Physico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermia

Sodium azumolene is a drug designed to fight Malignant Hyperthermia (MH), which is characterized by genetic predisposition and triggered by the use of inhalational anesthetics. This drug is shown as a water-soluble analogue of dantrolene sodium, 30-folds more water soluble, which gives advantages for its emergency use. To our knowledge there is no analytical method for sodium zaumolene raw material or dosage form published so far. The objective of the present investigation was to develop and validate analytical methods to achieve sodium azumolene chemical identification and quantification. The sodium azumolene was characterized regarding its thermal behavior, by differential thermal analysis and thermogravimetric analysis; Visible, UV and infrared absorption. To accurately assess the sodium Azumolene content three different analytical methods (visible and UV spectrophotometry and high performance liquid chromatography) were developed and validated. All methods showed to be linear, accurate, precise and reliable. Azumolene has shown to be equipotent to dantrolene in the treatment and prevention of an MH crisis and the great advantage compared to dantrolene is better water solubility. This study has characterized the sodium azumolene and presents new analytical methods which have not been reported so far.

Development of bovine abomasum in prenatal period

For this purpose, samples of Nelore fetus abomasum (Bos taurus indicus) were classified into five groups: 1 – fetuses with 9 to 15 weeks (8 to 21 cm) of gestation, 2 – fetuses with 16 to 22 weeks (23 to 37 cm), 3 – fetuses at 23 to 29 weeks (40 to 58 cm) 4 – fetuses with 30 to 36 weeks (61 to 77 cm) and 5 – fetuses with 37 to 43 weeks (79 to 88 cm). Histologic sections were stained with Hematoxylin and eosin, picrosirius and Mallory’s trichrome methods and examined under light microscopy. In fetus with 11 cm of length showed deep mucosa, wide folds and villi lined by single cylindrical epithelium, lamina propria, submucosa, muscular sublayers and serosa. Fetus with 13.5 cm, villi were evident and muscular layer of the mucosa was formed. At 16.5 cm, could be seen an increase in mucosa glands size and number. In fetus of 26 cm, showed gastric mucous glands at great number and ramifications. At 29 cm large folds, were observed. At 37 cm, showed glandular epithelium, muscular layer of the mucosa and muscular layer well development. Fetus with 42 cm, showed deep glands with corresponding mucous cells surrounding by thin lamina propria. It was concluded that the histomorphometric values of muscular layer and total abomasum wall were increased for all groups except for groups 4 and 5 which there was a decline of values, without presenting a significant difference and there was no continuous pattern of growth for other components of abomasum wall.

Alterações antropométricas de lesados medulares após treinamento intervalado em natação

The goal of this study was to assess the alterations in some anthropometric measures of sedentary subjects with spinal cord injury after a swimming interval training program with the use of a lifejacket. The study included 17 male spinal cord injured subjects, divided into two groups: 11 subjects in the training group (TG) and 6 in the control group (CG).The protocol employed a stroke of breaststroke, in work periods of moderate to severe, and stroke in the back stroke in periods of active recovery. An anthropometric evaluation was applied before the application of the training protocol and another (reevaluation) after 8 weeks. In the TG, the results obtained after the swimming program showed a significant change (p < 0.05) in the supra-iliac (SICF) and in the triciptal cutaneous folds (TCF), arm and waist circumference measures, from the first evaluation to the reevaluation. In the CG there were no significant changes observed in any of the variables studied. When comparing the two groups after the swimming training program, the average of the variable SICFT in the TG was significantly lower than the average for the CG. Generally speaking, the out comings showed the swimming protocol efficiency in promoting desirable anthropometric changes in spinal cord injured subjects while a reduction of fatty tissue in the arms and abdominal region and an increase of muscular tissue in the upper limbs of those subjects also occurred.

Parâmetros construtivos de kirigami tridimensional de 90 graus de abertura

Origami folds and kirigami cuts merged in an oriental technique called Origamic Architecture (or 3D kirigami) that has intrinsic relationships with geometry as well as these paper arts. Despite its potential, it is not very used as a didactic resource because of the lack of parameters in its construction. There are many studies about programs development and computational language to help the design of pop-up structures, as origamic architecture is also known. However, there are few studies concerning the study of positioning the lines and creases, which is essential in the process of creating a 3D kirigami design, especially in the development of spatial perception of the figure. Limited to the 90o open type models, this article is about the establishment of some initial guidelines for design of an origamic architecture through visual elements as point, line and shape. It is presented some basic models to illustrate the constructive parameters detected as well as some models elaborated by the author, showing the viability of the guidelines established.

