strata. In the final model, the following variables were independently associated with IHD: work status (PR = 0.54 [0.37; 0.78]); family history of IHD (PR = 1.55 [1.12;2.13]); hypertension (PR = 1.70 [1.18;2.46]); self-reported health status (PR=2.15 [1.40;3.31]); smoking duration (third tertile) (PR=1.73 [1.08;2.76]); adjusted waist circumference (PR=1.79 [1.21;2.65]) and hypertriglyceridemia (PR=1.48 [1.05;2.10]). Linear trend test of PR across self-reported health status categories was statistically significant (p<0.05). CONCLUSIONS: A high prevalence of IHD was found, and the factors associated with the outcome are almost all modifiable and potentially influenced by public policy interventions.

Li-Fraumeni-like syndrome associated with a large BRCA1 intragenic deletion

Background: Li-Fraumeni (LFS) and Li-Fraumeni-like (LFL) syndromes are associated to germline TP53 mutations, and are characterized by the development of central nervous system tumors, sarcomas, adrenocortical carcinomas, and other early-onset tumors. Due to the high frequency of breast cancer in LFS/LFL families, these syndromes clinically overlap with hereditary breast cancer (HBC). Germline point mutations in BRCA1, BRCA2, and TP53 genes are associated with high risk of breast cancer. Large rearrangements involving these genes are also implicated in the HBC phenotype. Methods: We have screened DNA copy number changes by MLPA on BRCA1, BRCA2, and TP53 genes in 23 breast cancer patients with a clinical diagnosis consistent with LFS/LFL; most of these families also met the clinical criteria for other HBC syndromes. Results: We found no DNA copy number alterations in the BRCA2 and TP53 genes, but we detected in one patient a 36.4 Kb BRCA1 microdeletion, confirmed and further mapped by array-CGH, encompassing exons 9-19. Breakpoints sequencing analysis suggests that this rearrangement was mediated by flanking Alu sequences. Conclusion: This is the first description of a germline intragenic BRCA1 deletion in a breast cancer patient with a family history consistent with both LFL and HBC syndromes. Our results show that large rearrangements in these known cancer predisposition genes occur, but are not a frequent cause of cancer susceptibility.

Protease Inhibitor and Metabolic Alteration

Protease inhibitors (PIs), part of HAART (Highly Active Antiretroviral Therap) are selective, competitive inhibitors of protease, a crucial enzyme to viral maturation, infection and replication. A lipodystrophic syndrome has been reported in individuals treated with HAART, and associated to hyperglycemia, hypercholesterolemia, hypertrigliceridemia, hyperlipidemia, hypertension and hypreinsulinemia. The HAART-associated metabolic abnormalities were first associated with protease inhibitors, Ritonavir mostly, but the mechamisns that underlie these metabolic alterations are to date, not completely understood. Since Pis are candidate to be the drug of choice for other diseases treatment, such as the Hepatitis C, malaria and some types of cancer, it seems to be important to clarify the metabolic alterations associated to PIs. Wistar rats were treated twice a week with 30mg/kg Ritonavir for 4 and 8 weeks. Total cholesterol, HDL, LDL, VLDL, triglycerides and glycemic levels were measured by the end of each period of time selected. To avoid confunding effects of food intake, the animals were fasted 16 hours before. Our results showed rapid increase in serum triglycerides, total cholesterol, LDL-C and glycemic levels. No significant differences were observed for HDL-C or VLDL serum levels. Our study addresses the importance to observe the possible family history of dyslipidemia or diabetes, and control any other cardiovascular and diabetes risk factors when using protease inhibitors