782 resultados para Engel, Antke
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von Chaijm Bloch
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von Mehemed Emin Efendi
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Josef Popper
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ursprünglich bearb. v. E. Hecht u. M. Kayserling. Nach der in Verb. mit Biach hergestellten 8. Aufl. neu bearb. 9. Aufl. von (Max) Doctor
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von Heinrich Berger
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von H. Fuchs
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von Ne'man [d.i. Siegfried Lichtenstädter]
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The surrounding capsule of Streptococcus pneumoniae has been identified as a major virulence factor and is targeted by pneumococcal conjugate vaccines (PCV). However, nonencapsulated Streptococcus pneumoniae (Non-Ec-Sp) have also been isolated globally, mainly in carriage studies. It is unknown if Non-Ec-Sp evolve sporadically, if they have high antibiotic non-susceptiblity rates and a unique, specific gene content. Here, whole genome sequencing of 131 Non-Ec-Sp isolates sourced from 17 different locations around the world was performed. Results revealed a deep-branching classic lineage that is distinct from multiple sporadic lineages. The sporadic lineages clustered with a previously sequenced, global collection of encapsulated S. pneumoniae (Ec-Sp) isolates while the classic lineage is comprised mainly of the frequently identified multi-locus sequences types ST344 (n=39) and ST448 (n=40). All ST344 and nine ST448 isolates had high non-susceptiblity rates to β-lactams and other antimicrobials. Analysis of the accessory genome reveals that the classic Non-Ec-Sp contained an increased number of mobile elements, than Ec-Sp and sporadic Non-Ec-Sp. Performing adherence assays to human epithelial cells for selected classic and sporadic Non-Ec-Sp revealed that the presence of a integrative conjugative element (ICE) results in increased adherence to human epithelial cells (P=0.005). In contrast, sporadic Non-Ec-Sp lacking the ICE had greater growth in vitro possibly resulting in improved fitness. In conclusion, Non-Ec-Sp isolates from the classic lineage have evolved separately. They have spread globally, are well adapted to nasopharyngeal carriage and are able to coexist with Ec-Sp. Due to continued use of pneumococcal conjugate vaccines, Non-Ec-Sp may become more prevalent.
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der israelitischen Jugend erzählt von Frida Bach
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nach dem Engl. der Elma Ehrlich Levinger frei bearb. von K. Treitel-Brann
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einer wahren Begebenheit nacherzählt von W. Herzberg
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von Ne'man [d.i. Siegfried Lichtenstädter]
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von Leo Herzberg-Fränkel
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von S. D. Weiskopf