Origami e kirigami: arte e cultura como recurso lúdico e educativo

We can know a people through their cultural and artistic assets. One of the many aspects of Japanese culture is origami, a fusion of the verb “oru”, which means folding, with the word “kami” meaning paper. In this communication, we describe the course “Origami and Kirigami: art and culture as a recreational and educational resource”. The course aimed to present these two oriental techniques based on paper and its potential as a source of entertainment and education, at the same time seeking to introduce cultural aspects of these arts of folding and/or cutting paper. This practice is more common than we realize, and is present in our day-to-day life when we perform actions such as folding clothes and papers, and making packages, amongst others. However, few are aware of the benefits that this folding brings to the fields of Arts, Mathematics, and Science, besides its recreational characteristics. Kirigami is a mixed technique that in addition to using folds in the paper (as in origami) also uses cuts (“kiru” – meaning, “cut”). It can be performed with heavier paper than origami, and by introducing some cuts, the paper can be folded to form the desired shape. It is a simple technique, with impressive results. We conducted eight weekly meetings, each lasting four hours, totaling 32 hours of coursework. In addition to the classes, a visit was made to the Okinawa Club in Bauru (São Paulo), where it was possible for the students of the course and the elderly group (fujinkai) of origamists of the club to exchange experiences. Finally, an exhibition was organized to display the artifacts produced by the course participants and disseminate the work of the students.

Estudo de microscopia eletronica de varredura e transmissão de pregas vocais de idosos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Caracterização geofísica e geológica das formações ferríferas do Grupo Macaúbas - MG

Pós-graduação em Geologia Regional - IGCE

Aptidão física associada às medidas antropométricas de escolares do ensino fundamental

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Gibberellic acid, ozone and 1-methylcyclopropene on the gray mold control in avant garde rose

Gray mold caused by Botrytis cinerea is considered the major disease of greenhouse grown flowers. The goal of this study was to evaluate the effects of gibberellic acid (GA3), ozone, and 1-MCP, applied on postharvest, on the gray mold control in 'Avant Garde' rose. Rose flowers were artificially inoculated with B. cinerea (104 conidia ml-1) and non-inoculated. After treatments, roses were stored under room conditions (20±2°C/80±5% RH) and checked for gray mold incidence and severity. Spraying of GA3 at 25, 50, and 75 mg L-1 on non-inoculated roses reduced the area under the disease progress curve (AUDPC) of gray mold incidence in 41, 40 and 54%, respectively. Continuous application of ozone at 2.7 ppm reduced 14-folds B. cinerea sporulation. On the other hand, 1-MCP did not control gray mould in rose. These results showed that GA3 sprays and ozone contribute to postharvest control of gray mold in cut rose and can be utilized on integrated disease management.

Efeitos do uso de Decanoato de Nandrolona sobre a junção neuromuscular de ratos em processo de envelhecimento submetidos ao exercício resistido

Pós-graduação em Bases Gerais da Cirurgia - FMB

Estudos experimentais e teórico-computacionais de novos complexos nanozeólitas-enzimas empregados na produção de biocombustíveis

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

A voz do idoso: características clínicas, endoscópicas, vocais e morfológicas

Pós-graduação em Bases Gerais da Cirurgia - FMB

Cathetocephalus thatcheri gen. et sp. n. (Tetraphyllidea: Cathetocephalidae) fam. n. from the Bull Shark

Cathetocephalus thatcheri gen. et sp. n. is described from the spiral valve of the bull shark, Carcharhinus leucas (Valenciennes), taken in the Gulf of Mexico and the Atlantic coast of Florida. A new family is erected for the new genus. The species most closely resembles Pillersium owenium Southwell, 1927, in that both possess a scolex which is perpendicular to the long axis of the strobila. It differs, however, in having a single neck and holdfast organ rather than a bifurcate neck with two bothridia. Also, the surfaces of the scolex differ from those of P. owenium by possessing fleshy papilliform structures on the leading and trailing edges rather than leaflike folds. Specimens with several strobilae are figured and discussed.

A voz do idoso: características clínicas, endoscópicas, vocais e morfológicas

Pós-graduação em Bases Gerais da Cirurgia - FMB

COMPARATIVE ANATOMICAL STUDY OF TWO SPECIES OF SEMELE FROM THAILAND (BIVALVIA: TELLINOIDEA)

An anatomical description of two semelids from Thailand is presented, based on samples from Kungkrabaen Bay, Gulf of Thailand. The species are Semele sinensis A. Adams, 1853, and S. carnicolor (Hanley, 1845), both with Indo-Pacific distributions. Morphology in these two species is typically tellinoidean, each with a long internal ligamental element (resilium), a distance between the inner fold of the mantle edge and the other two folds, long and branched gastric ducts to the digestive diverticula, and a stomach diverticulum located in the posterodorsal corner of the gastric chamber, projecting posteriorly. The main anatomical differentiation between the two species is in the character of the labial palps.