G.H. Mead

G.H. Mead (1863-1931) oriented much of his intellectual efforts around three unavoidable questions for anyone living in a modern society: how are selfhood, knowledge, and politics understood and organized in such a society? Modern individuals continually seek answers to questions although nobody has ever come up with a definitive answer to them. Modernity, in other words, confronts us with inevitable problematics that fundamentally shape the way in which we think about certain topics. For the purposes of my discussion of Mead, I focus upon three of these modern problematics: science, selfhood, and democratic politics. But before I discuss Mead’s treatment of these problem areas, allow me to briefly situate Mead as a pragmatist in relation to Dewey and James within pragmatism.

Literatura, constructos cosmovisionarios y conflictos sociales : "la shoá" y "la violencia" Laura Restrepo y George steiner: aproximaciones desde la pragmática de la productividad realista intencional

Trabalho de Projecto de Mestrado em: As Humanidades na Europa: Convergências e Perspectivas. CROSSWAYS IN EUROPEAN HUMANITIES

Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection.

Polymorphisms in IL28B were shown to affect clearance of hepatitis C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We performed a 2-stage GWA study of liver fibrosis progression related to HCV infection. We studied well-characterized HCV-infected patients of European descent who underwent liver biopsies before treatment. We defined various liver fibrosis phenotypes on the basis of METAVIR scores, with and without taking the duration of HCV infection into account. Our GWA analyses were conducted on a filtered primary cohort of 1161 patients using 780,650 single nucleotide polymorphisms (SNPs). We genotyped 96 SNPs with P values <5 × 10(-5) from an independent replication cohort of 962 patients. We then assessed the most interesting replicated SNPs using DNA samples collected from 219 patients who participated in separate GWA studies of HCV clearance. In the combined cohort of 2342 HCV-infected patients, the SNPs rs16851720 (in the total sample) and rs4374383 (in patients who received blood transfusions) were associated with fibrosis progression (P(combined) = 8.9 × 10(-9) and 1.1 × 10(-9), respectively). The SNP rs16851720 is located within RNF7, which encodes an antioxidant that protects against apoptosis. The SNP rs4374383, together with another replicated SNP, rs9380516 (P(combined) = 5.4 × 10(-7)), were linked to the functionally related genes MERTK and TULP1, which encode factors involved in phagocytosis of apoptotic cells by macrophages. Our GWA study identified several susceptibility loci for HCV-induced liver fibrosis; these were linked to genes that regulate apoptosis. Apoptotic control might therefore be involved in liver fibrosis.

Grève de cheminots anglais, M. [le ministre du Travail George Henry] Roberts et sir David Shackleton [secrétaire permanent du ministère du Travail] quittant Downing Street : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56199

Dodd [George], Winslow [Charles] [joueurs de tennis participant au championnat du monde à Saint-Cloud] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59419

Dodd [George], Winslow [Charles] [joueurs de tennis participant au championnat du monde à Saint-Cloud] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59424

M. Lloyd George à la conférence [interalliée] de Boulogne-sur-Mer [21 juin 1920, revue des troupes] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59796

Le général [George Francis] Milne, commandant des forces anglaises dans la Mer Noire, joue au tennis à Constantinople : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59803

Le général [George Francis] Milne [commandant des forces anglaises dans la Mer Noire, joue au tennis à Constantinople] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59804

[Charles George] Dandrow [lanceur de poids] (C.N. New York) : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59328