Scaffold nanoestruturado utilizando-se celulose bacteriana/fosfatos de cálcio para regeneração óssea

Pós-graduação em Biotecnologia - IQ

Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos

Abstract Background: Several mechanisms have been proposed to contribute to cardiac dysfunction in obesity models, such as alterations in calcium (Ca2+) handling proteins and β-adrenergic receptors. Nevertheless, the role of these factors in the development of myocardial dysfunction induced by obesity is still not clear. Objective: The purpose of this study was to investigate whether obesity induced by hypercaloric diets results in cardiac dysfunction. Furthermore, it was evaluated whether this functional abnormality in obese rats is related to abnormal Ca2+ handling and the β-adrenoceptor system. Methods: Male 30-day-old Wistar rats were fed with standard food (C) and a cycle of five hypercaloric diets (Ob) for 15 weeks. Obesity was defined as increases in body fat percentage in rats. Cardiac function was evaluated by isolated analysis of the left ventricle papillary muscle under basal conditions and after inotropic and lusitropic maneuvers. Results: Compared with the control group, the obese rats had increased body fat and glucose intolerance. The muscles of obese rats developed similar baseline data, but the myocardial responsiveness to post-rest contraction stimulus and increased extracellular Ca2+ were compromised. There were no changes in cardiac function between groups after β-adrenergic stimulation. Conclusion: Obesity promotes cardiac dysfunction related to changes in intracellular Ca2+ handling. This functional damage is probably caused by reduced cardiac sarcoplasmic reticulum Ca2+ ATPase (SERCA2) activation via Ca2+ calmodulin kinase. (Arq Bras Cardiol 2011; 97(3) : 232-240).

Ácido fumárico e quelato de cálcio e fósforo na ração de leitões desmamados

Two experiments (E) were carried out with the objective of evaluating the effects of fumaric acid and carbo-amino-fosfo-quelato of calcium diets of weaned pigs on performance (E1) and intestinal morphology (E2). A total of 96 and 32 pigs with initial mean weights of 5,66 kg ± 0,44kg and 5,34 ± 0,45kg , in E1 and in E2, were used respectively. Randomized block designs were used in both experiments, with a 2 X 2 factorial arrangement in E1 and a 2 X 2 X 2 factorial arrangement in E2. No interaction between acidifier, source of calcium and phosphorus were found for the variables studied in the two experiments. No treatment effects were found on daily feed intake in evaluating periods. Feed conversion from 0 to 17 days was better (P<0.05) when inorganic sources of Ca and P were fed; however, no difference was observed in other periods. The averages of villus height (AV), crypt depth (PC), AV: PC relationship and mucous membrane of the duodenum and of the jejunum didn’t differ among treatments. Considering the total nursery period, no benefit was found in using an acidifier, however the carbo-amino-fosfo-quelato of calcium studied may replace the inorganic sources in the diets of piglets, with no damage to performance and to intestinal morphology.

Avaliação do hidróxido de cálcio associado à própole com agitação ultrassônica como curativo intracanal em reimplante dentário tardio

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Consumo de hidroxiprolina e amido e supersaturação urinária para oxalato de cálcio em gatos

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Nanopartículas de prata e glicerofosfato de cálcio: sínteses por rotas convencionais e fitoquímica, análise antimicrobiana e avaliação da citotoxicidade

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Propriedades físicas, químicas, antimicrobianas e biológicas de cimentos endodônticos com óxido de cálcio e resina salicilato

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo do pH e atividade antimicrobiana sobre Enterococcus faecalis de medicação intracanal à base de hidróxido de cálcio associada ao óleo de melaleuca, clorexidina ou farnesol

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeito da adição de flúor e cálcio no gel clareador a base de peróxido de hidrogênio na penetração, cor e microdureza

The objective of this study was to evaluate the effect of adding calcium ions and fluoride in the formulation of a whitening gel 35% hydrogen peroxide in its penetration through the dental structure, whitening efficacy and surface hardness of dental enamel. 80 teeth bovine incisors were used, which were obtained enamel and dentin disks of the buccal surface with 6mm diameter and 2mm thick (1 mm of enamel and dentin 1mm). The samples were divided into four groups stratified according to the protective substance / remineralizing added to the gel of hydrogen peroxide 35%: Group Ca - Calcium gluconate 0.5%; Group F - Sodium fluoride 0.2%; Group Ca + F - Calcium gluconate 0.5% and Sodium Fluoride 0.2%; Control group - no substance was added. The initial color of the samples and the hardness of the enamel were measured before the bleaching procedures. The specimens from each group were placed on a metallic support on which there was a simulated pulp chamber, which was filled with acetate buffer to collect and stabilize the penetrated peroxide. The respective bleaching treatments were applied 3 times, total of 30 minutes of application. The amount of peroxide which passed through the samples was determined by absorbance spectrophotometry. The hardness of the samples was measured immediately after bleaching. Next, the samples were immersed in artificial saliva for 7 days, after which the final color was evaluated. Data were statistically analyzed adopting a 5% significance level

Estudo do pH e atividade antimicrobiana sobre Enterococcus faecalis de medicação intracanal à base de hidróxido de cálcio associada ao óleo de melaleuca, clorexidina ou farnesol

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeito da adição de flúor e cálcio no gel clareador a base de peróxido de hidrogênio na penetração, cor e microdureza

