Iowa School Safety Guide, April 6, 2012

This document was developed for the schools of Iowa to use as a template to enhance current school safety programs; the creation of this document was a partnered effort at the state level between the aforementioned agencies. The purpose of this document is to give school districts and individual schools a planning resource to use when creating their school safety plans. Ultimately, schools can decide how much of this document they would like to incorporate into their current plan. The original document was created by the Minnesota Department of Homeland Security, and its use was granted to Iowa Homeland Security in 2011. Iowa pulled together a panel of experts to make this document specific to Iowa’s schools, and laws. It’s important to note the partnership created by this document is intended to continue through information sharing in relation to critical assets, infrastructure protection, and school safety. Iowa Homeland Security is a representative in the Iowa Department of Public Safety, Division of Intelligence Fusion Center. This partnership allows for streamlined information sharing to the critical infrastructure owner/operators across the state. The current plan for information sharing is through the Iowa Homeland Security and Emergency Management, Threat information and Infrastructure Protection Program (TIIPP) to the Iowa Department of Education for processing and dissemination statewide. Depending on the type of information being released it could be specific to a school, district or the education sector statewide.

Audit report on the Iowa Department of Public Safety for the year ended June 30, 2013

Audit report on the Iowa Department of Public Safety for the year ended June 30, 2013

A pilot study on ocular safety and efficacy of infliximab as an antifibrotic agent after experimental filtration surgery

Purpose To evaluate the safety and efficacy of infliximab as an antifibrotic agent after experimental glaucoma filtration surgery in rabbits. Methods In a randomized, prospective, masked-observer study, 30 New Zealand Albino rabbits underwent glaucoma filtration surgery. The animals were allocated to receive either intraoperative application of infliximab (group A) or mitomycin C (MMC) at a concentration of 0.2mg/ml (group B) or balanced salt solution (BSS, control)(group C). Different infliximab doses, namely 1.0mg, 2.0mg, 3.0mg, 4.0mg, 5.0mg in 0.1ml were applied. Bleb survival and characteristics were evaluated over a 30day period. The animals were killed on postoperative day 15 and 30. Histology of the operated eyes was performed to evaluate and grade the amount of scarring in each group.Cellular density was evaluated in each case. Results Infliximab did not appear to improve the outcome of filtration surgery in this model of glaucoma filtration surgery.There was a significant decrease in cellular density in the MMC group compared to the control group (p=0.0352). There was neither a significant decrease in cellular density between the infliximab group and the control group nor between the infliximab group and the MMC group. Overall there was no difference in terms of fibrosis between the three different groups. There was slightly less inflammation in the infliximab group, but not significant. Conclusions In this study intraoperative application of infliximab does not appear to be superior to the application of MMC or a control with regard to bleb survival and fibrosis. This study however demonstrates that intraoperative application of MMC significantly reduces the cellular density of the filtration bleb.

Iowa's Center for Agriculture Safety and Health Annual Report, 2002

I-CASH is to enhance the health and safety of Iowa's agricultural community by establishing and coordinating prevention and education programs. This annual report gives information about a variety of areas that participate in I-CASH

Iowa's Center for Agriculture Safety and Health Annual Report, 2003

I-CASH is to enhance the health and safety of Iowa's agricultural community by establishing and coordinating prevention and education programs. This annual report gives information about a variety of areas that participate in I-CASH

Iowa's Center for Agriculture Safety and Health Annual Report, 2005

I-CASH is to enhance the health and safety of Iowa's agricultural community by establishing and coordinating prevention and education programs. This annual report gives information about a variety of areas that participate in I-CASH

Iowa's Center for Agriculture Safety and Health Annual Report, 2006

I-CASH is to enhance the health and safety of Iowa's agricultural community by establishing and coordinating prevention and education programs. This annual report gives information about a variety of areas that participate in I-CASH

Iowa's Center for Agriculture Safety and Health Annual Report, 2007

I-CASH is to enhance the health and safety of Iowa's agricultural community by establishing and coordinating prevention and education programs. This annual report gives information about a variety of areas that participate in I-CASH

Iowa's Center for Agriculture Safety and Health Annual Report, 2009

I-CASH is to enhance the health and safety of Iowa's agricultural community by establishing and coordinating prevention and education programs. This annual report gives information about a variety of areas that participate in I-CASH

Iowa's Center for Agriculture Safety and Health Annual Report, 2010

I-CASH is to enhance the health and safety of Iowa's agricultural community by establishing and coordinating prevention and education programs. This annual report gives information about a variety of areas that participate in I-CASH

Iowa's Center for Agriculture Safety and Health Annual Report, 2011

I-CASH is to enhance the health and safety of Iowa's agricultural community by establishing and coordinating prevention and education programs. This annual report gives information about a variety of areas that participate in I-CASH

Iowa's Center for Agriculture Safety and Health Annual Report, 2012

I-CASH is to enhance the health and safety of Iowa's agricultural community by establishing and coordinating prevention and education programs. This annual report gives information about a variety of areas that participate in I-CASH

Iowa's Center for Agriculture Safety and Health Annual Report, 2013

I-CASH is to enhance the health and safety of Iowa's agricultural community by establishing and coordinating prevention and education programs. This annual report gives information about a variety of areas that participate in I-CASH

Automatic filtering and substantiation of drug safety signals

Drug safety issues pose serious health threats to the population and constitute a major cause of mortality worldwide. Due to the prominent implications to both public health and the pharmaceutical industry, it is of great importance to unravel the molecular mechanisms by which an adverse drug reaction can be potentially elicited. These mechanisms can be investigated by placing the pharmaco-epidemiologically detected adverse drug reaction in an information-rich context and by exploiting all currently available biomedical knowledge to substantiate it. We present a computational framework for the biological annotation of potential adverse drug reactions. First, the proposed framework investigates previous evidences on the drug-event association in the context of biomedical literature (signal filtering). Then, it seeks to provide a biological explanation (signal substantiation) by exploring mechanistic connections that might explain why a drug produces a specific adverse reaction. The mechanistic connections include the activity of the drug, related compounds and drug metabolites on protein targets, the association of protein targets to clinical events, and the annotation of proteins (both protein targets and proteins associated with clinical events) to biological pathways. Hence, the workflows for signal filtering and substantiation integrate modules for literature and database mining, in silico drug-target profiling, and analyses based on gene-disease networks and biological pathways. Application examples of these workflows carried out on selected cases of drug safety signals are discussed. The methodology and workflows presented offer a novel approach to explore the molecular mechanisms underlying adverse drug reactions