The objective of this study was to evaluate the effect of adding calcium ions and fluoride in the formulation of a whitening gel 35% hydrogen peroxide in its penetration through the dental structure, whitening efficacy and surface hardness of dental enamel. 80 teeth bovine incisors were used, which were obtained enamel and dentin disks of the buccal surface with 6mm diameter and 2mm thick (1 mm of enamel and dentin 1mm). The samples were divided into four groups stratified according to the protective substance / remineralizing added to the gel of hydrogen peroxide 35%: Group Ca - Calcium gluconate 0.5%; Group F - Sodium fluoride 0.2%; Group Ca + F - Calcium gluconate 0.5% and Sodium Fluoride 0.2%; Control group - no substance was added. The initial color of the samples and the hardness of the enamel were measured before the bleaching procedures. The specimens from each group were placed on a metallic support on which there was a simulated pulp chamber, which was filled with acetate buffer to collect and stabilize the penetrated peroxide. The respective bleaching treatments were applied 3 times, total of 30 minutes of application. The amount of peroxide which passed through the samples was determined by absorbance spectrophotometry. The hardness of the samples was measured immediately after bleaching. Next, the samples were immersed in artificial saliva for 7 days, after which the final color was evaluated. Data were statistically analyzed adopting a 5% significance level

Avaliação clínica e radiográfica do extravasamento da pasta de hidróxido de cálcio em dentes com lesões periapicais

It has been evaluated clinically and radiographically the effect of the extrusion of calcium hydroxide paste in teeth with periapical lesions. Twenty-five patients with teeth showing pulp necrosis and periapical lesions were submitted to endodontic treatment. Dressing calcium hydroxide paste, iodoform and propylene glycol were used. Clinically, the symptoms were evaluated after treatment and, radiographically, the reabsorption of extravasated paste and repair process of the periapical lesion. Only three patients had symptoms severe in the first 24 hours, the paste was completely reabsorbed within 15 days and no interference in the repair process.

Escore de cálcio e angiotomografia coronariana na estratificação do risco cardiovascular

A doença cardiovascular representa a principal causa de mortalidade no mundo. A capacidade de identificar, dentre os indivíduos assintomáticos, o subgrupo que apresenta maior risco de desenvolver eventos cardiovasculares no futuro representa uma etapa fundamental em qualquer estratégia voltada para a diminuição da taxas de eventos cardiovasculares. O primeiro passo na estratificação do risco cardiovascular é a utilização dos "escores de risco global", dentre os quais o mais frequentemente utilizado é o escore de Framingham. Entretanto, estudos prévios demonstraram que embora muito úteis, os escores clínicos, quando utilizados isoladamente, apresentam capacidade limitada de estratificação do risco cardiovascular em uma parcela significativa da população. É nesse contexto que o escore de cálcio (EC) coronariano e a angiotomografia das artérias coronárias podem desempenhar papel importante como ferramentas complementares na estratificação de risco dos pacientes assintomáticos. O EC coronariano proporciona importantes informações prognósticas que são incrementais aos escores clínicos baseados nos fatores de risco tradicionais e a outras modalidades diagnósticas, como a dosagem da proteína C reativa, por exemplo. Além disso, o EC também tem o potencial de alterar a conduta e auxiliar no manejo clínico dos pacientes. Já a angiotomografia coronariana proporciona avaliação detalhada da anatomia das artérias coronárias, permitindo visualizar não apenas o lúmen, mas também as paredes arteriais coronarianas. Comparada à coronariografia invasiva convencional, a angiotomografia apresenta excelente acurácia para identificar e, principalmente, excluir a presença de lesões obstrutivas significativas. Adicionalmente, demonstrou-se capaz de proporcionar informações prognósticas incrementais aos fatores de risco tradicionais e ao EC coronariano.

Frutanos do tipo inulina e aumento da absorção de cálcio: uma revisão sistemática

Realizou-se uma revisão sistemática da literatura sobre os efeitos do consumo de frutanos do tipo inulina na absorção de cálcio. Resultados de quatro dos sete ensaios clínicos duplo-cegos controlados aleatorizados relatados neste trabalho indicam que o consumo diário da mistura de frutanos (inulina e oligofrutose 1:1) aumenta a absorção de cálcio, dependendo da idade cronológica e fisiológica, bem como do estado menopausal de indivíduos saudáveis que consomem quantidades adequadas de cálcio. O número limitado de ensaios clínicos realizados e as diferenças relativas ao planejamento experimental, tempo de estudo, tipo e quantidade de frutano consumido (inulina, oligofrutose ou a mistura de ambos), bem como a faixa etária dos indivíduos, impedem a generalização dos resultados observados. Esta revisão demonstra a necessidade de mais ensaios clínicos de longa duração, nos quais tanto a absorção de cálcio como a densidade mineral óssea sejam avaliadas. Futuros estudos devem contribuir para a compreensão dos mecanismos de ação dos frutanos no aumento da absorção de cálcio; para avaliar se esse efeito persiste em longo prazo e se pode ser considerado como benefício real para a saúde óssea; e para testar se tais efeitos poderiam beneficiar indivíduos de outras faixas etárias e diferentes condições fisiológicas. Evidências científicas consistentes e acumuladas ainda são necessárias para poder considerar o consumo de frutanos como uma estratégia de prevenção da osteoporose.